Báo cáo y học: "Obesity affects the chondrocyte responsiveness to leptin in patients with osteoarthritis" doc

... obese patients may interfere with the transcriptional machinery and may lead to the loss of cell sensitivity to leptin. The responsiveness to the adipokine was then restored in chondrocytes from obese ... expression of leptin in cartilage compared with lean patients, indicating that local hyper- leptinemia may be found in the joint. Interestingly, obe- sity i...

Ngày tải lên: 12/08/2014, 14:22

... hap- pen in the reality of the IMSS, and other health care sys- tems in developing countries. Regarding the time horizon, this assessment is in line with the reported timelines used by other researchers ... researchers in the lit- erature, specially the time needed to control the articular pain [45]; it is honest to say that with the timeline employed in our...

Ngày tải lên: 13/08/2014, 11:22

... the presence of a cyclothymic temperament in the absence of impaired circadian rhythm (patients 1 and 4) ) was associated to refractoriness to agomelatine within 3 months of 50 mg/day therapy. ... disor- ders (including OCD) by causing disruptions in individuals’ social routines and, in turn, their biological rhythms according to the ‘ social zeitgeber’ the ory [41], even...

Ngày tải lên: 09/08/2014, 01:21

... mostly of IgG and not of IgE type, despite clinical symptoms indicating type I allergic reactions. The clinical relevance of measuring these antibodies is currently being investigated. In summary, ... led to withdrawal of infliximab. Other infusion reactions were characterized by more nonspecific symptoms. Discussion The main findings in the present study are that positive ANA sta...

Ngày tải lên: 09/08/2014, 08:22

... V, Martin A, Baron D, Pennec Y, Botton E, Mary JY, Le Goff P, Youinou P: Ability of the American College of Rheumatology 1987 criteria to predict rheumatoid arthritis in patients with early arthritis ... criteria for early RA. Although the 1987 ACR criteria lack specificity for early RA diagnosis [18], they remain widely used in patients with early arthritis in the abse...

Ngày tải lên: 09/08/2014, 14:22

... from study day 1 to 12. †Indicates the number of days alive without delirium from study day 1 to 12. § Indicates the number of days alive without coma from study day 1 to 12. ‡Indicates the number ... associated with a reduction in pro-inflammatory cytokines in patients with sepsis rela- tive to midazolam [54] and propofol [55]. It is plausible that hemodynamic-stabili...

Ngày tải lên: 13/08/2014, 20:21

... decisions. Moderate increases in plasma in plasma DNA may be asso- ciated with the chronic inflammatory response to athero- sclerotic process which often occurs in elderly patients [28]. In our study there ... coronary artery in eight and the circumflex in seven. Four patients had more than one artery involved. Eighteen patients were treated with mild therapeut...

Ngày tải lên: 13/08/2014, 20:21

... attending car- diology clinic at Yuzuncu Yil University Hospital. The study was approved by the local ethics committee according to the declaration of Helsinki, and patients gave written informed ... sig- nificantly lower in patients with CAD compared to the control group. Other investigators have also re- ported decreased retinol levels in patients with CAD (31...

Ngày tải lên: 25/10/2012, 10:51

... respiratory disease, especially in men, pointing to a link between psychologi- cal factors and chronic pulmonary disease [19]. Patients with COPD cannot cope adequately with everyday needs. This inadequacy ... are the group with the higher and more severe depression comor- bidity. Depression in patients with chronic respiratory dis- eases coexists with anxiety and is r...

Ngày tải lên: 08/08/2014, 23:20

... glutamate, g-aminobutyric acid, dopamine, serotonin, norepinephrine) and, ulti- mately, to the development of delirium [1]. The endoplasmic reticulum protein sigma-1 receptors play a key role in Ca 2+ signalling ... positron emission tomography demonstrated that fluvoxamine binds to sigma-1 receptors in living human brain at therapeutic doses, suggesting that sigma-1 receptors mig...

Ngày tải lên: 08/08/2014, 23:21