... expression increased in the aging thymus. The CCR5 ligands, CCL4 and CCL5, increase in the thymic parenchyma as revealed by the age-associated increases in the staining of thymocytes and microenvironmental ... proin-flammatory cytokines and fat-derived peptides termed adipokines (including ligands such as adi-ponectin, leptin, resistin, TNF-α, IL-6), which act in a paracrine, autocrine and/ or endocrine ... advancing age lead to a novel con-ceptual point of view concerning the understanding of the process of thymic physiology in aging, where the increase in adipocytes an fat-bearing cells may Int....