Báo cáo y học: "Control of mucosal virus infection by influenza nucleoprotein-specific CD8+ cytotoxic T lymphocytes" ppsx

... cell cytotoxicity against cytopathic viruses such as influenza remains controver- sial. Some studies have suggested that cytokines released by T cells and neutralizing antibodies constitute the ... reduce lung virus titers and mortality but the CTLs were directed to a single NP epitope and were probably inadequate to protect against a lethal influenza challenge. The role of contac...

Ngày tải lên: 12/08/2014, 15:20

... Micro-otoscopy showed left purulent otorrhea through a central perforation of the tympanic membrane. As symptoms persisted despite antibiotic therapy (mer- openem trihydrate 1 g twice/day and clindamycin ... was located mainly between the levels of the base of the skull and soft palate medial to the great vessels, and did not involve multiple spaces, and the patient did not have any air...

Ngày tải lên: 11/08/2014, 17:21

... TTG TT G GTG CAC TCG AGT CAA CGT GCA CCA ACA ATC TAT GTC T TC CCT TTT TG-3'; siDEN3UT:5'- GGA AAA ACA GCA TAT TGA CGC TGC TCG AGT CAA CGC AGC GTC AAT ATG CTG TTT TTC CCT TTT TG-3'. Each ... GGT GGC ATC GCC CTT TTT G-3' [10]; siRSVNS1:5'-GGC AGC AAT TCA TTG AGT ATG CTT CTC GAA ATA AGC ATA CTC AAT GAA TTG CTG CCT TTT TG-3'; siDENPrM: 5'-GGA AGA CAT AGA TTG T...

Ngày tải lên: 14/08/2014, 19:22

... senses the energy state of the cell and becomes activated under metabolic stress, inactivates by phosphorylation key enzymes in biosyn- thetic pathways thereby conserving ATP. In this paper, we studied ... likely to be activated by the amino-acid-induced accu- mulation of glutamate and is inhibited by calyculin A [17]. Activation of AMPK inactivates ACC by direct phospho- rylati...

Ngày tải lên: 22/02/2014, 07:20

... byproduct of urate oxidation [23]. Either directly or through the generation of H 2 O 2 , extensive deposits of urate crystals in tissues of humans with inadequately treated gout might act as a potent ... A, Yamanaka H, Kamatani N: A retrospective study of the relationship between serum urate level and recurrent attacks of gouty arthritis: evidence for reduction of recurrent gou...

Ngày tải lên: 09/08/2014, 07:20

... median time to re-starting treatment was 4.5 months. Sixty-eight patients remained off treatment for at least 6 months. By that time all but 2 patients (the SC) had a VL that exceeded 3log. Both ... cessation. Skiest et al mentioned 2 patient s who had an undetectable viral load for 6 months after treatment was stopped as part of a study on the effects of treatment interruption. However...

Ngày tải lên: 10/08/2014, 05:22

... indicated by the dark grey bars. The initiation (arrow #2) and duration of administration of recombinant activated factor VII is indicated by a light grey bar, while the duration of unfractionated ... education class (with the limitation of contact sports), ambulating, and r eceiving physical therapy. Discussion The case presented demonstrates several important points regarding th...

Ngày tải lên: 11/08/2014, 12:20

... ratio of heterologous titer obtained with virus 2 to homologous titer obtained with virus 1; r2 is the ratio of the heterologous titer obtained with virus 1 to homologous titer obtained with virus ... such mutation on the antigenicity of H3N2 TR viruses. To have a better interpretation of the a bove observa- tions, we translated the HI-cross reactivity results to “percent anti...

Ngày tải lên: 12/08/2014, 01:22

... STAT2 that is phosphorylated on Tyr 690 . Phosphorylated STAT2 protein then associates with STAT2, inducing its phosphorylation on Tyr701 by JAK1 [2,3]. S TAT1 and STAT2 form a heterodimer that creates ... associated with preservation of wild-type phe- notype in the V protein (VWT) of HN-A1081 Virus var- iant. In the present study we experimentally tested the interaction of VWT and...

Ngày tải lên: 12/08/2014, 01:22

... phylogenetic tree analysis of DENV-3 genotype III strains isolated in Vene zuela.Strainsinthetreesare shown by the standardized terminology (which identifies their serotype, country, name and year ... of the present study was to gain insight into the degree of g enetic variability, rates and patterns of evolution of this genotype in Venezuela and the South American region based on...

Ngày tải lên: 12/08/2014, 02:20