Báo cáo y học: " Inhibition of SOC/Ca2+/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells" pps
Báo cáo y học: " Inhibition of SOC/Ca2+/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells" pps
... results indicated that therapeutic effects (vasodila- tion/antiproliferation) of sildenafil was involved in inhi- bition of the SOC/Ca 2+ /NFAT pathway. Additionally, activation PKG pathway by sildenafil ... citation purposes) Sildenafil inhibits hypoxia-induced up-regulation of TRPC1 expression in human PASMC TRPC-encoded proteins may be involved in the molecula...
Ngày tải lên: 12/08/2014, 14:20
Báo cáo Y học: Two 1 : 1 binding modes for distamycin in the minor groove of d(GGCCAATTGG) docx
... DNA conformation One of the most important effects of drug binding on the DNA conformation is the widening of the minor groove as illustrated in Fig. 6. The width of the groove is measured by taking ... A ˚ resolution. Whereas for one crystal the distamycin orientation and binding site is the same as in 12-dista, the orientation of the drug is inver...
Ngày tải lên: 24/03/2014, 04:21
Báo cáo y học: "Small ruminant feed systems: perceptions and practices in the transitional zone of Ghan" docx
... to the in sit u grazing of such species, and not an indic ation of being less impor- tant, which issue was discussed in the previous section. Considering how the feed system was defined in this study, ... the individual with a typical member of the group on what constitutes the domain of small ruminant feeds. The longer a list, the higher the ten- dency t o m...
Ngày tải lên: 10/08/2014, 09:21
Báo cáo y học: " GM-CSF and IL-2 as adjuvant enhance the immune effect of protein vaccine against foot-and-mouth disease" pot
... Cytokines as molecular adjuvant play a critical role in differentiation of effector T cell subsets and in determination of the magnitude of the response after vaccination. In this study, we investigated ... showed the highest level of mRNAs of either Th1 or Th2 cytokines. Expression of the cytokines in the groups with single cytokine co-expressed or mixed with VP...
Ngày tải lên: 11/08/2014, 21:21
Báo cáo y học: " A single site for N-linked glycosylation in the envelope glycoprotein of feline immunodeficiency virus modulates the virus-receptor interaction" ppt
... conserved in the majority of field strains of FIV. The location of these mutations, T271I and N34 2Y, is strikingly similar to previously described N- linked glycosylation sites in the Env of SIV ... mutation in 3 of 3 cats [87], suggesting a strong selective pressure in favour of either reinstating the N-linked glycosylation sites following infection or suppress...
Ngày tải lên: 13/08/2014, 05:21
Báo cáo y học: "Functional constraint and small insertions and deletions in the ENCODE regions of the human genome" ppsx
... evolutionary constraint. Hence, the explanation for this potentially counterintuitive observation is probably that the indel polymorphisms are largely confined to the gene deserts, whereas the constrained ... that one or both of the assumptions may be false. The first assumption is that AR sequence is effectively functionless (and therefore neutral sequence), and the sec...
Ngày tải lên: 14/08/2014, 08:20
Báo cáo y học: "A novel scheme to assess factors involved in the reproducibility of DNA-microarray data" pdf
... In order to distinguish the separate sources of errors in the VSG interaction, additional variance analyses were performed with combinations of 2 slides: (i) by omitting slide 1 (S1; containing ... DEPOSITORY MAY BE SIMULTANEOUSLY OR SUBSEQUENTLY SUBMITTED TO GENOME BIOLOGY OR ANY OTHER PUBLICATION FOR PEER REVIEW; THE ONLY REQUIREMENT IS AN EXPLICIT CITATION OF, AND LINK T...
Ngày tải lên: 14/08/2014, 14:21
Báo cáo khoa học: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein doc
... Synoviolin on the production of Ab NCT is one of the essential cofactors of the c-secretase complex. We therefore investigated the effect of the Synoviolin-mediated degradation of NCT on Ab gen- eration. ... ubiquitination confer specificity to the ubiquitin system by directly interacting with the sub- strate proteins and helping to transfer ubiquitin to them. T...
Ngày tải lên: 23/03/2014, 04:20
Báo cáo y học: "Familial Polycythemia Caused by a Novel Mutation in the Beta Globin Gene: Essential Role of P50 in Evaluation of Familial Polycythemi" potx
... nature of oxygen binding with heme, and in turn, can change the affinity of Hb for oxygen. The majority of mutations affecting oxygen affinity result in high affinity Hb variants which result in ... mutation somewhere in the core. 4. Conclusion Family history of polycythemia in a subject with polycythemia should raise the suspicion for the presence of a hi...
Ngày tải lên: 08/08/2014, 16:23
Báo cáo y học: "Hereditary angioedema: beyond international consensus - circa December 2010 - The Canadian Society of Allergy and Clinical Immunology Dr. David McCourtie Lecture" pps
... defi- ciency in a plasma protein that interacts with many homeostasis pathways in the human body (C1INH inter- acts with the complement, coagulation, contact and fibrinolysis pathways). The incidence of ... administration of intervention therapy (such as infusion of pdC1INH, rhC1INH, bradykinin B2 rec eptor antagonist, or kallikrein inhibitor). It is recom- mended that patie...
Ngày tải lên: 08/08/2014, 21:20