Báo cáo y học: "mPGES-1 null mice are resistant to bleomycininduced skin fibrosis" docx
Báo cáo y học: "mPGES-1 null mice are resistant to bleomycininduced skin fibrosis" docx
... protein expression was elevated in systemic sclerosis (SSc) fibroblasts and in bleomycin-exposed mice. Compared to WT mice, mPGES-1 -null mice were resistant to bleomycin-induced inflammation, cutaneous ... early-onset disease. Microsomal prostaglandin E 2 synthases (mPGESs) are enzymes that catalyze the conversion of PGH 2 to PGE 2 [6]. Thus far, t hree PGE synthases - namely...
Ngày tải lên: 12/08/2014, 15:22
Báo cáo y học: "BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance" ppt
... the phenotypes can hardly be explained by the SNPs and the few immunoreg- ulatory genes that are expressed differentially in both naïve and immunized BALB/cJ and BALB/cByJ mice. Similarly, 8 of ... as-yet-unknown function may affect or modify clinical phenotypes of arthritis and/ or spondylitis. Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disease that leads to inflamma...
Ngày tải lên: 09/08/2014, 01:22
Báo cáo y học: "NPAS2 and PER2 are linked to risk factors of the metabolic syndrome" pps
... Biosystems 7300 Real Time PCR System (Applied Biosystems, Foster City, California, USA) according to the instructions pro- vided by the manufacturer. Custom TaqMan ® SNP Genotyping Assays were ... J Biol Rhythms 2003, 18:250-60. 3. Ukai H, Kobayashi TJ, Nagano M, Masumoto KH, Sujino M, Kondo T, Yagita K, Shigeyoshi Y, Ueda HR: Melanopsin-dependent photo- perturbation reveals desynchroniza...
Ngày tải lên: 10/08/2014, 09:20
Báo cáo y học: "Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension" pptx
... TSP-1 -/- mice. They only received antibiotics while they were housed prior to hypoxia. Nei- ther WT nor TSP-1 -/- mice group received antibiotics while they were exposed to hypoxia. A total of ... antibiotics we were not able to con- firm any pulmonary vascular remodeling compared to the pulmonary vascular smooth muscle cell hyperplasia reported in TSP-1 -/- mice previously by C...
Ngày tải lên: 10/08/2014, 09:22
Báo cáo y học: "Correction: mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis" pps
... content and myo broblast formation in vivo. (a) Hydroxyproline analysis showed reduced collagen content in mPGES-1 null mice compared with wild-type (WT) mice in response to bleomycin treatment. ... mice per group are shown. (b, c) Immunohistochemistry using anti-α-SMA antibody was performed. mPGES-1 null mice showed a reduced number of α-SMA-expressing myo broblasts compa...
Ngày tải lên: 12/08/2014, 15:22
Báo cáo y học: "PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers"
... cells? Because PARP-1 -null mice are viable and healthy [32], and inhibitors that are specific for PARP-1 are relatively non-toxic and do not directly damage DNA, PARP-1 inhibitors might be both ... with cytotoxic drugs by increasing the sensitivity of the tumors to these agents. Indeed, it has been shown that PARP-1 inhibitors not only significantly enhance the anti-tumor effi...
Ngày tải lên: 31/10/2012, 16:57
Báo cáo Y học: Rodent a-chymases are elastase-like proteases pot
... specificity and inhibitor profiles, rodent a-chy- mases are elastase-like serine proteases. To our knowledge, the mast cell chymases that have been enzymatically characterized to date are all chymotrypsin-like ... the allergic inflammatory reaction to exclude antigens by releasing various inflammatory mediators, and they con- tribute to the development and modulation of other inflammat...
Ngày tải lên: 08/03/2014, 09:20
Báo cáo y học: "QTc and psychopharmacs: are there any differences between monotherapy and polytherapy" ppsx
... purposes) Annals of General Psychiatry Open Access Primary research QTc and psychopharmacs: are there any differences between monotherapy and polytherapy Jadranka Жulav Sumić*, Vesna Barić † , ... related to psychoactive drug treatment: a com- parison of monotherapy versus polytherapy. Ann Gen Psychiatry 2005, 4:1. 27. WHO: Collaborating Centre for Drug Statistics Methodol- ogy; ATC Inde...
Ngày tải lên: 08/08/2014, 21:20
Báo cáo y học: "Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study" pptx
... the efficacy and safety of selective COX-2 inhibitors were conducted in relatively young, healthy subjects. Our study suggests that these may not be the patients who are especially at risk for ... and regulates normal physiology, such as the maintenance of gastric mucosal integrity. Conversely, COX-2 is expressed selectively after exposure to inflammatory media- tors or trauma, and has .....
Ngày tải lên: 09/08/2014, 10:20
Báo cáo y học: "Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice" pot
... the same area as demonstrated by the use of adjacent sections. mRNA levels of pro-inflammatory cytokine genes are differentially upregulated in both adipose and liver tissues of HFC-fed mice A ... Release of inflammatory mediators by human adipose tissue is enhanced in obesity and primarily by the nonfat cells: a review. Mediators Inflamm 2010, 513948. 18. Juge-Aubry CE, Somm E, Chichepor...
Ngày tải lên: 11/08/2014, 03:20