Báo cáo y học: " Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery" ppsx

... for citation purposes) Respiratory Research Open Access Research Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery Craig P Hersh* 1,2,3 , Dawn ... randomized to medical therapy. Conclusion: Genetic variants in GSTP1 and EPHX1, two genes encoding xenobiotic metabolizing enzymes, were predictive of response to LVR...

Ngày tải lên: 12/08/2014, 15:21

... utility to predict good to excel- lent response to etanercept therapy (equivalent to response ≥ ACR50 for the ABCoN and Swedish cohorts, and to response ≥ ACR70 for the Japanese cohort), and to predict ... experiments and types of analysisWorkflow of experiments and types of analysis. Upper panel: in the discovery steps, synovial antigen microarrays and multiplex cytokin...

Ngày tải lên: 09/08/2014, 14:21

... today. Many of these enzymes have significant genetic polymorphisms that affect the enzyme s rate kinetics. Regarding drug metabolism, specific polymorphisms to the cytochrome (CYP) P450 enzyme family ... erythrocytes in contrast to the cytochrome P450 enzymes which are located within the hepatocytes. Therefore the phenotype (enzyme activity) can be measured directly. Patients wit...

Ngày tải lên: 13/08/2014, 13:20

... phenotype may give a clue to the right gene or pathway. Recently, we identified the genetic defect in patients with gen- eralized arterial calcification of infancy (MIM#208000) [9]. In addition to ... and 90 years of age. They belonged to 126 two- to four-generation pedigrees. The subjects were uniformly dis- tributed with respect to age between 20 and 70 years. The pedigrees comp...

Ngày tải lên: 09/08/2014, 06:23

... Biogerontology 2002, 3:85-88. 47. Carling T, Ridefelt P, Hellman P, Rastad J, Åkerström G: Vitamin D receptor polymorphisms correlate to parathyroid cell func- tion in primary hyperparathyroidism. ... daily calcium intake. Our results suggest that VDR gene polymorphisms play a role in the etiology of symmetrical hand OA. Moreover, the association between the VDR gene and OA may be m...

Ngày tải lên: 09/08/2014, 07:20

... inhibitor of HO transcription AYR1 YIL124W NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase CYT1 YOR065W Cytochrome c1, component of the mitochondrial respiratory chain FYV10 YIL097W ... lacking telomerase are likely to be due to a number of factors. Firstly, different genes may be altered due to responses to distinct types of telomere damage. Secondly, in a population of c...

Ngày tải lên: 14/08/2014, 21:20

... infiltration has a key role in the pathogenesis of chronic arthritis [8]. The release of pro- inflammatory cytokines, chemokines, growth factors, and enzymes by the synovial lining macrophages is important for ... of a cytoskeletal component that might be released during leukocyte influx into inflammatory tissue. Further, mactinin might have a role in promoting the response of mononuclear p...

Ngày tải lên: 09/08/2014, 01:23

... laboratory signs of inflammation may be caused not only by infection, but also by tissue injury and mainly by the systemic inflammatory response syndrome (SIRS) associated with cardiopulmonary bypass ... cardiopulmonary bypass, cardiac operations, open heart surgery, coronary artery bypass grafting, post-cardiac surgery infections, ICU infections, ICU-flora, MRSA 6 postoperatively...

Ngày tải lên: 10/08/2014, 09:22

... Antibodies to ATS (anti-PL-12) represent the most common reactivity that defines the antisynthetase syndrome, which is typically expressed as polymyositis, dermatomyositis and interstitial lung disease ... autoanti- body reactive to cytokeratin 8 was defined by western immunoblotting and by enzyme- linked immunosorbent assay [5]. Similar data support a role for antibodies that are reac...

Ngày tải lên: 12/08/2014, 18:20

... cytoskeletal plasticity. The cytoskeleton of ASM is con- tinuously adapting to its dynamic microenvironment, and these cytoskeletal-remodeling events seem to play out over a wide range of time ... fails to respond to a DI, it must take a relatively long time to attain that frozen contractile state [4]. The issue of time also comes into play with considerations of cytoskeletal plasti...

Ngày tải lên: 12/08/2014, 18:20