Báo cáo y học: " Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis" doc

... overexpression in the lungs of mice We initially characterized cathepsin K overexpression in the lungs of transgenic mice compared to wild-type mice. Analysis of cathepsin K mRNA and protein levels in lysates ... purposes) Effect of bleomycin instillation on leukocyte subset recruitment into the lungs of mice. Figure 4 Effect of bleomycin instillation...

Ngày tải lên: 12/08/2014, 15:21

... extraction. Hydroxyproline assay Collagen deposition was estimated by measuring hydrox- yproline content in lungs homogenized in PBS. Hydroxy- proline was assessed by high-pressure liquid chromatography ... FR, Kaminski N, Eugui E, Allard J, Yakhini Z, Ben Dor A, Lollini L, Morris D, Kim Y, DeLustro B, et al.: Gene expression analysis reveals matrilysin as a key regulator of pulmo...

Ngày tải lên: 12/08/2014, 18:21

... 93:639-644. 22. Yasue H, Yoshimura M, Sumida H, Kikuta K, Kugiyama K, Jouga- saki M, Ogawa H, Okumura K, Mukoyama M, Nakao K: Localiza- tion and mechanism of secretion of B-type natriuretic peptide in comparison ... [2]. Several cytokine signaling molecules, including endothelin-1 and Toll-like receptor, have been speculated to play important roles in the onset of cardiac...

Ngày tải lên: 13/08/2014, 11:22

... allelic association of atopy and markers flanking the IL-4-receptor gene. Clin Exp Allergy 1998, 28 :151-155. 37. Mitsuyasu H, Izuhara K, Mao XQ, Gao PS, Arinobu Y, Enomoto T, Kawai M, Sasaki S, Dake Y, Hamasaki ... Europe have linked Alternaria sensitivity to both persistence and severity of asthma. In order to begin to understand genetic risk factors underlying Alternaria...

Ngày tải lên: 13/08/2014, 13:22

... demethylati on of sarcosine (N-methylglycine) to form glycine and formalde- hyde. Similarly, DAAO catalyses the oxidative d eamination of neutral and (with a lower efficiency) basic D -amino acids to ... oxidizes gly- cine and sarcosine to the corresponding a-keto a cid, ammonia a nd hydrogen peroxide. By inserting the DNA encoding for GO into the multiple cloning site of the...

Ngày tải lên: 08/03/2014, 16:20

... production of TNFa and MIP2 Having detected a trend to ward increased intra-alveolar cytokine and chemokine levels in SPC-sICAM-1 mice compared to wild-type mice in response to in vivo K. pneumoniae infection, ... design and analysis of in vitro assays, dissemination experiments, and analysis of data. JLC designed flow cytometric assays to characterize rec...

Ngày tải lên: 12/08/2014, 13:22

... for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma. J Allergy Clin Immunol 1993, 92:397-403. 11. Cembrzynska-Nowak M, Szklarz E, Inglot AD, Teodorczyk-Injeyan ... Th2 cytokines IL-5 and IL-10 compared to OVA/WT mice. Therefore, NO derived from eNOS might be involved in the attenuated production of both Th1 and Th2 cytokines, resulting in...

Ngày tải lên: 12/08/2014, 16:20

... variety of symptoms and clinical conditions. Background In an era of accountability, health care providers are increasingly required to use reliable and valid outcome measures to assess changes in ... Oswestry Disability Index and Neck Disability Index for assessing functional disability due to low back and neck pain respectively. Standardised questionnaires such as the...

Ngày tải lên: 25/10/2012, 10:06

... 25-guage Quincke needle without intro- ducer and any local infiltration, 90% of them had moderate to severe pain using NRS and nobody had NRS=0 (unpublished observation). According to this pilot ... orally on the morning of surgery. On arrival in the operating room, ECG electrodes and non-invasive blood pressure (NIBP) monitor were applied and oxygen saturation was mon...

Ngày tải lên: 25/10/2012, 11:15

... freeze-drying, was separated by mini-gel columns of Sephadex-G50 prepared in advance. In brief, incubation mixtures of 200μL containing unloaded matrine and RGD-M-LCL were added onto mini-gel ... had increased anti-proliferative activity and increased the induction of apoptosis in cancer cells compared to free matrine, supporting the further development of this novel...

Ngày tải lên: 26/10/2012, 08:57