Báo cáo y học: " Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice" ppt

... of inflammation and pathology were reduced in mice sub- jected to smoke exposure before influenza infection. For example, net gelatinase activity in BALF and numbers of CD4+ and CD8+ lymphocytes ... d3, altered profiles of key cytokines and CD4+ and CD8+ T lymphocytes, worse lung pathology and more virus-specific, activated CD8+ T lymphocytes in BALF. Mice sm...

Ngày tải lên: 12/08/2014, 15:21

... inflammatory response in the lungs of mice which is linked to a reduction in HDAC activity and may be a key mechanism of glucocorticoid insensitivity in COPD [11,17,21]. Both this reduction in HDAC ... com- plexes and thereafter their roles in disease. In summary cigarette smoke exposure reduced HDAC- 2 activity and the expression of mSin3a and Mi-2α in the lun...

Ngày tải lên: 11/08/2014, 03:20

... glucocorti- coid insensitive inflammation in the lungs. We have pre- viously reported that cigarette smoke exposure reduced lung HDAC-2 activity and increased lung KC levels using the same animals and samples ... Protein kinase CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of HDAC2 by cigarette smoke a...

Ngày tải lên: 11/08/2014, 06:22

... [7,9-12] and could be explained by differences in the distribution of ventilation, in tissular stress and strain as Commentary Reducing ventilator-induced lung injury and other organ injury by the ... pathways contribute to clinical symptoms and morbidity, including translocation of inflammatory mediators, endotoxins and bacteria from the lung to the systemic circulation...

Ngày tải lên: 12/08/2014, 23:23

... 8 of 9 (page number not for citation purposes) determining hospital mortality in very long stay ICU patients. Clinical decisions regarding individual very long stay patients clearly require incorporating ... support therapies in cases of futility, this is a complex issue influenced by patient and fam- ily values and with some variability in opinion and practice between individ...

Ngày tải lên: 12/08/2014, 23:23

... 5(4):749-756. 41. Matsunaga K, Klein TW, Friedman H, Yamamoto Y: Involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine responses of alveolar macrophages ... manually-controlled cigarette smoking machine that produces a combination of side- stream and mainstream cigarette smoke in a chamber, which is then transported to...

Ngày tải lên: 12/08/2014, 11:21

... phosphorylation of IRAK and degradation of IκB-α by MDMs and phosphorylation of IRAK in HEK cellsFigure 6 CSM regulates phosphorylation of IRAK and degra- dation of IκB-α by MDMs and phosphorylation of IRAK ... manufacture's instruction. Amplification was achieved using an initial cycle of 50°C for 2 min and 95°C for 15 min, followed by 40 cycles of 95°C for...

Ngày tải lên: 11/08/2014, 08:22

... Bad phosphorylation Bad can inhibit anti-apoptotic signals of Bcl-2 and Bcl- xl, resulting in apoptotic cell death. Phosphorylation of Bad leads its inactivation and inhibition of Bad binding to Bcl-2 and ... can inhibit the apoptotic activity of Bad by activating intra- cellular signaling pathways that results in phosphoryla- tion of Bad (Ser112 and Ser136) [22]. This f...

Ngày tải lên: 11/08/2014, 08:22

... activated by cigarette smoke may activate mast cells (Figure 8). This inference was confirmed by inhibitors of Lyn an d Syk kinases, which are down- stream kinases in FcεRI signaling pathways, and by TGF-b ... results, analysis of the results, writing and input in terms of discussion. DYK - carrying out all BMMCs experiments. EYK - carrying out all animal experiments. GUH -...

Ngày tải lên: 12/08/2014, 13:22

... filter)(Uni- versity of Kentucky, Lexington, KY, USA) for 7 min, 4 times a day. Carboxyhemoglobin-levels in blood were 8.29 ± 1.4% in smoke- exposed vs. 1.02 ± 0.22% in air- exposed mice (n = 7). During air or smoke ... the inflammatory response both in terms of serum IgE and pulmonary inflammation is much less as compared to the inflammatory responses observed after system...

Ngày tải lên: 12/08/2014, 16:20