... S02, and S03, composed of 13 genetic polymorphismscovering two distinct promoter regions, were determined for 33JIA patients, including 17 with systemic JIA, 10 with polyarthritis, and 6 with ... func-tions. Interestingly, IL-18 is a unique cytokine that stimulatesboth T helper (Th)1- and Th2-type immune responses,depending on its cytokine milieu [3]. In combination with IL-12,IL-18 induces ... reported by other investigators and estimated the carry-ing rate of each haplotype in the disease populations. Interest-ingly, we found differently genetically skewed haplotypes in each disorder....