Báo cáo y học: "Promise and pitfalls of the Immunochip" docx

... an unlikely source of much missing heritability. Of the 95 loci known by SNP studies at the end of 2009 to be associated with Crohn’s disease and type 1 and type 2 diabetes, only three harbored ...  ese fi ndings have greatly advanced our understanding of the basic causes of autoimmune and infl ammatory conditions, and have provided a solid foundation for hypothes...

Ngày tải lên: 12/08/2014, 15:22

... age of 8 years, the top of the frontal sinuses is at the level of the orbital roof, and by the age of 10 years, the sinuses extend into the vertical portion of the frontal bone. The final ... By the age of 4 years, the average cranial extent of the frontal sinus reaches half the height of the orbit and extends just above the top of the...

Ngày tải lên: 25/10/2012, 11:04

... anandamide and 2-arachidonoylglycerol (2-AG), the cannabinoid CB 1 and CB 2 receptors, and one of the enzymes mostly responsible for endocannabinoid hydrolysis, the fatty acid amide hydrolase (FAAH). By ... macrophages and lymphocytes as far as the amounts of the endogenous ligands are concerned, but differently in terms of the levels of the two cannabinoid recep...

Ngày tải lên: 22/02/2014, 07:20

... detailed analysis of the expression of the Nicn1 gene at days 8.5, 9.5, and 10.5 of murine development was performed by in situ hybridization of digoxigenin-labeled riboprobes to whole- mount mouse embryos. ... of the organ. As the RNA for the Northern blot and the RT-PCR analysis had been derived from two different anonymous human donors the differ- ences in the...

Ngày tải lên: 23/03/2014, 21:20

... investigations of the scission of calf thymus DNA catalyzed by bleomycin A 5 (BLM-A 5 ) in the presence of ferrous ion and oxygen. The molar reaction enthalpy for the cleavage, the Michaelis– Menten ... double-strand breakage of DNA molecules by oxidation of the deoxyri- bose moiety in the presence of oxygen and a redox-active metal ion, e.g. Fe and Co [2–6]. O...

Ngày tải lên: 24/03/2014, 04:21

... in the design and revision of the study and performed the statistical analysis. RP participated in the design and revision of the study. AS partic- ipated in the analysis and interpretation of ... and helped to draft the manuscript. RR participated in the design of the study and in the revision of the manuscript. EP participated in analy- sis of d...

Ngày tải lên: 09/08/2014, 08:22

... to the conception of the study, and the acqui- sition, analysis and interpretation of the data, and participated in drafting the manuscript. PSP contributed to the conception of the study, and ... from that of a random population, and they may have a tendency to exaggerate self-perceived severity. The repeatability of the FAS index was excellent, as shown...

Ngày tải lên: 09/08/2014, 14:22

... 117 and B = 1.0 ± 0.15. Figure 5 Size of the pan-genome versus the number of polymorphic sites. The slope of the fitted line gives the ratio between the rate of acquisition of new genes and the ... of the S. mitis genomes (average gen ome length of 1,949,224 bp), and 53% and 55% of the S. oralis and S. infantis genomes, respectively. Of these, 283...

Ngày tải lên: 09/08/2014, 22:23

... particular physiological state (Figure 1). Since the steady-state level of mRNA ca n vary and is a function of RNA synthesis and decay, the control of mRNA stability plays an essential role in the regulation of ... Singh 1† and Sue Lin-Chao 1* Abstract RNA synthesis and decay counteract each other and therefore inversely regulate gene expression in pro- and eukaryoti...

Ngày tải lên: 10/08/2014, 05:21

... species is the lack of knowledge on fundamental aspects of the family be havioural ecology, such as the type of habitats that the birds prefer, how they interact with each other, and how they establish territories ... at the rainy sea- son. They are built with wood or clay and covered with the straw of the babasu palm (Orrbignya speciosa). In most cases, the procur...

Ngày tải lên: 10/08/2014, 09:21