Báo cáo y học: "RNA interference for CFTR attenuates lung fluid absorption at birth in rats" doc

... 12 (page number not for citation purposes) Respiratory Research Open Access Research RNA interference for CFTR attenuates lung fluid absorption at birth in rats Tianbo Li, Shyny Koshy and Hans G Folkesson* Address: ... during early postnatal development. CFTR maintained a relatively high expression at birth and reached adult levels at the 2 nd postnatal day. In...

Ngày tải lên: 12/08/2014, 15:21

... Granularized data. Probes were grouped as described in [16], and data were averaged for varying annotations (that is, YAL001W-5CDS indicates probes falling within 500 bp of YAL001W’s ATG) as indicated. Additional ... Genome Biology 2010, 11:R75 http://genomebiology.com/2010/11/7/R75 Page 6 of 13 transferred to a 37°C incubator and incubated for vary- ing lengths of time prior to fixatio...

Ngày tải lên: 09/08/2014, 20:22

... present study reveal that MK-886 may ameliorate lung injury in shocked rats via interfering with inflammatory and oxidative pathways implicating the role of leukotrienes in the pathogenesis of hemorrhagic ... considered as an insult fre- quently leading to systemic inflammatory response syn- drome including the systemic release of proinflammatory cytokines which is central in t he inf...

Ngày tải lên: 10/08/2014, 09:21

... interference Background Arginine deiminase depletes arginine by hydrolyzing it to ci trulline. Pegylated recombinant arginine deiminase (rADI) has been used as an anti-cancer drug (ADI-SS PEG 20,000 MW) in clinical ... Access RNA interference of argininosuccinate synthetase restores sensitivity to recombinant arginine deiminase (rADI) in resistant cancer cells Fe-Lin Lin Wu 1,2,3 , Yu...

Ngày tải lên: 10/08/2014, 05:21

... author information is available at the end of the article Kawata et al. Journal of Clinical Bioinformatics 2011, 1:6 http://www.jclinbioinformatics.com/content/1/1/6 JOURNAL OF CLINICAL BIOINFORMATICS © ... resulting in long-term gene silencing. For instance, Takeshita et al. demon- strated that the systemic siRNA delivery with atelocolla- gen existed intact for at least 3 days in...

Ngày tải lên: 10/08/2014, 09:22

... contribute to post- integration latency in HIV-1 infected individuals by recog- nizing target sequences in 3' UTR of viral mRNAs. Thirdly, in another viral system, the hepatitis C virus (HCV), ... host-defenses. The latency-associated transcript (LAT) of herpes simplex virus-1 (HSV-1) is known to inhibit apoptosis and maintain latently infected neurons by generating micro-RNA (miR-...

Ngày tải lên: 13/08/2014, 06:20

... transformed our thinking on the role of RNA in many facets of biology, illustrating the complexity and the dynamic interplay of cellular regulation. As plants and invertebrates lack the protein-based ... defence in vertebrate cells. In addition to demonstrating RNA silencing to be critical to vertebrate innate immunity, these studies also highlight the potential of utilising virus- infe...

Ngày tải lên: 13/08/2014, 09:21

... a phenotype including defective cytokinesis. By searching through the data manually, Bjorklund et al. [9] found that dsRNA-mediated RNAi against eight other components of the insulin/Tor pathway gave ... and CG18081 resemble zinc finger proteins. The insulin signaling pathway leading to activation of the protein kinase Tor is a well known regulator of growth and can alter cell size in both...

Ngày tải lên: 14/08/2014, 16:21

... elements to the telom- ere array is regulated. A recent paper by Savitsky et al. [2] provides intriguing evidence that proteins associated with RNA interference (RNAi) may be involved. Earlier work from ... Firstly, although both RNAs were upregulated specifically in germline cells, they had different patterns of accumulation. The increase in TART RNA was detected in the nurse cells...

Ngày tải lên: 14/08/2014, 16:21

... were completed using the following conditions: 30 minutes at room temperature, 3 hours at 42°C, and 5 minutes at 95°C. For in situ hybridization, the cells were incubated at 65°C for one hour in blocking ... regulation by studying the effects of a coding and non-coding NAT on corresponding gene expression, and to investigate the possible involvement of endogenous RNA interfer...

Ngày tải lên: 14/08/2014, 16:21