Báo cáo y học: "Anticitrullinated protein antibody (ACPA) in rheumatoid arthritis: influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione s-transferase in a cross-sectional study" ppt

... Anticitrullinated protein antibody (ACPA) in rheumatoid arthritis: influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione s- transferase in a cross-sectional ... Ghelani AM, Samanta A, Jones AC, Mastana SS: Association analysis of TNFR2, VDR, A2 M, GSTT1, GSTM1, and ACE genes with rheumatoid...

Ngày tải lên: 12/08/2014, 15:22

... and/ or failed disease-modifying antirheumatic drug (DMARD) therapy at entry and length of study. a Standard deviation not reported. ABA, abatacept; ADA, adalimumab; AIM, Abatacept in Inadequate ... Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: system- atic review and meta-analysis of rare harmful effects in r...

Ngày tải lên: 09/08/2014, 01:22

... expressed predominantly on the MLS and FLS in the lining and sublining layers of RA synovium, and macrophages acted as the ampli- fier of the pathogenetic cascade in RA via the increase of MMP production by ... autoradiography. (a) and (b) Expression of CD147, MMP-2 and MMP-9 mRNA in RA FLS (lanes 1, 3 and 2) was higher than that in OA FLS (lanes 4, 6 and 5). (a...

Ngày tải lên: 09/08/2014, 07:20

... 50:62-65. 7. Nakashima H, Inoue H, Akahoshi M, Tanaka Y, Yamaoka K, Ogami E, Nagano S, Arinobu Y, Niiro H, Otsuka T, et al.: The combination of polymorphisms within interferon-gamma receptor 1 and receptor ... time of the analysis was 63 years (17–81 years), and 76% were female. A cohort of 171 healthy individuals matched on the basis of age, sex and origin were used as a...

Ngày tải lên: 09/08/2014, 07:20

... competing interests. Authors' contributions TK performed study design, data analysis, manuscript drafting, and data acquisition. JSS and DA performed study design, data analysis, and manuscript ... (a) and tender (b) 28-joint counts and 32-joint counts and an almost perfect linear relationship between DAS28 and 'DAS32' (c) or SDAI and 'SDAI32' (...

Ngày tải lên: 09/08/2014, 10:20

... single disorder. Biomarkers and clinical markers Disease activity, joint damage and functional impairment form the anchor points of the natural history of RA, and are characterized by a triangular interrelationship ... Visvanathan S, Marini JC, Smolen JS, Clair EW, Pritchard C, Shergy W, Pendley C, Baker D, Bala M, Gathany T, Han J, Wagner C: Changes in biomarkers of inflammat...

Ngày tải lên: 09/08/2014, 10:23

... indicate that alterations in the balance of HAT and HDAC activity may also contribute to perpetuation of inflammation in RA. In a small study examining synovial tissue obtained during joint replacement ... were again mirrored by an increase in synovial cell histone acetylation, induction of synovial p16 Ink4 and p21 Waf1 expression, and decreased TNFα synthesis. SAHA...

Ngày tải lên: 09/08/2014, 11:20

... I, Kumagai S: Meta-analysis: diagnostic accuracy of anticyclic- ncitrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med 2007, 146:797-808. 4. Avouac J, ... van Vollenhoven RF: Longitudinal analysis of citrul- linated protein/ peptide antibodies (anti-CP) during 5 year follow up in early rheumatoid arthritis: anti-CP status predicts wor...

Ngày tải lên: 09/08/2014, 14:22

Ngày tải lên: 12/08/2014, 19:22

... design, data analysis and interpretation, and writing of the manuscript. DF, MS and FW were involved in data analysis and interpretation, and writing of the manuscript. WK was involved in study design ... and data analysis. BE was involved in study design and data collection. UM was involved in data management, statistical analysis and data interpretation. RS was i...

Ngày tải lên: 13/08/2014, 21:21