Báo cáo y học: " Differences in susceptibility to German cockroach frass and its associated proteases in induced allergic inflammation in mice" pot

... AccessResearch Differences in susceptibility to German cockroach frass and its associated proteases in induced allergic inflammation in miceKristen Page*1,3, Kristin M Lierl1, Nancy Herman2 and Marsha Wills-Karp2,3Address: ... purposes)GC frass serine proteases regulate airway inflammation and airway hyperresponsiveness in Balb/c miceFigure 4GC frass serine proteases regulate airway inflammation and airway hyperresponsiveness ... of GC frass associated proteases by using GC frass pretreatedwith aprotinin. There was no effect of removal of GC frass proteases on airway hyperresponsiveness to acetylcholine,TH2 cytokine production,...

Báo cáo y học: " The diagnostic value of serum leptin monitoring and its correlation with tumor necrosis factor-a in critically ill patients: a prospective observational study" ppt

... protein and leucocytosis, suggesting their potential importanceas diagnostic parameters in systemic inflammatoryresponse syndrome (SIRS) and post-surgery sepsis [5].Although cytokines such as interleukin-6 ... admission and leading causes formortality in non-corona ry ICUs [1]. Infections and sep-sis are accompanied by clinical and laboratory signssuch as cha nges in body temperature, leucocytosis, and tachycardia. ... importantcytokine in inflammatory states including sepsis [7].Leptin is an adipocyte secreted hormone. In addition to playing a role in energy regulation, leptin also regu-lates endocrine and immune...

Báo cáo y học: "Impaired vascular responses to parasympathetic nerve stimulation and muscarinic receptor activation in the submandibular gland in nonobese diabetic mice." ppt

... mus-carinic and adrenergic receptors, and are innervated by auto-nomic nerves, we hypothesized that the vascular responses to autonomic stimulation may be reduced in the NOD mice. To test this hypothesis, ... [28]. In autoimmune diseases, vascular cells can actively contribute to the inflammatory cytokine-dependent network in the bloodvessel wall. By interaction with invading cells, the activationmay ... also been demonstrated to have binding affinity to muscarinic receptors, and thereby acts as a muscarinic antag-onist in addition to the ability to inhibit NO synthase [32]. It istherefore possible...

Báo cáo y học: "Validation of actigraphy to assess circadian organization and sleep quality in patients with advanced lung cancer" potx

... of healthyindividuals [11-15]. Care has been taken to fully specifythe instrumentation type, sampling mode and analysistools in order to allow inclusion of this study in thegrowing database ... line to a dataset when searching for a linear increasing or decreasingtrend and subsequently determining the probability thatthe s lope of the best-fitting line is different from zero.Using ... concurrent polysomnography as a reliabletool to objectively measure many standard sleep parameters, as well as daily activity. Actigraphic and subjectivesleep data are in agreement when determining activity-sleep...

Báo cáo Y học: Role of conserved residues within helices IV and VIII of the oxaloacetate decarboxylase b subunit in the energy coupling mechanism of the Na+ pump ppt

... chain oftyrosine 229. This displacement may be facilitated involving by R389 through lowering the pK of the tyrosine hydroxyl group. The proton isdelivered to the carboxybiotin and catalyzes ... serine hydroxyl and anaspartic acid, these experiments argue strongly against anacidic function of the serine hydroxyl; (d) upon replacingserine by alanine the enzyme remains reasonably active ... Simultaneously, the Na+binding ligandsare probably rearranged into a geometry, which is lessfavourable for Na+binding. The binding of Na+ to freeOadB (without carboxybiotin bound) with an afﬁnity...

Báo cáo y học: "Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium" potx

... with ligands, receptors and intracellular signalling pathways playing important roles in determining whether apoptosis occurs. Apoptosis in active RAmay be important as a way of limiting inflammation ... apoptosis-inducing ligand (TRAIL) is a tumour necrosis factor (TNF) familymember capable of inducing apoptosis in many cell types.Methods Using immunohistochemistry, terminaldeoxynucleotidyl ... comprehensivestudy to demonstrate the expression of TRAIL and TRAILreceptors (both death and decoy receptors) in the synovial tis-sue from patients with a range of inflammatory and non-inflam-matory arthritides,...

Báo cáo y học: "The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis" pot

... binding and promoting mRNAdeadenylation [35]. It will be interesting in the comingyears to extend these analyses to other residues in theTZF domain, particularly in the highly conserved inter-finger ... characterized by severe erosive arthritis and inflammatory bowel disease, but inflammation in othertissues was minimal. They also exhibited thymic atrophy and blurring of thymic cortical and medullary boundaries,also ... discovery of its role in regulating TNF-α expression, the years since thatconnection was made have yielded many insights into thefunctions of this fascinating family of proteins. This workby many...

Báo cáo y học: " An open letter to George M Philip, President of the State University of New York At Al" potx

... convinces you, then I’m willing to let you turn your institution into a place that focuses on the practical, but only if you stop calling it a university and yourself the President of one. You ... folly. e faculty in your Italian department would be delighted to introduce you to its many wonders - if only you had an Italian department, which now, of course, you don’t. And do you really ... really think even those faculty and adminis-trators who may applaud your tough-minded stance (partly, I’m sure, in relief that they didn’t get the axe them selves) are still going to be on your...

Báo cáo y học: "Spontaneous rupture of an infected renal cyst and external drainage through a lumbar surgical scar in a male patient with cervical spinal cord injury: a case report" doc

... study ofultrasound examination of urinary tract performed on spinalcord injury patients with no urinary symptoms and spinalcord injury patients with symptoms related to urinary tract:do findings ... abdominalcorset to protect the renal cyst and the surgical scar frompressures applied unintentionally to the lumbar regionduring turning, hoisting and chest physiotherapy.Competing interestsThe ... repeatedminor trauma to his flank during turning, hoisting and chest physiotherapy, which contributed to the rupture ofthe renal cyst. In hindsight, we should have anticipatedthat the renal cyst...

Báo cáo y học: " Diagnostic value of anti-cyclic citrullinated peptides and association with HLA-DRB1 shared epitope alleles in African rheumatoid arthritis patients" ppsx

... sensitiv ity and specificity of anti-CCP2 antibody determinationhave been previously determined in our laboratory in Swiss and in French patients with RA and in controls[13,14]. The sensitivity and ... to the study and an informed consent was obtained fromall patients and controls included in this study.IgM and IgA RF determinations by enzyme immunoassaysCommercially available ELISA kits, purchased ... specificity. ACPA such as anti-cyclic citrullinatedpeptides (anti-CCP) are directed to antigens that containarginyl converted to citrullyl residues by peptidylarginyldeiminase enzymes [4,5]....

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