Báo cáo y học: " Role of ADAM and ADAMTS metalloproteinases in airway diseases" pot

... breathless- ness) and airway obstruction. Hallmarks of asthma are mainly airway hyperresponsiveness caused by a wide vari- ety of stimuli and airway inflammation involving eosi- nophils and mast cells. ... activity of several members of the ADAM family [28- 31]. N-terminal domain of TIMPs and more specifically the "functional binding edge" is interacting wi...

Ngày tải lên: 12/08/2014, 14:20

... Netherlands, 4 Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA, 5 Institute for Anatomy and Cell Biology, Julius-Maximilians-University, ... bronchoconstriction. Background Serotonin (5-hydroxytryptamine, 5-HT) causes constric- tion of murine airways that is sensitive to atropine both in vivo...

Ngày tải lên: 12/08/2014, 16:20

... during peak viremia, mean lysis was 38.0% (ranging between 11 and 96%) tested in control and vaccinated monkeys. Lysis values increased further during chronic infection up to mean levels of 63.1% (range ... env-spe- cific IgG were weak but mainly detectable in the systemi- Table 2: Induction of complement-mediated lysis monkey %lysis day of challenge %lysis 2 wpc viral load 2 wp...

Ngày tải lên: 12/08/2014, 23:21

... high concentration Next, we investigated the involvement of intracellular Zn levels in the induction of apoptosis by cotreatment of 1 l M Py and 25 l M Zn (Py/Zn treatment). Determination of trace elements in Py/Zn-treated ... family of cysteine proteases, play a pivotal role in the execution of apoptosis [26]. We therefore examined the involvement of caspases in the...

Ngày tải lên: 23/03/2014, 21:20

... comparative terms, the Kenyan estimate of 10% of the Ministry of Health budget is lower than that of the Netherlands and Table 1: Annual cost of operating and organizing psychiatric services in Kenya (1 US$ ... those borne by the health care system and the family in directly addressing the problem of MBD; and (b) the indirect costs, i.e. loss of productivity caused b...

Ngày tải lên: 08/08/2014, 20:23

... of the BMP and WNT pathways following mechanical injury in vitro and in vivo, which may play a role in the reparative response of the joint surface. These pathways may, therefore, represent potential targets ... signaling pathways involved in embryonic skele- togenesis and joint morphogenesis, suggesting that the artic- ular cartilage is capable of triggering a signaling...

Ngày tải lên: 09/08/2014, 08:22

... dimethyloxaloylglycineEffects of 2-methoxyestradiol and dimethyloxaloylglycine. Effects on synovial tissue, levels of hypoxia-inducible factor (HIF) 1α and viability of chondrocytes, and the ... Induction of osteoarthritis by 2-methoxyestradiol demonstrates the importance of HIF-1 in maintaining the integrity of hypoxic articular cartilage. Stabilization of HIF-1 by dim...

Ngày tải lên: 09/08/2014, 13:22

... pathway involved in acid secretion induced by low taurine concentrations may predominantly involve in cholinergic neurons. Both TTX and atropine comple- tely inhibited the acid secretion induced by ... Biochemistry and physiology of taurine and taurine derivatives. Physiol Rev 1968, 48:424-511. 3. Ueki I, Stipanuk MH: Enzymes of the taurine biosynthetic pathway are expressed in...

Ngày tải lên: 10/08/2014, 05:21

... are obviously strictly related to reduce the risk of death and to minimize the complica- tions by excluding proximal intimal tear, removing asso- ciated aneurysmal disease and maintaining a complete distal ... imaging in the acute phase (within 14 days after the onset of symp- toms). The signs of impending rupture were determined by persisting pain despite adequate an d aggressive...

Ngày tải lên: 10/08/2014, 09:22

... of 7 Plasma levels of pro and anti-inflammatory cytokines Plasma levels of IL-6, TNF-a and IFN-g were significantly higher in patients; t he levels of the anti-infl ammatory cytokines IL-10 and ... expression of adhesion molecules of the endothelium and synthesis of other pro-inflammatory cytokines such as IL-1 and IL-6. Similar to results regarding pro-inflammatory...

Ngày tải lên: 11/08/2014, 03:20