Báo cáo y học: " TGF-β1 induced epithelial to mesenchymal tr

Báo cáo y học: " TGF-β1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by " pot

... purposes) Respiratory Research Open Access Research TGF-β 1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1β but not abrogated by corticosteroids Astrid ... Chronic persistent asthma is characterized by ongoing airway inflammation and airway remodeling. The processes leading to airway remodeling...

Ngày tải lên : 12/08/2014, 14:20

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Báo cáo y học: "Gene expression and activity of cartilage degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblast" potx

... [13]. There is increasing evidence that SFs are key players in the pathogenesis of RA by invading and eroding hyaline cartilage. SFs, activated locally, produce a variety of cytokines, chemok- ines ... rather resulted from enzyme release by cells (including infiltrating inflammatory cells) within the joints. Competing interests The authors declare that they have no competing intere...

Ngày tải lên : 09/08/2014, 14:20

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Báo cáo y học: " TGF-β1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases" potx

... to the severity of the disorder. In a mouse model of airway remodeling induced by OVA sensitization and challenge, increased TGF-β1 was demonstrated by ELISA and immu- nohistochemistry with increased ... expression of bovine ASMCs in response to TGF-β1 by induction of TβRs [14]. TGF-β1 is likely to play an important role in airway remodeling in asthmatics. For ex...

Ngày tải lên : 12/08/2014, 16:20

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Báo cáo y học: "TGF-β1 and serum both stimulate contraction but differentially affect apoptosis in 3D collagen gels" ppt

... con- tributes to scar formation or fibrosis. The key finding of the current study is that augmented contraction induced by TGF-β is associated with apoptosis. This contrasts with augmented contraction induced ... contraction but not apoptosis. The ability of TGF-β to induce apoptosis may play a key role during wound repair. Abnormal regulation of apoptosis during the resolutio...

Ngày tải lên : 12/08/2014, 18:20

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Báo cáo y học: "Sigma-1 receptor agonist fluvoxamine for postoperative delirium in older adults: report of three cases" docx

... serotonin reuptake inhibitors (SSRIs), and that fluvoxamine is a potent sigma-1 receptor agonist [10-12]. Currently, it is unclear whether sigma-1 receptors were involved in the mechanism underlying the beneficial ... efficacy for the treatment of postoperative delirium in patients. Recent findings suggest that sigma-1 receptors might be involved in the different mechanisms of some...

Ngày tải lên : 08/08/2014, 23:21

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Báo cáo y học: " HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors" docx

... mutant to aptamer RT8 (Table 1) suggests that the residue N265 may not play a key role in binding to RT8. It is also interesting that N255D mutant displays a 10-fold hypersensitivity to RT8. We ... virus infectivity by 12- to 30-fold over wild type in a single round of infection using an LTR- lacZ reporter cell line [25]. In addition, during a multi-day replication experimen...

Ngày tải lên : 10/08/2014, 05:20

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Báo cáo y học: " Epigallocatechin-3-gallate (EGCG) inhibits the migratory behavior of tumor bronchial epithelial cells" docx

... to the migratory status of cells, suggesting that vimentin may play a fundamental role in cell migration. Moreover, vimentin expression was only found in human epithelial tumor cells lines displaying ... migration induced by EGCG was accompa- nied by a decrease in vimentin expression and organiza- tion. We hypothesize that the alterations of the vimentin network induced...

Ngày tải lên : 12/08/2014, 15:21

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Báo cáo y học: " HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-γc-/- (RAG-hu) mouse model" docx

... is created by injecting human peripheral blood mononuclear cells intraperitonially. Many elegant studies on HIV pathogenesis and passive immunity using monoclonal antibodies were conducted by ... that of NK cells which function to reject foreign grafts. Intravenous administration of human hematopoietic stem cells together with exogenous administration of human cytokines...

Ngày tải lên : 13/08/2014, 09:20

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Báo cáo y học: " The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells" potx

... early onset of cdk2 kinase activity [28,30]. Tax also has the ability to increase cdk4 associated kinase activity in HTLV-1 infected cells by binding to p16/INK4A, resulting in the inability ... The increased cyclin E/cdk2 associated kinase activity observed in HTLV-1 infected cells versus uninfected cells supports this theory. This is important since the cyclin E/ cdk2...

Ngày tải lên : 13/08/2014, 13:20

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Báo cáo y học: "TGF-β dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells" potx

... for 10 min at 4°C. SOD activity was measured by monitoring the autooxidation of 6-hydroxy-dopamine. Autooxidation is inhibited by 6-hydroxy-dopamine consuming superoxide generated during this process, ... are in line with data obtained by the analysis of NADPH oxidase, which showed strongly enhanced activity in M-HTs, indicating huge amounts of superoxide anion that has to be...

Ngày tải lên : 13/08/2014, 13:20

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