Báo cáo y học: "A novel human ex vivo model for the analysis of molecular events during lung cancer chemotherapy" pptx

... of the patients. The purpose of the present study was the development of a human ex vivo tissue culture model and the analysis of the effects of conventional chemotherapy, which then can serve ... the individual trend of response. BioMed Central Page 1 of 11 (page number not for citation purposes) Respiratory Research Open Access Research A novel hu...

Ngày tải lên: 12/08/2014, 15:20

... removed for analysis of IFN-γ production by ELISA after 2 days. These cells were then cultured for a further 10 days in the presence of IL-2, following which they were re- stimulated either with the ... activation of lym- phocytes must be dependent upon the uptake of the pep- tide by iDCs and its representation to lymphocytes and (b) it is not the result of any adjuv...

Ngày tải lên: 11/08/2014, 10:23

... monomeric size of these hydratase/aldolase enzymes. All of these enzymes exhibit more then 75% of their maximum activity at pH 7.6, the optimum pH of citral lyase [27,30–32]. Whereas, many bacterial ... change during induction. Stability of citral lyase activity The activity and stability of citral lyase was dramatically affected by the addition of 20% (v/v) glycerol and...

Ngày tải lên: 21/02/2014, 01:21

... were retained for further analysis. Additional file 22 shows the raw data of the proteomic analysis by 2DGE following the overexpression of Runx1. The detailed spot quantifica- tion data, in the form of ... cells and the non-induced state (in the cases of Bach1 and Gabpa, for example) was not statistically significant and therefore can be explained by the biolog...

Ngày tải lên: 09/08/2014, 20:22

... modeling The SWISS - PDB VIEWER software from the EXPASY server (http://www.expasy.ch) was used to visualize and compare the effect of the substitution of a glutamic acid for a glycine on the structure ... Hammock 1 1 Department of Entomology and Cancer Research Center, 2 Section of Neurobiology, Physiology and Behavior, and 3 Department of Chemistry and Superfund Anal...

Ngày tải lên: 31/03/2014, 08:20

... for the analysis and display of circadian activity data. Activity Profile plots the average activity for specified dates as a function of cir- cadian time. We grouped activity events into thirty ... calculated the mean activity during the last eight days under LD 12:12. We assessed the phase of minimum activity during the dark part of the cycle. Calculating c...

Ngày tải lên: 10/08/2014, 09:20

... azaheterocycles [8] are some of the synthetic applications of oximes. They are also useful for selective a-activat ion [9] and are extensively used as intermediates for the preparation of amides by the ... industry deals with larger quantity of materials, these factors are particularly very important therein. Over the years, many reagents and catalysts have been developed...

Ngày tải lên: 20/06/2014, 22:20

... Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Department of Laboratory Medicine, Chong- qing Medical University, Chongqing 400016, China 2. Center for Hematology, ... [3, 4]. The most common molecular variant of the NPM1 gene is mutation A, accounting for about 75-85% of cases. It is due to a duplication of TCTG tetranucleotide at the C-t...

Ngày tải lên: 08/08/2014, 18:21

... It is, therefore, possible that changes such as these to recep- tor expression, signalling pathways and to the biosynthe- sis of cytokines, which normally occur during the maturation of monocytes ... (acetylsalicylic acid) was first synthesized in 1899 and was the first example of the family of nonsteroidal anti-inflammatory drugs (NSAIDs). Its therapeutic uses include the...

Ngày tải lên: 11/08/2014, 08:22

... K, Xu N, Zhen Y, Boniface JJ: An integrated strategy for the discovery of drug targets by the analysis of protein-protein interactions. International Journal of Mass Spectrometry 2004, 238:119-130. doi:10.1186/1465-9921-12-8 Cite ... 0.5% w/v cyclodextrin as a vehicle for the delivery of small molecules. Among the seven scaffolds which showed activity in the FP assay...

Ngày tải lên: 12/08/2014, 13:22