Báo cáo y học: "Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor α but not estrogen receptor " pot

... inflammatory infiltrates and decreased levels of proinflammatory cytokines in CIA joints. Conclusions: ERα, but not ERβ, is key in ER -mediated suppression of experimental arthritis. It remains ... setting. Discussion Our main finding is that estrogen -mediated suppression of inflammation as seen in the TT-DTH response and in experimental arthritis is...

Ngày tải lên: 12/08/2014, 14:21

... for therapeutic purposes is now one of the ‘holy grails’ in immunology and much effort is focused on the exploitation of this therapeutic avenue. In the last issue of Arthritis Research & Therapy, ... responses. Their possible role in autoimmunity and more specifically in rheumatoid arthritis (RA) has been highlighted by a string of reports, one of which i...

Ngày tải lên: 09/08/2014, 06:23

... vessels in the highly vascular endothelium expressed CCL5 protein (Figure 6). In addition, staining was demonstrated at the synovial lining and on many infiltrating inflammatory cells. Protein levels ... properties. Immunohistochemical staining of synovial tissue Synovial tissue was collected at the time of synovial biopsy or therapeutically indicated arthroplasty and snap fro...

Ngày tải lên: 09/08/2014, 07:20

... randomly distributed across the United Kingdom. Genotype data gener- ated from the 64 non-White individuals included in the cohort was not included in the analysis. Of the available samples, genotyping ... controls were included across the plates to ensure accuracy of genotyping. In addition, for all the assays, genotyping was confirmed in a subset of samples usi...

Ngày tải lên: 09/08/2014, 08:22

... representative cytokines of a Th1 and Th2 profile, respectively. Indeed, intracellular IFN-γ staining, but not IL-4 staining, was detected in our T-cell lines, confirming the Bio-Plex data (Figure 3a). Discussion In ... (IC) staining of PMA (phorbol 12-myristate 13-acetate)/ionomycin activated T cells. (a) We detected interferon (IFN)-γ staining but no interleukin (IL)-4 stai...

Ngày tải lên: 09/08/2014, 08:22

... previously hypothesized that the Rev M10 protein inhibits wild-type Rev function by formation of mixed- multimers with wild-type Rev protein [19,20]. The find- ings in this study, and that of Berchold ... challenge that hypothesis since the mere pres- ence of SIV RRE in the producer cell seemed to obtund the inhibitory effect of Rev M10 on wild type Rev. The reasons fo...

Ngày tải lên: 10/08/2014, 05:21

... reveals a hypoaesthesia in the median nerve area of the left index and thumb compared to the contralateral side. Electromyography showed prolonged sensory latency in the distribution of the median ... 46-year-old man presented with a six month history of gradually worsening numbness and paresthesia on the palmar aspect of the left thumb and thenar eminence. Clinical...

Ngày tải lên: 10/08/2014, 10:20

... follow up there is no evidence of recurrence. Introduction Ninety percent of chromaffin-cell-originating tumors are located in the adrenal gland and termed pheochromocy- tomas. The remaining ten ... incidental [1]. Clinical symptoms may be related to catecholamine hypersecretion (hypertention/ hyperhydrosis) or to a mass effect resulting in complains of hoarseness, dysphagia,...

Ngày tải lên: 10/08/2014, 10:20

... S, Nishiwaki A, Morita H, Miyake T, Ogura Y: Effects of periocular administration of triamcinolone acetonide on leukocyte-endothelium interactions in the ischemic retina. Invest Ophthalmol Vis ... was defined as the distance between the inner limiting membrane and the retinal pigment epithelium (including any ser- ous retinal detachment), and was automatically mea- sured by com...

Ngày tải lên: 11/08/2014, 03:20

... increase of the pressure within the fluid-filled cyst during muscle exertion, thus resulting in haemodynamically significa nt endoluminal stenosis [6]. Communication of the cysts with the synovial ... col- lections of mucinous material con taining varying combi- nations of mucopolysaccharides and mucoproteins within the adventitial layer of the artery. The cysts exer...

Ngày tải lên: 11/08/2014, 12:20