Báo cáo y học: "Gene expression profiling in circulating endothelial cells from systemic sclerosis patients shows an altered control of apoptosis and angiogenesis that is modified by iloprost infusion" potx

... expression profiling in circulating endothelial cells from systemic sclerosis patients shows an altered control of apoptosis and angiogenesis that is modified by iloprost infusion. Arthritis Research ... cells from systemic sclerosis patients shows an altered control of apoptosis and angiogenesis that is modified b...

Ngày tải lên: 12/08/2014, 14:22

... experimental processes and in the finalization of the manuscript. EGB controlled Affymetrix hybridization and scanning experiments, managed preliminary data analysis and finalized the manuscript. TTG designed ... interpretation of data in gene expression stud- ies. Animal models of RA can facilitate the interpretation of genome-wide gene expression by providing genetic...

Ngày tải lên: 09/08/2014, 06:22

... and immunohistochemistry experiments and by linking our data to potential mechanisms of resistance to TNF blockade in RA. Our findings about the changes induced by adalimumab in synovial tissue between T0 and ... any rel- evant pathway. It should be stressed in that perspective that RA is not a systemic disease. The inflammatory mechanisms targeted by TNF-blocking...

Ngày tải lên: 09/08/2014, 14:20

... genes included potential key candidates in the regulation by TGFβ of lung tissue fibrosis and included angiotensin II receptor type 1 (AGTR1), SMURF2, a gene involved in terminating TGFβ signalling, ... the accessory receptor betaglycan, a membrane anchored proteoglycan which increases the affinity between TGFβ and type I and II receptors. Interestingly, TGFβ upregulated activin...

Ngày tải lên: 12/08/2014, 18:21

... They also Number of genes regulated by Hfe disruption by mouse strain and organ studiedFigure 1 Number of genes regulated by Hfe disruption by mouse strain and organ studied. Genes regulated by ... has not yet been observed and is inter- esting within the context of recent reports indicating that Zip4 is a minor intestinal iron importer [26] and that Zip14 med...

Ngày tải lên: 14/08/2014, 08:20

... inflam- matory disease of unknown aetiology that is characterized by infiltration of monocytes, T cells and polymorphonuclear cells into the synovial joints. The pathogenesis of this dis- ease is still ... this model, a synovitis with maximal swelling at 24 hours is induced by local injection of SCW antigen directly into an ankle joint. The initial response is re...

Ngày tải lên: 09/08/2014, 06:22

... helped in collecting and processing tissue samples, and advised running and inter- preting low-density arrays. CJP and XSP designed the low- density arrays. CD and AC took patient consent and coordi- nated ... demonstrate that assigning relative importance to any gene in distinguishing OA from NOF is not trivial. Unsupervised cluster analysis shows that the samples a...

Ngày tải lên: 09/08/2014, 14:22

... BCL2L1, and CREBBP genes in primary T-ALL samples blocks apoptosis in malignant T cells [15]. This study suggests that inhibition of BCL11B may trigger apoptosis in leukemic T cells by downregulating ... downre- gulation of CREBBP was identified in the microarray analysis, but not confirmed by real-time PCR analysis. The reason may be due to a systemic error on t...

Ngày tải lên: 10/08/2014, 21:23

... setup and analysis of Eutypa lata exper- iment. SP and CM were involved in validation grapevine MapMan for Affymterix microarrays. KG was involved in organization of the work and writing of the manuscript. Additional ... UV-scavengers and are involved in disease resistance [13]. In red grape, flavanols and anthocyanins are the most abundant flavonoid classes, the latte...

Ngày tải lên: 12/08/2014, 03:21

... genes in the eight trisomic and control mice. Variation of gene expression in the brains of Ts65Dn and control mice Analysis of individual samples allows recovery of important information that cannot ... directly, and to the best of our knowledge this is the first report dealing with this impor- tant issue, an appreciation of which is essential to our under...

Ngày tải lên: 14/08/2014, 07:21