Báo cáo y học: " Asthma and genes encoding components of the vitamin D pathway" potx

... of SNPs in the vitamin D pathway genes with asthma and atopy in the SLSJ studyFigure 2 Genetic association of SNPs in the vitamin D pathway genes with asthma and atopy in the SLSJ study. Only ... required to produce the biolog- ically active form of vitamin D [1α,25-(OH) 2 D 3 ]. CYP27A1 and CYP2R1 genes encode enzymes with 25-hydroxylase activity...

Ngày tải lên: 12/08/2014, 14:20

... used in this study consisted of 60% Caucasian and 40% African- Americans, and 55% females and 45% males. All data were analyzed to consider the cofactors of race and gen- der. There was no difference ... monoclonal antibody + IL-2 + anti-IL-12, and then stimulated and analyzed for cytokine production by immunofluorescence-flow cytometry. Each symbol indicates the proportio...

Ngày tải lên: 12/08/2014, 11:22

... analysis All items were coded and scored, and the completed ques- tionnaires were included in the data analysis set. Individ- ual unanswered items were excluded from the analysis. Statistical Package ... community on the basis of their availability. They received a brief explanation of the purpose and the aim of the study, and those who agreed to participate were a...

Ngày tải lên: 08/08/2014, 21:20

... publications, extracted the data and wrote the materials and methods, results; YLX wrote the discussion and checked all data, JH was responsible for data synthesis, CT and CH helped designed the study’s analytic ... that they have no competing interests. Authors’ contributions HF designed the study, provided resources, coordinated the study and directed its implementatio...

Ngày tải lên: 12/08/2014, 11:22

... wrote the report. J.A. did the clinical survey, C.B. did the SNP analysis, M.B. built serum and DNA bank and did the vitamin D assays together with E.A. who supervised also laboratory work and did ... Caucasians. The evidence that the human CYP2R1 is a key vitamin D 25-hydoxylase is rather new [34] where the identity of the hepatic 25-hydroxylase has remained u...

Ngày tải lên: 12/08/2014, 16:20

... studies, the role of air pollutants in the development of disease is controversial. The large six-city study in the USA found no association between the incidence of asthma and the level of airborne particulates ... involve the generation of hydroxyl radicals by Fenton-type chemistry [26]. The imposition of an additional oxidative, pro-inflam- matory burden on...

Ngày tải lên: 12/08/2014, 18:20

... ≥ 0.22) and did not differ between genotypes overall (χ 2 : P = 0.51) (data not depicted). Unadjusted and adjusted odds ratios for spirometry defined COPD did not differ between geno- types (Fig. ... we had 90% power to detect an increase in FEV 1 decline of 8 ml, an odds ratio for self-reported asthma and spirometry-defined COPD of 1.9 and 1.7, and a hazard ratio for asthma...

Ngày tải lên: 12/08/2014, 18:22

... the nose and eyes (anti-histamines and/ or cromones) and inhaled short-acting beta-agonists during the day and night. The number of drugs in each category was calculated for each day and divided ... supported financially by the Swedish Association against Asthma and Allergy, the Swedish Heart and Lung Foundation and Bror Hjerpstedt's Foundation. References 1...

Ngày tải lên: 13/08/2014, 13:22

... confirmed by DNA sequencing. The BAC-EGFP 5.5 kb construct was directly amplified by PCR (Table S4 in Additional data file 1) upon the modified BAC and then cloned into the EcoRV site of the pBSKS+ ... of the other approaches employed genome-wide selection of co-expressed genes solely based on microarray expression profiles. This may recruit many genes that may belong to...

Ngày tải lên: 14/08/2014, 21:20

... wall of S. azureus RIA 1009 [24] and based on the analysis of the products formed upon acid and enzymatic hydrolysis. Acid hydrolysis afforded glucose and ribitol monophosphate, while a glycoside containing ... preparation was determined by its transfor- mation in 2-octyl glycoside and by comparison of the derivative obtained with standard samples of (S+)- and (R-)-2-o...

Ngày tải lên: 17/03/2014, 10:20