Báo cáo y học: " Protective role of vascular endothelial growth factor in endotoxin-induced acute lung injury in mice" potx

... VEGF in the lung induces pulmonary edema with increased lung vascular permeability, the role of VEGF in the development of acute lung injury remains to be determined. Methods: To evaluate the role ... role of VEGF in the pathogenesis of acute lung injury, we first evaluated the effects of exogenous VEGF and VEGF blockade using monoclonal antibody on LPS-...

Ngày tải lên: 12/08/2014, 15:21

... and hydrostatic pulmonary edema may be the dilution caused from the alveolar flooding rather than the degree of lung injury [29]. In the early stage of lung injury different insults and proin- flamatory ... distress syndrome The acute respiratory distress syndrome (ARDS) is the most extreme manifestation of acute lung injury (ALI) [26]. Pulmonary injury in ARDS res...

Ngày tải lên: 12/08/2014, 16:20

... mediator of inflammation and acute lung injury in sepsis [20-22]. This study adds to the previous findings by suggesting that DA may prevent LPS-induced lung injury by inhibiting cytokine and HMGB1 ... treating acute lung injury (ALI), the overall mortality still remains high at approximately 30 to 50% [1]. One of the mechanisms of sep- sis-induced acute lung inju...

Ngày tải lên: 13/08/2014, 08:21

... Porcine surfactant in treatment of LPS-induced early-stage acute lung injury in rats. Chinese journal of pathophysiology 2007, 23:1583-1586. 25. Huang Jing-xia, Sun Yu, Fu Chen-chun, Deng Xiao-ming, ... decreased respiratory rates after acute lung injury was induced with oleic acidPPS administration improved recovery of PaO 2 and decreased respiratory rates after acute...

Ngày tải lên: 13/08/2014, 15:22

Ngày tải lên: 13/08/2014, 21:21

... Seurin D, Segovia-Quinson B, Hardouin S, Binoux M: Analysis of serum insulin-like growth factor binding pro- teins using Western blotting: use of the method for titration of the binding proteins ... Bayne ML, Applebaum J, Chicchi GG, Miller RE, Cascieri MA: The role of tyrosines 24, 31, and 60 in the high affinity binding of insulin-like growth factor- I to the type 1 ins...

Ngày tải lên: 09/08/2014, 01:23

... contribute to joint destruction by secretion of pro-inflammatory cytokines and tissue-degrading enzymes [3]. Recently, microarray techniques employing hybridization of biological samples to immobilized ... TGF-β-signal-transducing smads to the membrane in the close vicinity of the receptor [19] (Figure 1). This interesting finding provides detailed anal- ysis of individual component...

Ngày tải lên: 09/08/2014, 10:20

... negative findings of our study, further intensive studies are needed into strategies for inhibition of cytokine signaling as a way to ameliorat- ing lung toxicity from radiotherapy. Competing interests The ... [14]. Radiation-induced lung injury is a chronic phenomenon mediated by various cells such as inflammatory cells responding to the release or activation of downstream cytoki...

Ngày tải lên: 09/08/2014, 08:23

... forms of ALI in sheep [11,12,16,17]. Employing an ovine model of endotoxin- induced lung injury, our group noticed that intravenously infused APC, at the same dose as used for treatment of severe sepsis, ... Bjertnaes LJ: Combination of intrave- nously infused methylene blue and inhaled nitric oxide amel- iorates endotoxin-induced lung injury in awake sheep. Crit Care Med...

Ngày tải lên: 13/08/2014, 16:20

... glycosylated proteins of about 50–90 kDa. The single polypeptide chain of a kininogen contains three domains resembling family 2 cystatins. Cystatins competitively inhibit the activity of papain- like ... second binding loops of cystatin B and family 2 cystatins and also what residues of this loop in cystatin A may participate in the interaction. To elucidate the role of the...

Ngày tải lên: 17/03/2014, 10:20