Báo cáo y học: "Perforin, granzyme B, and FasL expression by peripheral blood T lymphocytes in emphysema" pptx

... T lymphocytes, the lasts having increased cytotoxic activity. Because systemic inflammation is also a component of emphysema, we hypothesize that peripheral CD8 + T lymphocytes of emphysematous ... studies have described their state of activation and their cytotoxic potential in the peripheral blood. Perforin, granzyme B, and FasL are cytotoxic molecules used by CD8...

Ngày tải lên: 12/08/2014, 15:21

... endoscopy in outpatients with iron defi- ciency anemia. The aim of our study was to investi- gate the incidence of GI pathological findings in symptomatic and asymptomatic patients with IDA and to ... 3 Platelets, 4 C reactive protein, 5 Erythrocyte sedimentation rate, 6 Carcinoembryonic antigen 86 patients underwent upper gastrointestinal tract endoscopies and 62 pati...

Ngày tải lên: 25/10/2012, 11:18

... Considering that infiltrating T cells in the rheumatoid synovium in the early stage of RA are predominantly T helper type 1 cells [8], our findings that the degree of lymphoid cell infiltration ... joints by targeted biopsy under arthroscopy, and specimens from long-standing RA were obtained by total knee arthroplasty at the Center for Rheumatic Disease, Matsuyama Red Cross Hosp...

Ngày tải lên: 09/08/2014, 06:23

... assistance in interpretation of the data and draft- ing the manuscript. MR designed the study and provided assistance in analysis and interpretation of the data and draft- ing the manuscript. Acknowledgements This ... therapeu- tic potential in arthritis. Competing interests The authors declare that they have no competing interests. Authors' contributions CB performed the R...

Ngày tải lên: 09/08/2014, 14:21

... a therapeutic option with good outcomes in patients with serious infections with resistant strains of K. pneumoniae, even in neonates and infants. Consent Written informed consent was obtained ... predisposing factors, including prematurity, intravenous catheter, history of antibiotic therapy and intravenous nutrients. Case presentation: A low-birth-weight, 33-day-old Caucasian girl w...

Ngày tải lên: 10/08/2014, 23:21

... proliferations, including intraductal carcinoma, invasive carcinoma, atypical ductal hyperplasia and hyperplasia of the usual type [2-4]. Most invasive carcino- mas that arise in this setting are of the ... epithelial atypia displayed slightly higher proliferative activity. The low proliferative activity in columnar cell lesions noted in this case is compatible with data reported in...

Ngày tải lên: 11/08/2014, 23:21

... - CAGCCTGTTGCCTCTGTGAGA-3 ’ (forward) and 5’ -GGCAGCT CCTTGTTTACTCC-3’ (reverse); and CD70, 5’-GGGCGTCTACTTGCTTCA-3’ (forward) and 5’-CCTGCATCCTGGCAACTGC-3’ (reverse). Real-time quantitative polymerase chain ... CD4 + T cells and healthy controls, con- sistent with the mRNA levels detected by real-time PCR reported in our previous study [21]. Interestingly, our ChIP experiments...

Ngày tải lên: 12/08/2014, 15:22

... antioxidant N-acetyl- L -cysteine (NAC) provides cysteine that feeds into the biosynthetic machinery, allowing the formation of glutathione (GSH) by the action of the rate-limiting enzyme, γ-glutamylcysteine ... pull NF-κB off DNA, and export NF-κB back to its resting state in the cytoplasm. Thick lines indicate the activating pathway; thin lines indicate the inactivating pathway. ....

Ngày tải lên: 12/08/2014, 18:20

... the manufacturer's instructions. The effectiveness of siRNA against specific targets was determined by RPA and immu- noblotting. Competing interests The authors declare that they have no competing interests. Authors' ... eIF5A matura- tion by inhibiting the interaction between DOHH and its substrate, deoxyhypusyl-eIF5A. At clinically used concen- trations, the drugs profound...

Ngày tải lên: 12/08/2014, 23:22

... [42]. Consequently, these microRNAs may contribute to trans- formation of HTLV-1-infected cells, i.e., the pathogenesis of ATLL, by either maintaining differentiation status or actively driving cells towards ... constitutes an important facet in both viruses' efforts to establish perstistence or their potential to bring about malignant transformation. In contrast to activation by...

Ngày tải lên: 13/08/2014, 05:21