Báo cáo y học: "Dual role of interleukin-17 in pannus growth and osteoclastogenesis in rheumatoid arthritis" pps

... mechanism involving COX2 and PGE 2 expression in the resolution of inflammation. Proinflammatory cytokines, including IL-17 and TNF-a, play a critical role i n the pr ogression of synovitis and joint ... production by ST- derived inflammatory cells in the presence of indomethacin Rheumatoid ST contains a number o f proinflammatory cytokines that influence osteoclast format...

Ngày tải lên: 12/08/2014, 15:22

... RNA binding protein that increases HIV expression and replication by inhibiting PKR and by increasing translation of structured RNAs. A recent report published in the Journal of Virology shows ... two-hybrid assay, they map the interaction to the C-terminal domain in TRBP, which is devoid of RNA binding activity, providing further evidence of a direct interaction between the t...

Ngày tải lên: 13/08/2014, 09:21

... the role of cytokines in RP, either in patients or in the corresponding animal models. In the CIA model, several cytokines have been shown to play major roles in the inflammatory process, anti-inflammatory mediators ... cartilage. Staining with hematoxylin and erythrosine. Original magnification ×200. Figure 3 Titers of antibodies to matrilin-1 in mice immunized with matr...

Ngày tải lên: 09/08/2014, 01:24

... obtained by ELISAs. The proinflammatory roles were assessed by the growth- promoting and cytokine-inducing effects of the corresponding recombinant proteins on cultured fibroblast-like synoviocytes ... members in the present study. In RA-BMMCs, EGF and TGFα were also Stimulatory activity of AREG on cytokine production by RA-FLSFigure 4 Stimulatory activity of AREG on cytokine p...

Ngày tải lên: 11/08/2014, 08:21

... A1-Pi and antichymotrypsin are upregulated mainly by a later wave of cytokines such as those of the IL-6 family (IL-6 and onco- statin M), suggesting that these different inhibitors might be physiologically ... macrophages, suggesting a regulation of SLPI at the interface between innate and adaptive immunity [17 •• ]. Role of SLPI and elafin in innate immunity In additio...

Ngày tải lên: 12/08/2014, 18:20

... Groningen, the Netherlands) in order to obtain a recombinant protein containing the C-myc epitope followed by six histidines at the C-terminus. A plasmid containing the wild type version of CCR5 ... buffer and analysed by Western blot with the anti-myc Ig. Besides the 38 kDa band corres- ponding to CCR5-myc-his which is present in lane a, the heavy and light chains of the anti-CD4...

Ngày tải lên: 08/03/2014, 09:20

... exacerbation of SCD, such as hypoxia, hypovole- mia, hypothermia and hyperviscosity, were prev ented by monitoring his vital signs and maintaining them within tight ranges. Anaesthesia from the beginning ... Pediatric Intermediate Care Unit. Pain was managed using Para- cetamol and Piritramid intravenously as needed. After the surgery, the boy complained of a relapsing upper abdomin...

Ngày tải lên: 11/08/2014, 12:20

... obesity, and hypertension in women with RA; and abdominal obesity, high TG levels, and hypertension in healthy controls (Tables 2 and 3). Table 1 A summary of the definitions of the metabolic syndrome JC ... Kulinskaya E, Gough A, Norton S, Dixey J, Early Rheumatoid Arthritis Study (ERAS) group: Mortality in rheumatoid arthritis. Increased in the early course of dise...

Ngày tải lên: 12/08/2014, 15:22

... COOH-terminus (BRCT) domain in its NH 2 -terminal region, as well as an Mre11-binding domain and an ATM-binding domain in its COOH- terminal region (Fig. 1). FHA and BRCT domains are often present in ... ATM and the recruitment of ATM to sites of DNA damage, thereby promoting ATM-dependent signaling [23]. Domains similar to the ATM-binding domain of Nbs1 are also found in...

Ngày tải lên: 16/03/2014, 13:20

... formed. Insertion of molecular dioxygen subsequently yields a LOX ⁄ fatty acid hydroperoxy radical complex (E 2+ – SOO Á ). Both catalytic intermediates contain the enzyme in its catalytically silent ... methyl terminus of the fatty acid impairs substrate binding. It has been sugges- ted before that burying a polar group in the hydropho- bic environment of the substrate binding-pock...

Ngày tải lên: 16/03/2014, 19:20