... interference BackgroundArginine deiminase depletes arginine by hydrolyzing itto ci trulline. Pegylated recombinant arginine deiminase(rADI) has been used as an anti-cancer drug (ADI-SSPEG 20,000 MW) in clinical ... AccessRNA interference of argininosuccinate synthetaserestores sensitivity to recombinant argininedeiminase (rADI) in resistant cancer cellsFe-Lin Lin Wu1,2,3, Yu-Fen Liang1, Yuan-Chen ... occurred in a wide variety of cells. Accordingly,the different cell lines may also explain the discrepancy.ConclusionsDe novo arginine synthesis via the ci trulline-arginineregeneration pathway...