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Báo cáo y học: " What have we learned from clinical trials in primary Sjögren’s syndrome about pathogenesis" ppsx

Báo cáo y học:

Báo cáo y học: " What have we learned from clinical trials in primary Sjögren’s syndrome about pathogenesis" ppsx

... activating factor, B-cell activation, proliferation and survival constitutes a major pathogenic route in pSS.© 2010 BioMed Central Ltd What have we learned from clinical trials in primary Sjögren’s ... blocking TNFα in pSS [20].  e role of IFNα is discussed in the next section.IFNα in primary Sjögren’s syndrome: a double-edged sword? ere is increasing interest in the role of IFNα in pSS. ... currently available and clinical trials in systemic lupus erythematosus and dermato-myositis/polymyositis are underway.  ere are strong arguments, as discussed above, to design clinical trials...
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báo cáo hóa học:

báo cáo hóa học:" HIV prevention: What have we learned from community experiences in concentrated epidemics?" pdf

... who have difficulty in availing of health-facility based voluntary counselling and testing services.Repeated testing may be useful to reach individuals dur-ing the period of primary HIV infection ... ofongoing transmission is particularly high, due to sharplyelevated viral load [52]. The role of primary infection in the epidemic dynamics was highlighted last year in aCanadian study. Phylogenetic ... intercourse, from 20% in thenineties to 33% in 2007 [12]. Similar relapses in riskbehaviour have been observed in other countries [13,14].The gay community has been widely criticized for insuffi-cient...
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Báo cáo sinh học:

Báo cáo sinh học: " What have we found out about the influenza A (H1N1) 2009 pandemic virus" doc

... lower affinity than did the 1918 virus HA. This was attributed to amino acid differ ences in the HA binding site. Lower binding affinity could affect the degree of inflammation and pathology ... influenza infection, this could be relatively minor in humans, possibly because of the relatively low binding affinity of the influenza A (H1N1) 2009 viral HA for human receptors. Human influenza ... colleagues used a glycan array to compare glycan binding of HAs from influenza A (H1N1) 2009 and 1918 Spanish influenza [12], both showed the same binding specificity and pattern, but the influenza...
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Báo cáo y học:

Báo cáo y học: "What do we know about communicating risk? A brief review and suggestion for contextualising serious, but rare, risk, and the example of cox-2 selective and non-selective NSAIDs" pot

... relativeFigure 4Risk of myopathy, rhabdomyolysis and death from rhabdomyolysis with statins [65]Risk of myopathy, rhabdomyolysis and death from rhabdomyolysis with statins [65].Figure 5Risk ... obviously skewed to older people), and death from any accident (about 1 in 2,000). Low risks include death from an automobile accident (about 1 in 20,000) or from any fall (about 1 in 70,000). Very ... risks include death from firearm (about 1 in 300,000) or in a cataclysmic storm or lightning (about 1 in 3,000,000).Data on risk of mortality from medical interventions were taken from systematic...
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Báo cáo y học:

Báo cáo y học: " What have transgenic and knockout animals taught us about respiratory disease?" pot

... attempting to define novel targets involved in the intra-cellular signalling pathways used by cytokines andchemokines that can be readily tested in murine models.Moreover, strategies attempting ... ofthe clinical condition [18]. If we bear these caveats in mind, important information on the roles of individualcytokines and chemokines, or groups of these sub-stances, in the inflammatory response ... cancer. What we have learned from these modelsIt is immediately obvious that our understanding of therole of the immune system in the initiation and propaga-tion of the inflammatory response in...
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Báo cáo y học:

Báo cáo y học: "Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjögren''''s syndro" pdf

... disordercharacterized by lymphocytic infiltrates of the exocrine glands.Patients present clinical symptoms of dry eyes and dry mouth.The exocrinopathy may occur alone (primary SS) or in associ-ation with ... PNAd,facilitating homing of these naïve lymphocytes [37]. Previousstudies have reported a prominent role for the LTR pathway in maintaining the HEV structures in a functional state in lymphnodes ... followed in NODmice that were given lymphotoxin-beta receptor-immunoglobulinfusion protein (LTR-Ig) starting at 9 weeks of age. Treatmentwas given as a single weekly dose for 3, 7, or 10 weeks....
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Báo cáo y học:

Báo cáo y học: "Effect of infliximab on mRNA expression profiles in synovial tissue of rheumatoid arthritis patients" ppsx

... group.Interestingly, the effect was even stronger in the group in whichTNF-α was immunohistochemically detected before therapy.Here, 1,058 genes were differentially expressed, including manythat ... varia-tions in this respect between different patients [2]. Since themain inflammatory processes occur in the inflamed synovialtissue, it is assumed that detailed analysis of molecular events in inflamed ... reference design allows more flexibility in down-stream analysis [28].Data analysisData were analyzed as previously described [24]. Briefly, thedata were mainly analyzed with the help of software...
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Báo cáo y học:

Báo cáo y học: "Utilization and spending trends for antiretroviral medications in the U.S. Medicaid program from 1991 to 2005" docx

... patients in non-experimental settings have demonstrated thatpatients using HAART therapy have substantially lowermortality rates than those not using it.During the study period, more than twenty ... percent in New Jersey [22,23].Secondly, rising utilization can be explained by decliningmortality rates, leading to individuals' requiring more pre-scriptions over life's course. Using ... Kelton2, Xing Li1 and Jeff J Guo*1,3,4Address: 1College of Pharmacy, University of Cincinnati Medical Center, Cincinnati, Ohio, USA, 2College of Business, University of Cincinnati, Cincinnati,...
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Báo cáo y học:

Báo cáo y học: "T1-nerve root neuroma presenting with apical mass and Horner''''s syndrome" pps

... characterizedby electromyography, which will also demonstrate thechronic reinnervation phenomenon. In our patient, the initial clinical findings were not suffi-cient to explain the ulnar motor neuropathy, ... later.During the subsequent two years following his initialtraumatic episode, his hand weakness worsened, particu-larly in the winter and subsided in the summer. However,during the last two years ... finger paraesthesia during the night, mainly on theright.Neurological examination of the left upper extremityrevealed mild hypotrophy of the ulnar flexors and intrin-sic hand muscles (hypothenar...
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Báo cáo y học:

Báo cáo y học: "Allogeneic hematopoietic stem cell transplantation for acute leukemia with Gilbert’s syndrome" pptx

... cytarabine, and obtained CR in thefirst cycle. His bilirubin level was normal before che-motherapy; however, mild non-hemolytic indirect hyper-bilirubinemia happened to him during each cycle ... condi-tions, but GS is not very frequently considered [2]. In our case, we initially attributed hyperbilirubinemia todrug-induced liver damage in the first two cycles ofchemotherapy.* Correspondence: ... rarely reported. Here we described a case whose transaminase levels were almost normal, althoughtransient hyperbilirubinemia repeatedly happened during chemotherapy.To the editor: We have seen...
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