Báo cáo y học: " Novel autoantibodies and clinical phenotypes in adult and juvenile myositis" pptx

... found in only one patient (from 187) without necrosis and in no healthy controls, indicating that this novel autoantibody is associated with immune-mediated necrotizing myopathy. Interestingly, ... Theronyl - Alanyl - Isoleucyl - Glycyl - Asparaginyl - Tyrosyl - Phenylalanyl Anti-synthetase syndrome Myositis Interstitial lung disease Raynaud phenomenon Arthritis Mechanic’s hands F...

Ngày tải lên: 12/08/2014, 15:22

... following cytokines were measured: IL-1α, IL-1β, IL-5, IL-10, IL-12, IL-18, tumor necrosis factor-α (TNF-α), and IFN-γ. Cytokine analysis by lymphocyte intracellular staining and flow cytometry T-cell ... primarily recognized in polyarticular JIA patients. Finally, the epitope derived from MMP-3 elicited immune responses in both subtypes of JIA and in healthy controls. Cytokine pr...

Ngày tải lên: 09/08/2014, 08:23

... Preclinical Pyridoisoquinoline F91873 and F91874 Preclinical Pyrrolopyrazole PHA-E429 Preclinical Indolocarbazole CEP-14083 and CEP-14513 Preclinical No further development Pyrrolopyrimidine GSK1838705A Preclinical No ... results in increased genomic instability by accumulation of DNA SS Bs, and causes hypersensitivity to ionizing radiation and alkylat- ing agents. Additionally, PAR...

Ngày tải lên: 10/08/2014, 21:23

... database. Assessment on timing of introduction of MET service We obtained information from a database maintained by the ANZICS ARCCCR and derived from surveys of ICU resources and activity. The information ... Australian and New Zealand Intensive Care Society (ANZICS) Research Centre for Critical Care Resources (ARCCCR) maintains a database recording information on critical care resourc...

Ngày tải lên: 25/10/2012, 10:35

... not necessarily result in similar changes at the protein level and indicate that UCP3 density in SS and IMF mitochondria can be differently affected by metabolic changes. Keywords: fasting; intermyofibrillar ... Kuhne, Pierre Flandin, Jean-Paul Giacobino and Patrick Muzzin Department of Medical Biochemistry, Faculty of Medicine, University of Geneva, Switzerland Uncoupling protein-3 (U...

Ngày tải lên: 24/03/2014, 04:21

... 'sympathetically maintained pain' [5]. Naturally occurring sympathetic neurotransmitters are cate- cholamines known as norepinephrine, epinephrine, and dopamine. All three substances act within the ... dramatic increase in sensitivity to pain. Low COMT activity may increase pain sensitivity by activating beta (2/3)-adrenergic receptors. The objective of our investigation was to...

Ngày tải lên: 09/08/2014, 10:21

... of Phys- ical Examination. All individuals included in the study were Han Chinese living in and around Nanjing. None dropped out during the study. In addition, a population of 750 Japanese individuals were ... addition, DQS genotyped the samples and participated in the design and analysis of the study, and MN genotyped the Japanese samples. JD, JQ, NJ, YX, CY and JW evaluate...

Ngày tải lên: 09/08/2014, 10:23

... anti-glycosaminoglycan (GAG) antibody binding to the extracellular matrix of hyaline cartilageDetection of anti-glycosaminoglycan (GAG) antibody binding to the extracellular matrix of hyaline cartilage. ... carbohydrate-specific anti- bodies have not yet been systematically investigated in RA, in spite of the fact that hyaline cartilage and synovial fluid contain large amounts of GAGs...

Ngày tải lên: 09/08/2014, 13:22

... complementarity-determin- ing region (CDR3)- typing of T cells infiltrating the joints has been used, aiming to identify clones that are specifically enriched in the inflamed synovia. Some CDR3- ... 1.33% and 2.9% in the total lymphocyte population and within the CD4 + subset, respectively. (Panel b) Treg cells are efficiently removed (0.05% and 1.1% in the total lymphocyte po...

Ngày tải lên: 09/08/2014, 13:22

... circadian increase of proinflammatory cytokine levels, and therefore the consequently observed clinical signs and symptoms of the disease, than to treat these signs and symptoms once they are established ... concentrations, respectively, are modulated by hormones and neuronal pathways coordinated by a subordinate neuroendocrine centre in the hypothalamus, which follows a strict 24...

Ngày tải lên: 09/08/2014, 13:22