Báo cáo y học: "Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis" docx

... properly cited. Research article Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental ... combination of anti-TNFα mAb and IL-1RA. Statistical analysis was calcu- lated by one-way analysis of variance and Dunnett's multiple compari...

Ngày tải lên: 12/08/2014, 14:22

... IL-1β, forward 5'- CCCAAGCAATACCCAAAGAA-3', reverse 5'-CATCAGAG- GCAAGGAGGAAA-3'; for monocyte chemoattractant pro- tein-1 (MCP-1), forward 5'-AGCCAGATGCAGTTAACGC-3', reverse ... loss of articular cartilage. (c) Section from THR0921 treated CIA mouse showing nearly intact articular carti- lage and subchondral bone, and less synovial hyperplasia. (d) Mea...

Ngày tải lên: 09/08/2014, 07:20

... sensitivity and specificity. In the previous issue of Arthritis Research & Therapy, Schwartz and colleagues demonstrated the potential value of urinary TNF-like weak inducer of apoptosis (uTWEAK) as ... rheumatoid arthritis and ischaemic injury has anti- inflammatory effects [5]. In the current paper by Schwartz and colleagues, TWEAK was assessed as a biomarker for LN in...

Ngày tải lên: 09/08/2014, 14:22

Ngày tải lên: 11/08/2014, 17:21

... sites. Conclusion The availability and persistence of cartilage-derived SLRP catabolites in synovial fluids and the peripheral circulation will be essential parameters to validate in order to establish efficacious ... diseases. Glycobiology 2002, 12:107R-116R. 5. Imai K, Hiramatsu A, Fukushima D, Pierschbacher MD, Okada Y: Degradation of decorin by matrix metalloproteinases: iden...

Ngày tải lên: 09/08/2014, 07:20

... S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick ... computational analysis. WS and DH analyzed the data. WS, DH and ML wrote the manuscript. All authors read and approved the final manuscript. Acknowledgements We thank Benjamin Haley for shari...

Ngày tải lên: 09/08/2014, 20:21

... regulatory pathway of amino acid biosynthesis. Starvation for any amino acid induces the translation of Gcn4 via Gcn2. Gcn4 is a transcriptional activa- tor of enzymes that catalyze several amino ... recent accumulation of high throughput biological data, the task of integrating and analyzing large-scale data- sets is a major challenge. A variety of computational modeling...

Ngày tải lên: 14/08/2014, 08:20

... detected by comparative hybridization to a DNA microarray. Standard technical recommendations common to all microarray experiments (for example, the need for dye swaps) apply equally to ChIP-chip ... log ratios are independent, identically distributed, and random variables, having a Gaussian distribution with a mean of zero. The variance of the observations is estimated by the ave...

Ngày tải lên: 14/08/2014, 15:20

... incorporated belong to the caa 3 -andba 3 -type cytochrome c oxidases, respectively. The caa 3 -oxidase contains analogous central subunits and catalytic entity to the mitochondrial aa 3 - oxidases, ... contributions from the formyl groups and from the geranyl side chain expected from heme a and a 3 . In addition to the signals of the hemes, the reorgan- ization of the pol...

Ngày tải lên: 21/02/2014, 15:20

... a dose increase as a dependent variable and DAS28 at week 22, delta DAS28 0–22 and delta DAS28 6–22 as covariates, only DAS28 at week 22 was a significant variable in the model. Similar analyses ... included the physician's global assessment of disease activity (VAS), which is investigator- dependent and has the draw-back that it cannot be calculated by a study nurse. All...

Ngày tải lên: 09/08/2014, 06:23