Báo cáo y học: "Efficacy and safety of tiotropium in COPD patients in primary care – the SPiRiva Usual CarE (SPRUCE) study" ppsx

... purposes) Respiratory Research Open Access Research Efficacy and safety of tiotropium in COPD patients in primary care – the SPiRiva Usual CarE (SPRUCE) study Daryl Freeman* 1 , Angela Lee 2 and David ... under-diagnosed and the role of primary care is critical to early and correct diagnosis, since a large proportion of smokers with early s...

Ngày tải lên: 12/08/2014, 15:20

... (dehydro- genation, hydroxylation, and N-dealkylation), mainly by cytochrome P450 2D6 (CYP2D6) and cytochrome P450 3A4 (CYP3A4) [60]. The parenteral drug is excreted only in traces. There is only ... by 142 (76%) of the 186 patients in the placebo group and 154 (87%) of the 178 patients in the aripiprazole group. The most frequent adverse events (≥5% incidence...

Ngày tải lên: 08/08/2014, 23:21

... spray (black squares) and Placebo (black triangles) treatment groups. The y axis shows the day of recording. The y axis shows the study day; i indicates the point of inclusion into the study. Eccles ... efficacy analysis of symptoms. In total, 14 Iota-Carrageenan patients and 18 placebo patients were eligible for analysis of symptoms. The predefined primar...

Ngày tải lên: 12/08/2014, 11:22

... III st udies, ACCLAIM /COPD (AClidinium CLinical trial Assessing efficacy and safety In Moderate to severe COPD patients) I and II, to assess the long-term efficacy and safety of * Correspondence: ... of dry mouth, urinary retention and arrhyth- mias [24, 25]. In the ACCL AIM /COPD studies, the inci- dence of anticholinergic AEs was similar between the two...

Ngày tải lên: 12/08/2014, 13:22

... for clinicians to understand. The aim of our study was to systematically review the evidence in order to answer key clinical questions about the efficacy and safety of CPAP and NPPV in the treatment ... related to the extreme findings of 55% risk reduction for both ETI and mor- tality in the study by Takeda and colleagues [12]. Only three studies included dat...

Ngày tải lên: 12/08/2014, 23:23

... 12:R117 http://arthritis-research.com/content/12/3/R117 Page 11 of 11 Recombinant Infliximab Therapy Study Group: Efficacy and safety of infliximab in patients with ankylosing spondylitis: results of a randomized, placebo-controlled ... studies, we investigated the effectiveness and safety of adalimumab in treating patients with active AS or PsA who had a history...

Ngày tải lên: 12/08/2014, 14:22

... over-distension and cyclic inflation and deflation of alveoli can damage the alveolar–capillary barrier and initiate or amplify a local and systemic inflammation, so the concept of ventilator-induced lung injury ... No changes in ventilatory setting were made during the treatment. A bolus of 2,000 UI of heparin was administered intravenously, followed by an infusion ti...

Ngày tải lên: 13/08/2014, 03:20

... not likely explain the immediate relief of dyspnea reported by many patients. Alternatively, draining pleural effusions may reduce the work of breathing by impr oving the mechanics of the diaphragm. ... (as defined in each study), and the remaining 3 % had inde- terminate biochemical findings. Methodological quality There were no randomized or non-randomized con- trolled...

Ngày tải lên: 14/08/2014, 07:21

... tissues We investigated JAM-C expression in human OA and RA syn- ovial samples by IHC using polyclonal antibodies against human JAM-C. Interestingly, expression of JAM-C was mainly found in the lining ... similar to that found in human arthritic tissues. Expression of the protein was mainly found in the lining layer and was associated with vessels in the sublining la...

Ngày tải lên: 09/08/2014, 10:20

... high-affinity binding site for a G-protein in its GDP-bound inactive state. The receptor spe- cifically interacts with the C-terminus of the α subunit of the G-protein heterotrimer. G-protein binding ... JM and Hoffman BB Isoform-specific sensitization of adenylyl cyclase activity by prior activation of inhibitory re- ceptors: role of beta gamma subunits in transducing...

Ngày tải lên: 13/08/2014, 13:20