Báo cáo y học: "Synovial effusion and synovial fluid biomarkers in psoriatic arthritis to assess intraarticular tumor necrosis factor-a blockade in the knee joint" doc

... 8 RESEARC H ARTIC LE Open Access Synovial effusion and synovial fluid biomarkers in psoriatic arthritis to assess intraarticular tumor necrosis factor-a blockade in the knee joint Ugo Fiocco 1* , Paolo ... of synovial effusion (SE), synovial fluid (SF) and synovial tissue (ST) biomarkers in relation to disease activity indexes to asse...

Ngày tải lên: 12/08/2014, 14:22

... N., Ikeshiro, Y. , Kushiro, T., Shibuya, M. & Ebizuka, Y. (2001) Cloning and characterization of a cDNA encoding b-amyrin synthase involved in glycyrrhizin and soyasaponin biosynthesis in licorice. ... useful tool not only for elucidating bryonolic acid biosynthesis in cultured Luffa cells, but also for studying the regulation of the branch point in triterpenoid biosynth...

Ngày tải lên: 08/03/2014, 23:20

... N-(2-(4-(2,2-dimethylpropionyloxy)phenylsulfonylamino)benzoyl) aminoacetic acid N-(o-(p-pivaloyloxybenzene)sulfonylamino benzoyl)glycine (Calbiochem) IC 50 = 50 nM [39] Respiratory Research 2009, ... neutrophils and likely results from hydrolysis of collagen [22]. Injection of N-α-PGP into normal corneas recapitulated the neutrophilic inflamma- tion seen in alkali injury to the eye...

Ngày tải lên: 12/08/2014, 14:20

... Holly JMP: Changes in the local regulation of insulin-like growth factors I and II and insulin-like growth factor-binding proteins in osteoarthritis of the canine stifle joint secondary to cruciate ... 39:968-978. 26. Morales TI: The insulin-like growth factor binding proteins in uncultured human cartilage. Increases in insulin-like growth factor binding protein 3 during o...

Ngày tải lên: 09/08/2014, 01:23

... 2a). To investigate the fine specificity of the T cells and to deter- mine whether their TCRs bind to the same or different resi- dues, we synthesized a panel of naturally occurring peptides and ... the initiation of the study. They greatly acknowledge the expert assistance of Franck Lager for breeding and husbandry of the mice, and the collaboration of the st...

Ngày tải lên: 09/08/2014, 10:21

... based on observations of increased levels of the pro-inflammatory cytokines tumor necrosis factor alpha (TNFα) and interleukin-1 beta (IL-1β) in cerebrospinal fluid and brain cortex of AD patients ... NOS enzymatic activity In order to determine whether the enzymatic activity of iNOS may play a role in sustaining TNFα/NGF-promoted signaling we pretreated PC12 cells with...

Ngày tải lên: 19/06/2014, 22:20

... inflammatory mediators and matrix metalloproteinase activity in inflamed jointsSynovial fluid inflammatory mediators and matrix metalloproteinase activity in inflamed joints. Synovial fluid (SF) levels ... due to each individual mediator. The observed increases in these mediators, how- ever, do implicate each of them in the synovial inflammatory process, and they a...

Ngày tải lên: 09/08/2014, 13:22

... [13]. There is increasing evidence that SFs are key players in the pathogenesis of RA by invading and eroding hyaline cartilage. SFs, activated locally, produce a variety of cytokines, chemok- ines ... regulated by inflammatory cytokines. We found a robust gene expression of the glycosidase-like Hc-gp 39 in the SMs, and in particular in SFs, of both RA and OA patients. Th...

Ngày tải lên: 09/08/2014, 14:20

... Many researchers address the ability to proliferate, the induction of apoptosis and the cytokine expression by these experiments. The intention of the paper is not to recommend excluding culturing RASF ... with physiologic matrix remodeling is therefore mandatory to identify novel therapeutic targets to inhibit the progressive joint destruction by RASF. Several cytogenet...

Ngày tải lên: 12/08/2014, 12:20

... HS: Interleukin- 1beta-stimulated invasion of articular cartilage by rheumatoid synovial fibroblasts is inhibited by antibodies to specific inte- grin receptors and by collagenase inhibitors. Arthritis ... Nevertheless, these data highlight the role played by PTP-α as a key upstream regula- tor of integrin-mediated signalling, linking ECM signals to cell migration and Src-FAK si...

Ngày tải lên: 09/08/2014, 01:22