Báo cáo y học: " The role of IFN-γ in regulation of IFN-γ-inducible protein 10 (IP-10) expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures" potx

... become the major source of IFN-γ in the adaptive immune response [2,3]. IFN-γ- inducible protein 10 (IP -10) is induced by IFN-γ in many types of cells including monocytes and lung epithe- lial cells ... purposes) Respiratory Research Open Access Research The role of IFN-γ in regulation of IFN-γ- inducible protein 10 (IP -10) expression in lung...

Ngày tải lên: 12/08/2014, 15:21

... participates in the inhibition of papain and most likely also of cathepsin L. The side chains of Leu73 and Pro74 jointly contribute  45% of the total unitary free energy of binding of cystatin A to cathepsin ... cathepsin B, demonstrating a major role of the second binding loop of cystatin A in the inhibition of this enzyme. Pro74 may be directly involve...

Ngày tải lên: 17/03/2014, 10:20

... phenylalanine was therefore mutated to Ala, Leu, Trp or Tyr. These mutations may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme ... the enzyme for PAA and derivatives thereof, while maintaining the hydrophobicity of the binding site. To test the effect of the mutations on the specificity...

Ngày tải lên: 17/03/2014, 23:20

... Matthews, R.G. & Penner-Hahn, J.E. (1998) Characterization of the zinc binding site in methionine synthase enzymes of Escherichia coli – the role of zinc in the methylation of homocysteine. ... distinct changes in the zinc ligands. In the His237 fi Ala and Cys239 fi Ala mutants, coenzyme M also seemed to bind efficiently by ligation to zinc indicating that some a...

Ngày tải lên: 17/03/2014, 23:20

... bridge with the carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparently playing a less important role in side-chain binding. Taken together, the results ... these residues in binding the carboxylate linked to the nucleus of penicillin N (Arg160 and Arg162) and the carboxylate of the a-amino- adipoyl side-chain...

Ngày tải lên: 18/03/2014, 01:20

... allergy in a large number of infants[33,34]. There were two major differences between Taylor D s study and the others. The type of probi- otic product was different as well as the timing of the introduction ... strong family history of eczema, allergic rhinitis or asthma, and to their infants for the first six months after delivery. The frequency of developing atop...

Ngày tải lên: 08/08/2014, 21:20

... restoration of prostaglandin synthesis and a normal bone repair process. Another point relates to the use of indomethacin in the inhibition of heterotopic ossification in patients who have sustained ... timeli- ness of the healing. Indeed, the study by Zhang et al. [12] showed that restoration of PGE 2 levels immediately rescues the effects of an absence of COX-2...

Ngày tải lên: 09/08/2014, 01:21

... PHD enzymes in the RA synovium. Therefore, in the future it will important to study the expression and regulation of these enzymes in RA. HIF: role of FIH FIH is an asparaginyl β-hydroxylase, ... evidence for hypoxia in inflammatory and destructive joint disease, and discusses the interplay between alterations in oxygen tension, vascularity and inflammatory...

Ngày tải lên: 09/08/2014, 01:22

... localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells ... page of the manuscript published by Anton Weichselbaum in the Archives for Pathology, Anatomy, Physiology and Clinical Medicine in 1878. (c) Title of the...

Ngày tải lên: 09/08/2014, 01:23

... naturally occurring lovastatin, chemically modified simvastatin and pravastatin [1–3] and the synthetically derived atorvastatin, fluvastatin and cerivastatin. All of these agents are widely used ... bone mass by inhibiting the activity of osteoclasts (the cells responsible for bone loss). The ability of these drugs to increase bone mass is relatively small, certainly no mo...

Ngày tải lên: 09/08/2014, 03:24