... specific strains the reaction can either be mediated by NAT-1 or AANAT, or by both NAT-1 and AANAT. The C57BL/6 mouse strain has undetectable production of melatonin in the pineal gland, and very ... (Shimadzu,Japan). Quantitative determination of N-acetylserotoninwas made by comparing the observed peak areas with the peak areas of known concentrations of the NAS standard.Hydroxyindole-O-methyl-transferase ... Yamazoe, Y., Nishikawa, T. & Kato,R. (1988) Properties of cutaneous acetyltransferase catalyzingN- and O-acetylation of carcinogenic arylamines and N-hydro-xyarylamine. Biochem. Pharmacol....