Báo cáo y học: "Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex" potx
Báo cáo y học: "Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex" potx
... purposes) Respiratory Research Open Access Research Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase -inhibitor ... carry a high positive charge) were used to assess whether the degree of binding to SLPI by the protei- nase or its ability to associate wi...
Ngày tải lên: 12/08/2014, 15:21
Báo cáo y học: " Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B" pps
... significantly decreased by pre-treatment of COX-2 specific inhibitor, but not by COX-1 inhibitor. NTHi induced COX-2 expression was mediated by TLR2 in the epithelial cell in vitro and in the lungs of ... markedly inhibited not only by p38 MAPK inhibitor SB203580, but also by another p38 MAPK inhibitor SB202190, and NF- kappa B inhibitor PDTC. Moreover, PGE2 releas...
Ngày tải lên: 12/08/2014, 15:21
Báo cáo y học: "Neutrophil elastase downmodulates native GCSFR expression and granulocyte-macrophage colony formatio" pot
... lies the ligand-binding site for G- CSF. Notably, proteolytic cleavage of the G-CSFR within this region is predicted to modify the binding site for G- CSF and thereby affect the sensitivity of ... disappearance of the mature 150 kDa receptor spe- cies (F igure 2B, last lane). These findings are consistent with proteolytic degradation of the G-CSFR by NE. Furthermore, th...
Ngày tải lên: 11/08/2014, 08:22
Báo cáo y học: " Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model" ppsx
... agent, significantly inhibited the systemic release of these cytokines, which mediate the lethality of ALI and systemic The effect of ethyl pyruvate on permeability index in ALIFigure 1 The effect of ethyl pyruvate ... indices of the injured lungs (Fig. 1). Administration of high dose EP prevents the lethality of ALI and reduces the permeability index To evaluate...
Ngày tải lên: 12/08/2014, 14:20
Báo cáo y học: " Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo" pot
... Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination. EMBO J 1997, 16:6325-636. 29. Valentijn JA, Fyfe GK, Canessa CM: Biosynthesis and processing of epithelial ... implying that asODN function mainly in the nucleus, where they bind to mRNA target sequence specifically by forming Watson-Crick base pairs. The mRNA/asODN hybrid is subse...
Ngày tải lên: 12/08/2014, 16:20
Báo cáo sinh học: " Neutrophil elastase, an acid-independent serine protease, facilitates reovirus uncoating and infection in U937 promonocyte cells" pdf
... activity was completely inhib- ited by E64 but largely unaffected by the NE inhibitor. To examine the effect of the NE inhibitor on reovirus rep- lication in U937 cells, we pre-treated them for ... directly examined the capacity of NE to facilitate reo- virus infection by using the irreversible elastase inhibitor, N-(methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ke...
Ngày tải lên: 19/06/2014, 08:20
báo cáo hóa học:" Neutrophil elastase, an acid-independent serine protease, facilitates reovirus uncoating and infection in U937 promonocyte cells" pptx
... activity was completely inhib- ited by E64 but largely unaffected by the NE inhibitor. To examine the effect of the NE inhibitor on reovirus rep- lication in U937 cells, we pre-treated them for ... examined the capacity of NE to facilitate reo- virus infection by using the irreversible elastase inhibitor, N-(methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone [53]...
Ngày tải lên: 20/06/2014, 04:20
Báo cáo y học: "Rituximab therapy reduces activated B cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis: depletion of memory B cells correlates with clinical response" potx
... participated in the design and conduction of the study and drafted the manu- script. PS participated in the design of the study, performed the statistical analysis of the data and drafted the manuscript. GB ... responsible for analysis of flow cytometry experiments. HAP participated in the design of the study and drafted the manuscript. HK participated in the...
Ngày tải lên: 09/08/2014, 14:22
Báo cáo y học: " Neutrophil mediated smooth muscle cell loss precedes allograft vasculopath" pdf
... models, damage to the media appears to be more important that the endothelium in the induction of the neointimal lesion in AV [22]. The role of early SMC loss in the eventual development of AV is unclear. ... therapies on SMC recovery is unknown, but of significant clinical relevance. Conclusion While there is no debate that the endothelium is injured by IR and plays...
Ngày tải lên: 10/08/2014, 09:22
Báo cáo y học: " Neutrophil cannibalism – a back up when the macrophage clearance system is insufficient" pot
... infection by killing and phagocyting pathogens. In the present study, using a model of LPS-induced lung inflammation we propose yet another mechanism by which they contribute to the resolution of inflammation: by ... in the design of the study, played a major role in the acquisition, analysis and interpretation of data, and drafted the manuscript. LU participated...
Ngày tải lên: 12/08/2014, 16:20