Báo cáo y học: " Vascular alterations upon activation of TGFβ signaling in fibroblasts - implications for systemic sclerosis" potx

... of TβRIIΔk-fi b mice with increased expression of latency-associated peptide -TGFβ1 (LAP -TGFβ1 ) and TGFβ1 in the adventitia and accumulation of phosphory- lated Smad 2/3. Of note, TGFβ signaling ... signaling in the vascular pathology of SSc. Abbreviations SSc = systemic sclerosis; TβRII = TGFβ receptor type II; TβRIIΔk = kinase- de cient TGFβ receptor type II;...

Ngày tải lên: 12/08/2014, 14:21

... a stress-induced enhance- ment of skin DTH. Immunoneutralization of IFN-c in wild-type mice significantly reduced the stress-induced enhancement of skin DTH. In addition, an inflammatory response ... bear in mind that the heterogeneity of the stress-induced changes in leukocyte distribution 2 suggests that using equal numbers of leukocytes in a functional assay may not acc...

Ngày tải lên: 08/08/2014, 21:20

... an anti-phosphotyrosine antibody (PY-20), phos- phorylated Syp levels were visualized by immunoblotting with an anti-Syp antibody. Determination of actin was used as the control for loading. Representative ... and insu- lin sensitive as a result of enhanced insulin receptor signaling to IRS-1 [46], which suggests that elevated activity of SHP-1/ Syp could reduce IGF-1 signaling t...

Ngày tải lên: 09/08/2014, 08:23

... non-trans- duced, or transduced but with a low level of TK expres- sion, were treated with GST-Tat and briefly selected for inducible HSV-TK expression in hypoxanthine, aminop- terin and thymidine ... protein- RNA and protein-protein interactions [13]. Tat interacts with the core RNA polymerase II [14,15], the TATA-bind- ing protein associated factor (TAFII) [16], TFIIH [17], cyc- lin-d...

Ngày tải lên: 13/08/2014, 05:21

... organs incl uding post-cardiac arrest brain injury, post-cardiac myocardial dysfunction, systemic ischemia/reperfusion response and persistent pre- cipitating pathophysiology [1]. Post-cardiac ... adrenal dysfunc- tion [1,5]. Post-cardiac arrest syndrome is a mixed con- dition of systemic inflammatory response s, hypovolemia, and myocardial dysfunction. During severe illness, including...

Ngày tải lên: 14/08/2014, 07:21

... 17:2 0- 26. 8. Birman-Deych E, Waterman AD, Yan Y, Nilasena DS, Radford MJ, Gage BF: Accuracy of ICD-9-CM codes for identifying cardiovascular and stroke risk factors. Med Care 2005, 43:48 0-4 85. ... and pharmacy claims for RA patients participating in the longitudinal VA RA registry (VARA). For individuals initiating a new biologic agent or non-biologic disease-modifyin...

Ngày tải lên: 25/10/2012, 10:45

... distribu- tions of refractive status were further analyzed by dividing the children into three age groups: 6-8 -year-old (Grades 1-3 ), 9-1 2-year-old (Grades 4-6 ), and 1 3-1 5-year-old (Grades 7-9 ). ... living in 2552 households were selected, and 3070 were examined. The distributions of refractive status were positively-skewed for 6-8 -year-olds, and negativel...

Ngày tải lên: 25/10/2012, 11:40

... Potentially, this has clinical ramifications as a number of mutations in persistent hyperinsulinaemic hypoglycaemia of infancy [12] cluster in this domain of the protein. Persistent hyperinsulinaemic hypoglycaemia ... Leaney, J.L., Milligan, G. & Tinker, A. (2000) The G protein a subunit has a key role in determining the specificity of coupling to, but not the activation of...

Ngày tải lên: 31/03/2014, 08:20

... reduced N-methyl-D-aspar- tate glutamatergic transmissio n as well as changes in the activity of crucial neurotransmitters involved in the patho- physiology of depression, including dopamine and ... NS Dizziness 0 0 - - Blurred vision 0 0 - - Ringing in ears 0 0 - - Difficult urination 0 4 (16.7%) 6.720 0.010 Painful urination 0 0 - - Pollachiuria 0 4 (16.7%)...

Ngày tải lên: 09/08/2014, 01:21

... pyridinoline is most abundant in cartilage and bone. Urinary excretion of deoxypyridinoline is therefore used clinically as a marker of bone metabo- lism, whereas urinary excretion of pyridinoline ... consist of two major molecules, namely pyridinoline and its analogue deoxypyridinoline. Although both crosslinks are located in several tissues, deoxypyridinoline is more specificall...

Ngày tải lên: 09/08/2014, 01:23