Báo cáo y học: "New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model" potx

... reproduction in any medium, provided the original work is properly cited. Research article New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression ... subcutane- ously into 24 Wistar Kyoto rats (12 males and 12 females rats) at the age of five weeks. Each pellet was implanted beneath the skin...

Ngày tải lên: 12/08/2014, 14:22

... will interrupt the protein C pathway [20] and stimulate the tissue factor pathway [21], both of which may lead to an increase in the risk of coagulation and disseminated intravascular coagulation ... chain and four on the heavy chain, showed a heterogeneous pattern, with a combination of variable terminal fucosylation and sialylation on multiantennary complex-type sugars....

Ngày tải lên: 07/03/2014, 06:20

... data are lacking. In the present study, we have used a continuous fluorescence assay with different rhodamine analogues to quantify their transport by P-gp in intact cells. The rate of dye transport was ... 2003 New insights into the P-glycoprotein-mediated effluxes of rhodamines Chatchanok Loetchutinat, Chantarawan Saengkhae, Carole Marbeuf-Gueye and Arlette Garnier-Suiller...

Ngày tải lên: 08/03/2014, 08:20

... algorithms (including the LMS) can be seen as approximations of the RLS. Therefore, there is always a need to interpret and understand in new ways the different variables that are built in the RLS algorithm. The ... is not as widely used in prac- tice as the least mean square (LMS), it has a very significant theoretical interest since it belongs to the Kalman filters fa...

Ngày tải lên: 23/06/2014, 01:20

... is in striking contrast to the multitude of data illustrating the importance of cytokine-mediated activation, as well as accumulating evidence for stable alterations in the intracellular signalling of ... address only part of the several pathways that have been linked to Src and FAK signalling and that are of interest for enhancing our under- standing the complex natur...

Ngày tải lên: 09/08/2014, 01:22

... in various metal- binding proteins. Interestingly, the primary amino-acid composition of these domains is unlike that of other metal-binding domains, such as an EF-hand [59]. As the primary and ... TOC1 has an amino- terminal signaling-domain related to response receivers, a carboxy-terminal domain that could participate both in metal binding and in transcriptional regulation,...

Ngày tải lên: 10/08/2014, 09:20

... performed as a meta- analysis of our own mouse 430 2.0 dataset together with the published U74Av2 datasets. The Array Comparison support information of the NetAffyx™ analysis center (Affymetrix) was ... public accessibility of the datasets analyzed in the paper are given in Table 1. To verify the quality of the datasets mentioned above, we ana- lyzed signal int...

Ngày tải lên: 14/08/2014, 08:20

... metastatic melanomas. Using the human data as a filter, Chin and her colleagues identified a metastatic melanoma signature of 360 genes. Testing these genes in an in vitro functional assay of invasion ... aimed at elucidating the roles of the Aurora A family. Using a variety of mouse models with different levels of Aurora A expression, they found that a thresh...

Ngày tải lên: 14/08/2014, 20:22

... (NLS and NES), tandem K-homology domains (KH1 and KH2) and an RGG box, suggest that FMRP may shuttle in and out of the nucleus and that it may have an RNA binding activity. Nevertheless, the actual Keywords 3 Drosophila ... chromosome at the FRAXA locus, Xq27.3. The fragility is associated with an expansion of CGG repeats upstream of the fmr1 gene, which also causes increa...

Ngày tải lên: 30/03/2014, 15:20

... between inflammation and ossification in the pathogenesis of AS. The classification, genetic susceptibility, pathology, and response to treatment of spondyloarthritis have been evaluated into ... Sharma SM, Choi D, Planck SR, Harrington CA, Austin CR, Lewis JA, Diebel TN, Martin TM, Smith JR, Rosenbaum JT: Insights in to the pathogenesis of axial spondylartropathy...

Ngày tải lên: 12/08/2014, 11:22