Báo cáo y học: "Correction: mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis" pps

... (SSc) fibroblasts and in bleomycin-exposed mice. Compared to WT mice, mPGES-1- null mice were resistant to bleomycin-induced inflammation, cutaneous thickening, collagen production and myofibroblast formation. Conclusions: ... role of mPGES-1 in the early phases of SSc by subjec ting mice deficient in mPGES-1 to the bleomycin model of skin scleroderma [21]. Materials...

Ngày tải lên: 12/08/2014, 15:22

... TSP-1 -/- mice. They only received antibiotics while they were housed prior to hypoxia. Nei- ther WT nor TSP-1 -/- mice group received antibiotics while they were exposed to hypoxia. A total of ... antibiotics we were not able to con- firm any pulmonary vascular remodeling compared to the pulmonary vascular smooth muscle cell hyperplasia reported in TSP-1 -/- mice previously by C...

Ngày tải lên: 10/08/2014, 09:22

... stacie_ngo@yahoo.com; Penny Moore - pennym@nicd.ac.za; Michael Bobardt - mbobardt@scripps.edu; Udayan Chatterji - udayan@scripps.edu; Philippe Gallay - gallay@scripps.edu; Dennis R Burton - burton@scripps.edu; ... Immunology, The Scripps Research Institute, 10666 North Torrey Pines Rd. La Jolla, CA 92037, USA, 5 Department of Immunology and Molecular Biology, The Scripps Research Institut...

Ngày tải lên: 13/08/2014, 09:20

Ngày tải lên: 14/08/2014, 21:20

... (Figure 1b). Figure 2 Histopathology (haematoxylin and eosin) in Chlamydia trachomatis-induced arthritis (CtIA) alone and after a prior exposure to mercuric chloride (HgCl 2 )Histopathology (haematoxylin and ... displays a dichotomy of resistance to infection-triggered arthritis but susceptibility to mercury-induced immune disrup- tion, we addressed how these factors would interact if t...

Ngày tải lên: 09/08/2014, 01:22

... ChIP and cytological observations Previously, based on cytological observations in human cells, it had been hypothesized that large c hromosomes tend to locate close to the nuclear periphery [42]. Although ... DNA stained by DAPI is shown in blue. The top row is wild-type N2 embryos; the bottom row is the lem-2 null mutant embryos. The arrowhead indicates the nucleus shown more closely...

Ngày tải lên: 09/08/2014, 22:23

... duplicate. Flow cytometry analysis of annexin V binding Annexin V binding analysis was used to identify dead and dying A549 cells through both apoptosis and necro- sis. A549 cells were trypsinysed (Trypsin ... study was the restricted use of A549 cells in the in vitro experiments. A549 cells are widely used in respir ator y research [13,21-23] and are a good model to study resistanc...

Ngày tải lên: 12/08/2014, 13:22

... smooth muscle, myofibroblasts in FF DakoCytomation CC10 urine protein 1 (rabbit polyclonal) Clara cells DakoCytomation cytokeratin 8/18 clone 5D3 epithelial cells Biogenex cytokeratin 5 clone ... Pathology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy, 2 Department of Pathology San Raffaele Hospital, Via Olgettina60, 20132 Milan, Italy, 3 Department of Cytomorphology, Univ...

Ngày tải lên: 12/08/2014, 16:20

... shift to constitutive secretion has been reported to occur by the experimental induction of dysfunctional prohormone convertase enzymes or by injury to the plasma membrane [29]. Perhaps some cytokines ... peptides are released into the central circulation and may act systemi- cally, as opposed to many of the known mediators of sepsis, which are released locally and often act in an...

Ngày tải lên: 12/08/2014, 18:20

... HIV-1. Conclusions: The capacity of thymic pDC to efficiently transfer R5 HIV-1 to both mature and immature thymocytes that are otherwise refractory to R5 virus may represent a pathway to early infection and ... that thy- micpDCarehighlypermissivetoHIV-1infectionand efficiently transfer R5 HIV-1 to mature and immature thymocytes. Understanding transfer of HIV-1 from thy- mic DC t...

Ngày tải lên: 13/08/2014, 01:20