Báo cáo y học: "Efficacy assessed in follow-ups of clinical trials: methodological conundrum" docx
Báo cáo y học: "Efficacy assessed in follow-ups of clinical trials: methodological conundrum" docx
... early aggressive therapy with combinations of
conventional disease-modifying antirheumatic drugs
including corticosteroids pays off in terms of long-term
radiographic and clinical benefi ts is credible. ... confounding by indication. I think in RA, with its
many eff ective treatments to choose and its inextricable
relationship between disease activity (determinant) and
Abstract
I...
Báo cáo y học: " Efficacy, safety and pharmacokinetic of once-daily boosted saquinavir (1500/100 mg) together with 2 nucleos(t)ide reverse transcriptase inhibitors in real life: a multicentre prospective study" ppt
... presence of more adherent patients in the
“simplification ” group may be the cause of the hig her
efficacy observed in these patients. Although the efficacy
of a once daily dosing of SQV/r has mainly ... formulation yet.
Methods: Prospective, multicentre study in which efficacy, safety and pharmacokinetics of a regimen of once-daily
SQVr 1500/100 mg plus 2 NRTIs wer e evalua...
Báo cáo y học: " Efficacy and hypnotic effects of melatonin in shift-work nurses: double-blind, placebo-controlled crossover trial" ppt
... melatonin in
patients with insomnia than in healthy controls, and
Haimov et al [31] found lower levels of urinary 6-sulpha-
toxymelatonin in elderly patients with insomnia than in
healthy elderly ... melatonin effect on different kinds of
insomnia parameters (difficulty falling asleep, difficulty
staying asleep, problem waking up too early, and sleep
quality) causing by shift work...
Báo cáo y học: " Efficacy, safety and tolerability of escitalopram in doses up to 50 mg in Major Depressive Disorder (MDD): an open-label, pilot study" doc
... limited in future trials, possibly by improving patient
awareness of the transient nature of some side effects
including worsening of depression/anxiety/low mood on
changing to a low dose of another ... al: Differences in the dynamics of serotonin reuptake
transporter occupancy may explain superior clinical efficacy of
escitalopram versus citalopram. Int Clin Psychopharmacol...
Báo cáo y học: "Somatic mutations in mitochondria: the chicken or the egg" docx
... mito-
chondrial syndromes like Leigh syndrome or Leber’s hereditary
optic neuropathy are caused by inherited (germline)
mutations of mtDNA. They comprise a wide spectrum of
clinical symptoms that ... a result of dysfunction of the
mitochondrial respiratory chain, mostly affecting tissues that
are highly dependent on oxidative metabolism such as the
nervous system or the eye [2]. In...
Báo cáo y học: "Increased lymphangiogenesis in joints of mice with inflammatory arthritis" pptx
... composed of various cell types that produce a vast
array of inflammatory mediators, including cytokines and
chemokines that destroy the extracellular matrix in the joint by
direct and indirect ... The
lymphatic system may play an important role in the pathogenesis
of inflammatory arthritis.
Introduction
Joint disease in rheumatoid arthritis (RA) is characterized by
inflamed hyperp...
Báo cáo y học: " What have we learned from clinical trials in primary Sjögren’s syndrome about pathogenesis" ppsx
... type 1 interferon bioactivity, demonstrated by
their capacity to induce expression of type 1 interferon-
regulated genes in a monocytic cell line, whereas
monocytes of pSS patients showed increased ... of blocking TNFα in pSS [20]. e role
of IFNα is discussed in the next section.
IFNα in primary Sjögren’s syndrome: a double-
edged sword?
ere is increasing interest in t...
Báo cáo y học: "Variability science in intensive care – how relevant is it" docx
... variability decreases. Even low-frequency
variability in heart rate – a parameter that traditionally was
considered a marker of sympathetic activity in conditions of
Commentary
Variability science in intensive ... application in the critically ill.
The investigator must always verify the data before
computing the variability estimates. Nonstationarities in the
signals confound t...
Báo cáo y học: "Chiropractic manipulation in Adolescent Idiopathic Scoliosis: a pilot study" docx
... satisfactory distribu-
tion of scores. SQLI has five domains: physical activity
performance (the presence and extent of physical limita-
tions); back pain (the intensity and frequency of back
pain); ... used and
intra- and inter-examiner reliability was measured using
two independent orthopedic surgeons blinded to treat-
ment allocation.
Because there is a clinically important increase...
Báo cáo y học: "Postural development in school children: a cross-sectional study" docx
... measurement
of clinical reliability and validity. J Orthop Sports Phys Ther 1994,
20(4):193-199.
19. Dunk NM, Chung YY, Compton DS, Callaghan JP: The reliability of
quantifying upright standing postures ... physical
therapy clinics. It is possible that some of these patients
will develop a spinal disorder in older age and only a lon-
gitudinal study can identify this to be correct o...
Từ khóa: