Báo cáo y học: "Macrophage migration inhibitory factor enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocytes in patients with rheumatoid arthriti" doc

... 13:R43 http://arthritis-research.com/content/13/2/R43 Page 7 of 13 RESEARC H ARTIC L E Open Access Macrophage migration inhibitory factor enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocytes in patients ... immunohis- tochemical staining to compare the expression of MIF and RANKL in synovial tissues. Mor...

Ngày tải lên: 12/08/2014, 15:22

... expression by synovial lining cells in zymosan-induced arthritis (ZIA) joints of MIF -/- miceDecreased MMP-2 expression by synovial lining cells in zymosan-induced arthritis (ZIA) joints of MIF -/- ... are upstream of PKCδ. The inhibitory activity of rottlerin results from the interaction with the ATP-binding site of PKCδ, which explains why it did not inhibit the phos...

Ngày tải lên: 09/08/2014, 08:22

... mediators may induce release of MIF by Th2 cells [5]. Most importantly, MIF counter-regulates the inhibitory effects of glucocorticoids on proinflammatory cytokines, thereby enhancing the cytokine-mediated ... related to B-lymphocyte function and immunoglobulin isotype. Integration of macrophage migration inhibitory factor and the adaptive immune system The pathways described i...

Ngày tải lên: 12/08/2014, 23:23

... significantly increased in CSF of patients with purulent meningitis of known aetiology or with encephalitis, and they were to some degree associated with severity of the infection. Our findings indicate ... significantly with meningeal inflammation (P < 0.05) but not with systemic inflammatory response (P > 0.05) in patients with purulent meningitis of known...

Ngày tải lên: 13/08/2014, 16:21

... and, in part, by the host’s own inflammatory response. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine and a neuro-endocrine mediator that might play a role in pneumococcal ... patients with clinically suspected meningitis at time of admission. Elevated MIF levels were observed in patients with purulent meningitis with known bacterial aetiol...

Ngày tải lên: 13/08/2014, 18:22

... blue staining from heama- toxylin instead of brown staining. The average number of chondrocytes per sections was calculated for every joint. Image analysis: proteoglycan content PG content of articular ... signaling molecules in cartilageStaining of various transforming growth factor (TGF)-beta signaling molecules in cartilage. Paraffin sections of knee joints of young an...

Ngày tải lên: 09/08/2014, 07:20

... universality of TLR3 induction in the human system. All chosen factors, including proinflammatory cytokines and ligands of TLRs, which had been reported to be involved in RA successfully induced the upregulation ... HJ, Kim HR, Kang CM, Heo YM, Lee SH, Kim HY: TLR-3 enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocy...

Ngày tải lên: 12/08/2014, 17:22

... original data of some of the larger observational studies may allow a better judgement of consistency of the findings. The role of smoking habits Confounding by smoking is a major concern in the ... than in subjects with a low intake (less than once per week). A 100 mg increase in vitamin C intake per day is also associated with an approximately 10–50 ml increase in FEV...

Ngày tải lên: 12/08/2014, 18:20

... 4 Effect of dehydroxymethylepoxyquinomicin on serum factors involved in osteoclastogenesisEffect of dehydroxymethylepoxyquinomicin on serum factors involved in osteoclastogenesis. Effect of dehydroxymethylepoxyquinomicin ... estimation of the suppressive effect of dehydroxymethyle-poxyquinomicin on in vivo osteoclastogenesisQuantitative estimation of the suppressive effect...

Ngày tải lên: 09/08/2014, 10:21

... [45] Unclear Unclear Yes Yes Yes Yes Unclear Cheng 2007 [46] Yes Yes Yes Yes Yes Yes Low Stephens 2008 [47] Yes Yes Yes Yes Yes Yes Low Meisel 2009 [48] Yes Yes Yes Yes Yes Yes Low Bo et al. Critical ... Unclear Presneill 2002 [41] Yes Yes Yes Yes Yes Yes Low Root 2003 [42] Yes Unclear Yes Unclear Yes Yes Unclear Hartma 2005 [43] Yes Yes Yes Yes Yes Yes Low Rosen 2005 [44] Unclear Yes No Yes...

Ngày tải lên: 14/08/2014, 07:21