Báo cáo y học: " PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells" docx

... the cyclic AMP (cAMP) effectors protein kinase A (PKA) and exchange proteins directly activated by cAMP (Epac1 and Epac2 ) in the bradykinin-induced IL-8 release from a human airway smooth muscle ... IL-8 release in hTERT -airway smooth muscle cells by Epac and PKAFigure 12 Augmentation of bradykinin-induced IL-8 release in hTERT -airway smooth muscle c...

Ngày tải lên: 12/08/2014, 14:20

... K + channel activity and inhibits apoptosis in pulmonary artery smooth muscle cells. Apoptosis 2009, 14:42-51. 11. Wang LN, Wang C, Lin Y, Xi YH, Zhang WH, Zhao YJ, Li HZ, Tian Y, Lv YJ, Yang BF, Xu ... example, coronary artery is relaxed but pulmonary artery is con- tracted under hypoxic condition. Pulmonary vasocon- striction and PASMC proliferation may contribute to hypoxic pul...

Ngày tải lên: 10/08/2014, 05:21

... might primarily be due to detoxification of toxic aldehydes. The stimulation of AR synthesis under stress conditions points to a physiological role of these enzymes in plants exposed to environmental ... reaction, are catalysed by enzymes of the aldo-keto reductase (AKR) superfamily [8]. The members of the AKR superfamily are cytosolic, monomeric proteins that catalyse mainly the NAD(P)H...

Ngày tải lên: 18/03/2014, 01:20

... mono- meric and pol ymeric f orms. M and P s tand for activated myristic acid and palmitic acid, respectively. NMT, N-myritoyltransferase; PAT, palmitoylacyltransferase; a nd MPT, myritoylproteinth ... the F1 and F4 forms, w hich were both myristoylated and palmitoylated, the F3 form was only palmitoylated. The monomeric, trimeric and tetrameric forms o f PICE w ere all able to...

Ngày tải lên: 31/03/2014, 21:21

... both rheumatology and preventive cardiology to advocate more aggressive risk factor assessment and management of risk factors [11–17]. There are theoretical and practical barri- ers to improving ... that even if physicians were perfectly virtuous, sought out risk factors aggressively and followed guidelines scrupulously; and patients were toler- ant, compliant, and responsive...

Ngày tải lên: 09/08/2014, 01:22

... it unclear how many studies fail to identify a causal locus by exome sequencing. Non-allelic heterogeneity, regulatory variation and structural variation underlying phenotypes all pose challenges ... regression can improve the power to detect an association. For example, synonymous variants are typically discarded because they are less likely to be causal. Shrinkage and regul...

Ngày tải lên: 09/08/2014, 23:20

... [17,18]. The cytokine repertoire of DC matured in the presence of inflammatory stimuli com- prises pro-inflammatory cytokines and chemokines, including the T cell inhibitory cytokine IL-10, the ... are towards reduced expression of co- stimulatory makers and cytokines. In addition, monocytes from cryopreserved PBMC of cancer patients can be fully differentiated into mature DC with pheno...

Ngày tải lên: 11/08/2014, 10:23

... contributions AK and YD performed the operation. AK, YD and ANY were responsible for the pre- and postoperative manage- ment. AK, YD and TTS analyzed the literature and wrote the manuscript. ANY edited ... Department of Orthopaedics and Traumatology, Mustafa Kemal University Faculty of Medicine, 31100 Antakya, Hatay, Turkey Email: Aydıner Kalacı* - orthopedi@gmail.com; Yunus Dogra...

Ngày tải lên: 11/08/2014, 19:21

... cells and purified by immobilized metal affinity chromatography. Biotechnol Bioeng 1999, 63(6):721-9. 20. Senda M, Hirayama N, Yamamoto H, Kurata K: An improved hemagglutination test for study of ... while retaining physical and immunological properties. VP2 VLPs have been produced and purified using a specific affinity Immobilized Metal Affinity Chromatography (IMAC) system for other p...

Ngày tải lên: 11/08/2014, 21:21

... hypertrophy via increased myosin heavy chain expression; possibly due to an increase in myogenic regulatory factors myogenin and MRF-4 [31-33]. In the present study, we clearly noted a reduction in ... ability to perform high-intensity exercise via increased PCR availability and enhanced ATP synthesis, thereby enabling an a thlete to train harder to promote greater muscular hypert...

Ngày tải lên: 11/08/2014, 23:21