Báo cáo y học: " TGF-β1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by " pot

... purposes) Respiratory Research Open Access Research TGF-β 1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1β but not abrogated by corticosteroids Astrid ... Chronic persistent asthma is characterized by ongoing airway inflammation and airway remodeling. The processes leading to airway remodeling...

Ngày tải lên: 12/08/2014, 14:20

... [13]. There is increasing evidence that SFs are key players in the pathogenesis of RA by invading and eroding hyaline cartilage. SFs, activated locally, produce a variety of cytokines, chemok- ines ... rather resulted from enzyme release by cells (including infiltrating inflammatory cells) within the joints. Competing interests The authors declare that they have no competing intere...

Ngày tải lên: 09/08/2014, 14:20

... to the severity of the disorder. In a mouse model of airway remodeling induced by OVA sensitization and challenge, increased TGF-β1 was demonstrated by ELISA and immu- nohistochemistry with increased ... expression of bovine ASMCs in response to TGF-β1 by induction of TβRs [14]. TGF-β1 is likely to play an important role in airway remodeling in asthmatics. For ex...

Ngày tải lên: 12/08/2014, 16:20

... con- tributes to scar formation or fibrosis. The key finding of the current study is that augmented contraction induced by TGF-β is associated with apopto- sis. This contrasts with augmented contraction induced ... contraction but not apoptosis. The ability of TGF-β to induce apoptosis may play a key role during wound repair. Abnormal regulation of apoptosis during the resolutio...

Ngày tải lên: 12/08/2014, 18:20

... serotonin reuptake inhibitors (SSRIs), and that fluvoxamine is a potent sigma-1 receptor agonist [10-12]. Currently, it is unclear whether sigma-1 receptors were involved in the mechanism underlying the beneficial ... efficacy for the treatment of postoperative delirium in patients. Recent findings suggest that sigma-1 receptors might be involved in the different mechanisms of some...

Ngày tải lên: 08/08/2014, 23:21

... mutant to aptamer RT8 (Table 1) suggests that the residue N265 may not play a key role in binding to RT8. It is also interesting that N255D mutant displays a 10-fold hypersensitivity to RT8. We ... virus infectivity by 12- to 30-fold over wild type in a single round of infection using an LTR- lacZ reporter cell line [25]. In addition, during a multi-day replication experimen...

Ngày tải lên: 10/08/2014, 05:20

... to the migratory status of cells, suggesting that vimentin may play a fundamental role in cell migration. Moreover, vimentin expression was only found in human epithelial tumor cells lines displaying ... migration induced by EGCG was accompa- nied by a decrease in vimentin expression and organiza- tion. We hypothesize that the alterations of the vimentin network induced...

Ngày tải lên: 12/08/2014, 15:21

... is created by injecting human peripheral blood mononuclear cells intraperitonially. Many elegant studies on HIV pathogenesis and passive immunity using monoclonal antibodies were conducted by ... that of NK cells which function to reject foreign grafts. Intravenous administration of human hematopoietic stem cells together with exogenous admin- istration of human cytokines...

Ngày tải lên: 13/08/2014, 09:20

... early onset of cdk2 kinase activity [28,30]. Tax also has the abil- ity to increase cdk4 associated kinase activity in HTLV-1 infected cells by binding to p16/INK4A, resulting in the inability ... The increased cyclin E/cdk2 associated kinase activity observed in HTLV-1 infected cells versus uninfected cells supports this theory. This is important since the cyclin E/ cdk2...

Ngày tải lên: 13/08/2014, 13:20

... for 10 min at 4°C. SOD activity was measured by monitoring the autooxidation of 6-hydroxy-dopamine. Autooxidation is inhibited by 6-hydroxy-dopamine consuming superoxide generated during this process, ... are in line with data obtained by the analysis of NADPH oxidase, which showed strongly enhanced activity in M-HTs, indicating huge amounts of superoxide anion that has to be...

Ngày tải lên: 13/08/2014, 13:20