Báo cáo y học: "Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin21-157" docx
Báo cáo y học: "Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis" pdf
... expression and function in chondrocytes. The objective of this study was toevaluate the expression of 15-lipoxygenase-1 and -2 in human articular chondrocytes, and to investigate the effects of theirmetabolites ... experiments and the PPARγ antagonist GW9662.Results Articular chondrocytes express 15-lipoxygenase-1 and -2 at the mRNA and protein levels. 13(S)-hydroxyoctadecadienoic and 15(S)-hydroxyeicosatetraenoic ... in chondrocytes. Chondrocytes were transiently transfected with a luciferase reporter con-Figure 1Human articular chondrocytes express both 15-LOX-1 and 15-LOX-2Human articular chondrocytes express...
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Báo cáo y học: "Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin21-157" docx
... et al.: Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin21-157. Arthritis Research & Therapy 201012:R228.Berg ... the type of ligand it binds. In the present study, we aimed to clarify whether human chondrocytes express ChemR23 and chemerin, and whether chemerin /ChemR23 signalling could affect secretion of inflammatory ... bind the ChemR23 receptor expressed by chondrocytes whichpromote their secretion of pro -inflammatory cytokine s and MMPs.Figure 5 The presence of ChemR23 and chemerin in cultured human articular...
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Báo cáo y học: "Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13" ppsx
... PCRspecificity was confirmed by dissociation curve analysis (datanot shown).IL-7 binding assayFor flow cytometry analysis, chondrocytes were removed fromsix-well dishes by trypsin digestion and for ... Medium was analyed for sulfated glycosaminoglycan (sGAG) using the dimeth-ylmethylene blue assay and normalized for the wet weight of the tissue. (b) Total nitrite was measured in the media as ... catabolicactivity [2]. In addition to inducing matrix degrading enzymesdirectly, these cytokines can also act by stimulating productionof additional proinflammatory cytokines. IL-6 is among the cytokines...
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Báo cáo y học: "Human meniscus cells express hypoxia inducible factor-1α and increased SOX9 in response to low oxygen tension in cell aggregate culture" ppsx
... procurement and Figure 5Collagen P4H isoenzyme gene expression in articular chondrocytes aggregatesCollagen P4H isoenzyme gene expression in articular chondrocytes aggregates. Prolyl 4-hydroxylase ... articular chondrocytes existin a completely avascular microenvironment, and an oxygenFigure 3Collagen types I and II, and SOX9 gene expression in human articular chondrocytesCollagen types I and ... clearly not modulated in aggre-gate cultures of articular chondrocytes by 5% oxygen tension.This may therefore reflect a greater sensitivity of meniscuscells to oxygen tension. Naturally, articular...
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báo cáo hóa học:" Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function" ppt
... HBSS.Mixed lymphocyte reaction (MLR)Blood samples were diluted two-fold with PBS and lay-ered onto Ficoll-Hypaque. Each tube was centrifuged at400 g for 30 min and the lymphocytes at the interfacewere ... numbers of CD4+ and CD8+ T cells on pooled samples were determined on days 0, 3, and 6 post-culture by flow cytometry analysis (B). Expression of FoxP3 and CD25 were determined in freshly isolated ... (Pepro-tech) for 3 days and expression of Foxp3 was determinedusing flow cytometry analysis. Expression of FoxP3 wasalso determined on freshly isolated T cells on day 0. AsBioMed CentralPage...
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Báo cáo y học: "Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action" pps
... othercytokines (e.g. IL-8, IL-6, and leukotriene inhibitory factor),proteases, and prostaglandin E2(PGE2) [30]. Synthesis of the inflammatory cytokines IL-1 and TNF-α and expressionof their ... by the proinflammatorycytokines IL-1 and TNF-α [29–31,36]. NO may be involvedin cartilage catabolism by inhibiting the synthesis of colla-gen and PG, enhancing MMP activity, reducing the synthe-sis ... found in chondrocytes or the articular cartilage surface in OA [29,31]. The activity ofmany MMPs increases in OA by either an increase in theirown synthesis, an increased activation by their proen-zymes,...
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Báo cáo y học: "Ultrasonography, magnetic resonance imaging, radiography, and clinical assessment of inflammatory and destructive changes in fingers and toes of patients with psoriatic arthritis" pot
... examined by US, 300 by MRI, and 795 by x-ray.Ultrasonography observations in PsA and RA patients and CTRLs The observations by US in PsA and RA patients and CTRLsare listed in Table 1. In particular, ... PsA.Observations by ultrasonography, MRI, and x-ray in the MRI-examined hand The observations by US, MRI, and x-ray in the MRI-examinedhand are listed in Table 2. Both US and MRI were more ... properly cited.Abstract The aim of the present study was to assess ultrasonography(US) for the detection of inflammatory and destructive changesin finger and toe joints, tendons, and entheses...
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Báo cáo y học: "An intervention to improve paediatric and newborn care in Kenyan district hospitals: Understanding the context" ppsx
... purposes)Acknowledgements The authors are grateful to the staff of all the hospitals included in the study and colleagues from the Ministry of Public Health and Sanitation, the Minis-try of Medical Services and the ... (hospitals H1,H4 and H5) there was often only one nurse on duty on the paediatric ward, and even during the day it was rare for anurse to be specifically assigned to the newborn nursery.Hospitals ... somereassurance that the process of randomization helpedachieve group balance, the highly dynamic reality of hos-pitals evidenced by the prospectively organized approachto description underscores the need...
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Báo cáo y học: " Returning home: forced conscription, reintegration, and mental health status of former abductees of the Lord''''s Resistance Army in northern Uganda" pps
... contributionsPNP and PV designed the study, conducted the field studyin Uganda, and analyzed the data. PNP, PV, and ES inter-preted the data and wrote the report. All authors read and approved the final ... captivity for less than one day were releasedby the LRA. The LRA may have abducted as many peopleas they could during a raid to help them carry stolen goods and also enable them to select the fittest ... manuscript.Acknowledgements The research was supported by grants from the John D. and Catherine T. MacArthur Foundation and Humanity United. The sponsors of the study had no role in the design of the study, data...
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Báo cáo y học: "Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis" potx
... IL-1β and TNF-α are the keyproinflammatory cytokines mediating cartilage degradation inpatients with RA and OA. IL-1β and TNFα participate in theseprocesses by stimulating chondrocytes and synoviocytes ... The proinflam-matory cytokines in turn stimulate articular chondrocytes and synoviocytes to produce matrix-degrading enzymes such asmatrix metalloproteinases (MMPs) and proinflammatoryenzymes ... purposes)quently they may also influence inflammatory and apoptoticpathways using other mechanisms.Further in vitro and in vivo studies in animals and humans willbe required to determine the full...
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngBáo cáo quy trình mua hàng CT CP Công Nghệ NPVchuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Chuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ