Báo cáo y học: " Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitis" pot

... of 13 (page number not for citation purposes) Respiratory Research Open Access Research Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for ... of human lung fibroblasts to V 2 O 5 resulted in significantly altered expression of over 1400 genes on the Affymetrix Human Genome U133A 2.0 Array...

Ngày tải lên: 12/08/2014, 15:20

... and this appeared to be related to decreased lev- els of Tax 2A expression [12]. The aims of the present study were firstly, to examine the ability of different Tax 2A proteins to transactivate ... activation of both CREB and NFkB pathways by Mo [19]. Ability of Tax 2A mutants to transactivate the HTLV-1 LTR and NFkB promoters Initially site directed mutagenesis was used...

Ngày tải lên: 13/08/2014, 09:21

... gene product. Ingenuity pathway analysis of a network of genes expressed in EB and BC data sets associated with GATA2Figure 6 Ingenuity pathway analysis of a network of genes expressed in EB ... Biology 2007, 8:R240 Ingenuity pathway analysis identified a network of genes expressed in EB and BC data sets associated with VEGFFigure 5 Ingenuity pathway analysis identifi...

Ngày tải lên: 14/08/2014, 08:20

... luciferase activity of the promoter constructs divided by the sea-pansy luciferase activity, for each of the three replicates that were done for each of the three clones for humans and chimpanzees ... measured with Affymetrix U95A arrays from livers and the prefrontal cortex of the brains of three humans and three chimpanzees [6] were used to identify genes that differ s...

Ngày tải lên: 14/08/2014, 14:21

... We Significantly differentially regulated pathways identified by GSEA analysisFigure 1 Significantly differentially regulated pathways identified by GSEA analysis. The histogram represents the frequency distribution ... restricted to the genes that had been assigned to gene sets in the starting databases such as KEGG. To identify novel genes that may belong to the same aggregat...

Ngày tải lên: 14/08/2014, 14:21

... valuable approach for identifying the in vivo binding sites of transcription factors [1-6]. Before the availability of complete genome sequence the use of this approach for identifying transcription ... past few years, a number of laboratories have successfully used high-density DNA microarrays to identify sequences enriched by chromatin immunopurification (the ChIP-array appr...

Ngày tải lên: 14/08/2014, 14:21

... pooled datasets. Both synonymous and nonsynonymous sites were examined for the coding regions of each gene. Additionally, because regulatory elements are often found in first introns, levels of polymorphism ... is less opportunity for information content in UTRs and introns in sex-specific genes. To explicitly test the hypothesis that UTRs of sex-specific genes have fewer regul...

Ngày tải lên: 14/08/2014, 20:22

... chart of hEx1 library analysisFigure 1 Flow chart of hEx1 library analysis. Original library of 193,536 clones 37,830 clones selected for protein expression using anti-RGS His antibody Normalization ... cerevisiae as a system for expression of human proteins on a proteome- scale. J Struct Funct Genomics 2003, 4:97-108. 8. Kigawa T, Yabuki T, Yoshida Y, Tsutsui M, Ito Y, Shib...

Ngày tải lên: 14/08/2014, 14:21

... ains. Gene ontology (GO) enrichment analysis using DAVID of the human list of differentially expressed genes returned 879 signifi- cant GO terms, of which 6 terms pertain directly to the lung development. ... We therefore hypothesized that genes influencing normal airways development, especially during the branching morphogenesis stage of human lung development, would...

Ngày tải lên: 12/08/2014, 13:22

... Biology 2007, 8:R127 of all TEs. A goodness -of- fit χ 2 test was used to asses the exonization fraction in every section of the gene. Statistical analysis For the comparative analysis of exonization ... therapeutic implications in cancer biology. Oncogene 2006, 25:1125-1142. 55. Wang CY, Liang YJ, Lin YS, Shih HM, Jou YS, Yu WC: YY1AP, a novel co-activator of YY1. J Biol Che...

Ngày tải lên: 14/08/2014, 07:21