Báo cáo y học: " Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease" ppsx

... from infants with pulmonary hypertension and from con-trol patients of similar ageFigure 2 Intensity of staining for (A) eNOS, (B) iNOS and (C) nNOS in lungs from infants with pulmonary hypertension ... early stage of pulmonary hypertension in infants with congenital heart disease. Additionally there is co-expression of these two enzymes in pulmonary en...

Ngày tải lên: 12/08/2014, 14:20

... revealed that insulin resistance is associated in humans with reduced intracellular antioxidant (11). Interestingly, antioxidants improve insulin sensitivity and help in wound healing (16,17). ... or- ganelles and enzymes, increased lipid peroxidation, and development of insulin resistance (7). The vascu- lar and systemic complications in diabetes are associ- ated with...

Ngày tải lên: 26/10/2012, 09:39

... determination of synovial autoantibody and immunoglobulin enrichment in biopsy materials obtained in clinical trials. Immunoglobulin mRNA correlated with synovial protein levels, consistent with local ... immunoglobulin synthesis. Both anti-CCP and RF-IgM were significantly enriched in synovial tissues containing lym- phoid aggregates. However, in an 8-week study, autoantibody...

Ngày tải lên: 09/08/2014, 13:21

... whether circulating plasma cytokine profiles were associated with clinical involvement in SSc, plasma cytokines in patients with and without interstitial lung disease, pulmonary hypertension, SSc ... was only significantly increased in the ACA-positive subset. Lastly, patients with interstitial lung disease had elevated IL-6 and patients with pulmonary hypertension ha...

Ngày tải lên: 09/08/2014, 14:22

... prevented in part pulmonary hypertension, vas- cular remodeling and right ventricular hypertrophy induced by chronic hypoxia in mice [27]. However, the role of CXCR4 in pulmonary hypertension and remodel- ing ... migration in hyp oxia-induced pulmonary hypertension. We hypothe- sized that inhibition of systemic CXCR4 through admin- istration of AMD3100 wi ll inhibit hypo...

Ngày tải lên: 12/08/2014, 13:22

... activity of nitric oxide synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in ... findings of NO involvement in pathophysiol- ogy of hypobaric hypoxia in brain (42-43). In this study the increased activity of NOS in anoxia may represent predominantly the nN...

Ngày tải lên: 26/10/2012, 09:07

... addition, cytokines secreted by type 1 lymphocytes (Th1) and mac- rophages, including IL-1β, TNF-α, and IFN-γ, may be increased in asthma subjects and contribute to the inflam- matory process [2]. Inflammation ... C: Densit- ometry analysis of iNOS protein expression in SAECs nor- malized by β-actin (n = 3). D: Cytomix induced iNOS protein expressions in A549 cells within 6 hours...

Ngày tải lên: 12/08/2014, 14:20

... glands but the mechanism is still unknown precisely. In this study, we investigated potential signaling pathways involving protein kinase C (PKC) and mitogen- activated protein kinase (MAPK) in ... promoter activity and mRNA expression, mucin synthesis and ERK1/2 phosphorylation. The PKC inhibitors also inhibited the NOR-1 induced MUC5AC mRNA and MUC5AC protein synthesis by inhibi...

Ngày tải lên: 12/08/2014, 15:20

... of certain transcription factors, the expression of several pro-inflammatory and anti-inflammatory genes (including cytokines and cyclo-oxygenase), and the production of respiratory mucus [22–34]. In ... Higgs EA: Nitric oxide: physiology, patho- physiology, and pharmacology. Pharmacol Rev 1991, 43:109–142. 2. Weinberger B, Heck BE, Laskin DL, Laskin JD: Nitric oxide in the...

Ngày tải lên: 12/08/2014, 18:20

... myocardial infarction. Am Heart J 1939, 18:647-671. 5. Wildhirt AM, Dudek RR, Suzuki H, Bing RJ: Involvement of inducible nitric oxide synthase in the inflammatory process of myocardial infarction. Int ... peroxynitrite, which irreversibly inactivates proteins (including contractile proteins), suggest- ing that inhibiting the NO pathway probably comes too late and cannot restore an...

Ngày tải lên: 13/08/2014, 03:21