Báo cáo y học: "Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts" ppt

... chemokines and cytokines by fibroblasts, which subsequently can increase the inflammatory infiltration of the tissue. In this study, IFNa2 upregulated TLR3 and T LR3-induced IL-6 production. The increase ... expression in systemic sclerosis. J Invest Dermatol 2010, 130 :25 83- 25 93. doi:10.1186/ar3221 Cite this article as: Agarwal et al.: Toll-like receptor 3 upregulation...

Ngày tải lên: 12/08/2014, 15:22

... synthesis and homeostasis in cartilage. Interestingly, adult mice fed diets deficient in vitamin A exhibit generalized increases in basal NF-κB activity [21]. Upon administration of retinoic acid, ... p300. p300 is phosphor- ylated in both the carboxyl-terminal and amino-terminal regions by a kinase in the MEKK1 pathway, resulting in increased acetylase activity [33 ]. In...

Ngày tải lên: 09/08/2014, 10:22

... before controlling for NA – but it did predict PTSD severity in men and remained significant even at the final level of analysis. This is in line with the findings by Bromet et al. [ 13] . However, it is important ... remaining significant in the original model again failed to remain significant when NA and dissociation were controlled for. NA and dissociation were both highly s...

Ngày tải lên: 08/08/2014, 23:21

... to its inhibitory effect on Figure 2 Effect of retinoids on interleukin-1-beta (IL-1β)-induced expression of IL-6 in synovial fibroblastsEffect of retinoids on interleukin-1-beta (IL-1β)-induced ... Takahashi N, Liapi C, Anderson WB, Breitman TR: Retinoylation of the cAMP-binding regulatory subunits of type I and type II cAMP-dependent protein kinases in HL60 cells. Arch Biochem B...

Ngày tải lên: 09/08/2014, 01:22

... attenuating the activity of inflammatory cytokines in patients with RA inhibits bone resorption and destruction. IL- 23, which was recently identified as a heterodimeric, proin- flammatory cytokine and ... proinflammatory cytokines including TNF-α, IL-1β, and IL-6 is markedly reduced in IL- 23- deficient (IL- 23 p19 -/- ) mice [16]. These cytokines promote bone resorption by indu...

Ngày tải lên: 09/08/2014, 10:21

... (http://creativecommons.org/licenses /by/ 2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Racial and ethnic disparities in ... perceptions of quality of chronic knee or hip pain: dif- ferences by ethnicity and relationship to clinical variables. J Gerontol A Biol Sci Med Sci 2...

Ngày tải lên: 09/08/2014, 14:21

... Hippel P: Selection of DNA binding sites by regu- latory proteins. II. The binding specificity of cyclic AMP receptor protein to recognition sites. J Mol Biol 1988, 200:709-7 23. 32 . Regulatory ... positions that are not in the motif (background positions) are independent and identically distributed according to a multinomial distribution. Bases in positions that are in the moti...

Ngày tải lên: 09/08/2014, 20:20

... nuclear interior within 15 minutes (Figure 4h and l), with an intermediate -type nuclear positioning visible in the intervening time points (5 and 10 minutes; Figure 4f, g, j, and k). In addition, chromosome ... sup- ported by experiments using inhibitors of ATPase and GTPase, as well as inhibitors of actin and myosin polym- erization. The actin polymerization inhibitor phall...

Ngày tải lên: 09/08/2014, 20:21