Báo cáo y học: "TAM receptor ligands in lupus: Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus " ppsx

... of systemic lupus erythematosus; APS, antiphospholipid syndrome; BILAG, British Isles Lupus Assessment Group; F, female; M, male; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index. Suh ... 2010. doi:10.1186/ar3088 Cite this article as: Suh et al.: TAM receptor ligands in lupus: Protein S but not Gas6 levels reflect disease activity in s...

Ngày tải lên: 12/08/2014, 14:22

... relapse. Discussion Disease activity in RA patients was found to correlate strongly with K 2P 5.1 expression levels in CD4 + Tlym- phocytes in the peripheral blood in a cross-sectional study in 58 patients. ... ade- quately to first-line therapy. In these cases, as well as in patients with disease exacerbations, a change in treat- ment strategy is required [2]. Monitor...

Ngày tải lên: 12/08/2014, 15:22

... hypertrophy, and mononuclear cell predominance within synovial tissue [7]. The injection of rHMGB1 results in mild to moderate synovitis and may persist for at least 28 days. The induction of arthritis ... statistically insignificant. HMGB1 mRNA expression remained unchanged after infliximab therapy as indicated by only two of the six patients studied by RT- PCR having decreased HMGB1 mRNA...

Ngày tải lên: 09/08/2014, 10:23

... radiographs but the increased SP-D seen in AIDS patients in this study is consistent with recent observations made of intensive Table 1: Demographic and clinical features of subjects in the study Clinical ... altered by HIV status or clinical AIDS. Previous studies have shown that SP-D deficiency is asso- ciated with increased respiratory infection[7] and is asso- ciated with increase...

Ngày tải lên: 12/08/2014, 15:20

... phosphorolysis catalyzed by HIV-1 reverse transcriptase is responsible for the synergy found in combinations of 3'-azido-3'-deoxythymidine with nonnucleo- side inhibitors. Biochemistry ... ratios based on the single drug IC 50 values for cell-based combination assays. For HIV-1 RT enzymatic assays, two drug combina- tions were tested using three series of experiments with increas...

Ngày tải lên: 12/08/2014, 23:21

... 3-phosphoglycerate into 3-phosphoserine during the first two steps of serine biosynthesis. SerC can also catalyze a related step in pyridoxal 5'-phosphate (PLP) bio- synthesis involving a similar substrate. ... CLUSTALW [45] to clarify the specific func- tions of some genes assigned to ambiguous COGs. In- line probing assays RNA preparation, radiolabeling, and in- line probing assays...

Ngày tải lên: 14/08/2014, 14:22

... and a cytoplasmic part that is devoid of any intrinsic enzymatic activity but constitutively associates with tyrosine kinases of the Janus kinase (Jak) family. Upon ligand binding the associated ... Jaks become activated by transphosphorylation and phosphorylate tyrosine residues in the cytoplasmic part of the receptor. These phosphotyrosines serve as docking sites for signalling molec...

Ngày tải lên: 18/03/2014, 01:20

... chains that contain varying numbers of immunoreceptor tyrosine-based activating motifs (ITAMs). The dual tyrosines of ITAMs are phosphorylated by the Src family kinases (SFKs), which, in T cells, ... T-cell receptor signaling are both associated with distinct inflammatory diseases in mice. Mechanisms by which these pathways contribute to disease in mouse models and patients are unde...

Ngày tải lên: 09/08/2014, 01:22

... SLE and lupus- like syndrome in myeloproliferative disease was induced by treatment with IFN-γ [42,43]. Similar to the findings of the present study, in sarcoidosis, a disease characterized by ... syndrome resembling systemic lupus erythematosus (SLE) [1]. The natural history of diffuse pul- monary involvement seen in MRL/lpr mice as well as SLE patients has not been clearl...

Ngày tải lên: 09/08/2014, 01:23

... determined using standard χ 2 tests. We used the EH program [23] to inves- tigate the relative risks associated with haplotypes. P < 0.05 was considered statistically significant. Results Distribution ... the same sex. Estrogen receptor- α gene polymorphisms and risk for late onset osteoarthritis Late onset OA patients were defined as those with disease onset at age above 52 years, wh...

Ngày tải lên: 09/08/2014, 01:23