Báo cáo y học: " Diagnostic properties of metabolic perturbations in rheumatoid arthritis" pptx

... way of identi- fying the potential role o f metabolic profiling within the field of rheumatology. One of the fields that has driven the development of metabolic profiling is systems biology, in ... complete picture of the findings. Selection of the most discrimina- tory metabolites would almost certainly be required before using a metabolic marker profile in a clinical s...

Ngày tải lên: 12/08/2014, 15:22

... antiproliferative roles of interferons and is induced during growth inhibition in murine cell lines [33]. Recently, Taniguchi et al. [34] showed that cyclin-dependent kinase inhibitor p16 INK4a is induced in RA-SF ... protein 3; FLICE = Fas-associating protein with death domain [FADD]-like interleukin 1β con- verting enzyme [ICE]; FLIP = FLICE inhibitory protein; HD = high-density; HE =...

Ngày tải lên: 09/08/2014, 06:22

... frequent [1], indi- cating a considerable influence of other pro-inflammatory cytokines beside TNF in perpetuating inflammation in RA. IL-15 has been identified as a pro-inflammatory cytokine of potential ... therapy. In this study we investigated the effect of TNF blockade (infliximab) on the synovial expression of IL-15 in RA in relation to different cell types and express...

Ngày tải lên: 09/08/2014, 07:20

... and heavy chain binding protein, both of which are found in early RA and pre-disease sera [29]. Antibody and T-cell reponses to heavy chain binding protein have been identified both in patients ... and maintenance of B cells in arthritic joints, thus representing potential therapeutic targets. For example, blockade of surface lymphotoxin using a decoy lymphotoxin receptor- immunog...

Ngày tải lên: 09/08/2014, 10:20

... presentation in induction and maintenance of RA DC play an essential role in the priming of lymphocytes in autoimmunity [8,77]. Presentation of viral or modified self- antigens, of which the immune system ... gene to modify RA severity. An association with a functional polymorphism with a gene encoding the peptidyl- arginine deiminase enzyme (PADI4), which catalyses citrul- lina...

Ngày tải lên: 09/08/2014, 10:20

... expression of β-catenin in joint tissues of patients with RA, but high expression of the inhibitor of Wnt/β-catenin signaling, DKK-1, in the inflamed synovium, especially in the synoviocytes and synovial ... cytokines are produced in the inflamed synovium as a result of the influx of inflammatory cells from the circulation and synovial cell hyperplasia. The upregulation o...

Ngày tải lên: 09/08/2014, 10:21

... use of a fully humanized anti-IL-15 antibody in clinical trials [56-58]. Interleukin-18 In the RA synovial membrane, this cytokine of the IL-1 family is expressed in CD68 + Mφ contained in lymphoid ... inhibitor of IL-18) and reduced sensitivity to stimulation with IL-12/IL-18, indicating profound dysregulation of the IL-18 system [61]. Interleukin-23 The genuine role of IL-...

Ngày tải lên: 09/08/2014, 10:22

Ngày tải lên: 09/08/2014, 10:22

... Forslind K, Ljung L, Oding R, Chatzidionysiou A, Wörnert M, Bratt J: Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid ... RA, duration in study, duration on treatment) and deter- minedthatnon-lineartermsoffered no advantage over linear terms. In addition, we conducted sensitivity ana- lyses usin...

Ngày tải lên: 12/08/2014, 11:23

... Toshiya Sato, PhD, Professor of Biostatistics, Graduate School of Medicine, Kyoto University, for advising on the statistical analysis. References 1. Toyras J, Lyyra-Laitinen T, Niinimaki M, Lindgren ... of Medicine, Kyoto University, 54 Kawahara-Cho, Shogoin, Sakyo-Ku, Kyoto 606-8507, Japan 3 Department of Applied Medical Engineering Science, Graduate School of Medicine, Yamaguchi...

Ngày tải lên: 09/08/2014, 10:23