Báo cáo y học: "Mechanical signals control SOX-9, VEGF, and c-Myc expression and cell proliferation during inflammation via integrin-linked kinase, B-Raf, and ERK1/2-dependent signaling in articular chondrocytes" pot

... Mechanical signals control SOX-9, VEGF, and c-Myc expression and cell proliferation during inflammation via integrin- linked kinase, B-Raf, and ERK1/2-dependent signaling in articular chondro- cytes ... [12,13]. Integrin-linked kinase (ILK), located in the cytoplasmic domain of integrins, plays a key role in transmitting mechanical signals to th...

Ngày tải lên: 12/08/2014, 14:21

... three enzymes that covalently modify pro- teins via ADP-ribosylation during the infection cycle: Alt, ModA and ModB. Alt is injected with phage DNA to immediately initiate ADP-ribosylation of ... toxin/antitoxin family: YoeB and RelE [29]. YoeB and RelE are involved in the inactivation of mRNA translated under nutritional stress conditions [30,31]. Interestingly, like RegB, RelE,...

Ngày tải lên: 11/08/2014, 21:21

... before and during study treatment. Following randomisation, mean FEV 1 increased during treatment, with a tendency to reach a plateau earlier in higher GINA treatment steps. BUD/ FORM maintenance and ... Within each GINA treatme nt step, the BUD/FORM maintenance and reliever therapy Figure 2 Mean FEV 1 by visit and GINA step at study entry. BUD/FORM maintenance and reliever th...

Ngày tải lên: 12/08/2014, 13:22

... DR, Finfer S, Talmor D: Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. Can Med Assoc J 2009, 180:821-827. 15. Finney SJ, ... 2005, in which the study of anti- in ammatory compounds was severely hindered by lack of standardization in the total treatment for patients with severe sepsis, with too many confounding...

Ngày tải lên: 13/08/2014, 21:21

... Malaysia 2. Faculty of Biotechnology, Malaysia University of Science and Technology, Petaling Jaya 47301, Malaysia 3. Discipline of Medicine, Blackburn Building D06, University of Sydney, NSW ... found to be geographically distributed. Genotype A is predominant in Northern Europe and North America. Genotypes B and C are observed mainly in Asia including China, Japan and Sout...

Ngày tải lên: 02/11/2012, 10:14

... was detected and quantified by coupling the conversion of phosphoenolpyruvate to pyruvate by pyru- vate kinase, and the conversion of pyruvate to lactate by lactate dehydrogenase. In this final ... immunobloting E.colistrains containing recombinant pET15b or p996A458 were cultured for 2–4 h in L broth containing ampicillin, tetracycline and 0.1 or 1 m M IPTG. The bacterial cells wer...

Ngày tải lên: 17/03/2014, 10:20

... pomifera 98% Intracellular cytokine staining in CD4 + T cellsFigure 2 Intracellular cytokine staining in CD4 + T cells. CD4 + T cells from the lung or bronchial lymph nodes (BLN) from either TCR-HA control ... 1 TIMP2 Array 2 TIMP3 Array 1 TIMP3 Array 2 0 1000 2000 3000 4000 5000 6000 1 day 3 day 6 day Gelsolin Array 1 Gelsolin Array 2 Tubulin Array 1 Tubulin Array 2 Vimentin Array...

Ngày tải lên: 12/08/2014, 15:20

... to Syk (Spleen tyrosin e kinase) which is involved in BCR signaling, but also in the regulation of integrin activation [44]. Moreover, recent work indicates that Syk is involved in CXCL12- and ... leading to inhibition of B -cell activation by phosphorylation of the protein tyrosine phosphatase SHP-1 (Src homology region 2 domain-containing phosphatase 1) via the immunoreceptor ty...

Ngày tải lên: 12/08/2014, 15:21

... standard insulin group and 83 of 254 (32.7%) in the intensive insulin group. The mean calorie intake in 24 hours was 23.1 ± 12.7 kcal/kg in the standard insulin group and 25.5 ± 14.4 kcal/kg in the intensive ... Patients were randomly assigned to receive either intensive insulin therapy to maintain glucose levels between 80 and 110 mg/dl (4.4 to 6.1 mmol/l) or standard insulin t...

Ngày tải lên: 25/10/2012, 10:35

... containing Steinmann pins, intrame- dullary nails with two lag screws and Charnley prostheses, respectively [5]. The authors reported that all constructs based upon the Charnley prostheses and ... not be rou- tinely inserted into hip spacers in clinical practise, but only in exceptional cases for patients with a higher fracture risk (high Body-Mass-Index, poor bone qual- ity or os...

Ngày tải lên: 26/10/2012, 09:53