Báo cáo y học: " Macrophage derived chemokine (CCL22), thymus and activation-regulated chemokine (CCL17), and CCR4 in idiopathic pulmonary fibrosis" pdf

... pathophysiology are eagerly awaited. The thymus and activation-regulated chemokine, CCL17, and the macrophage- derived chemokine CCL22 are mem- bers of the CC chemokine family, and CCR4 was identi- fied as their ... inspiratory crackles. Open lung biopsy was performed in one IPF patient, and transbronchial lung biopsy (TBLB) in 11 patients without any atypical findin...

Ngày tải lên: 12/08/2014, 14:20

... mem- brane–cartilage interface [21,22]. Macrophage migration inhibitory factor (MIF) was originally identified as a protein derived from T lymphocytes [23,24]. MIF is a proinflammatory cytokine produced by macrophages ... AP-1 inhibitor (curcumin) [47]. In another study, MIF increased MMP-9 and MMP-13 mRNA in rat osteoblasts [52]. Genistein and herbimycin A (two tyrosine kinase in...

Ngày tải lên: 09/08/2014, 08:22

... manuscript. OT and NE participated in the design of the study and performed the statistical analysis. OY, NE, JM, YH and JK conceived of the study, and participated in its design and coordination and helped ... discriminate CPE from sepsis-induced ARDS [23-25], because th e plasma BNP level may increase due to myocardial dysfunction or the direct effect of inflam- matory media...

Ngày tải lên: 12/08/2014, 13:22

... residues bearing hydroxyl groups. PAP amidolytic activity was poorly inhibited by all currently used wide spectrum proteinase inhibitors. Only 3±4 dichloroisocoumarin and benzamidine inhibited puri®ed ... was measured in the presence of a molar excess of inhibitors from all four classes of proteases ) aprotinin, benzamidine, leupeptin, Soya bean t rypsin inhibitor (SBTI) 6,7 ,(1-trans- ep...

Ngày tải lên: 24/03/2014, 00:21

... TGFβ and assayed for sulphated proteoglycan production using the DMB assay [26]. Scoring of immunohistochemistry and toluidine blue staining Scoring of slides from immunohistochemical staining ... cell- surface markers, ECM proteins and toluidine blue staining of total proteoglycans was performed blinded by HG, HT and MK. The following scoring scale was used: 1 = very slight localisa...

Ngày tải lên: 09/08/2014, 10:23

... be secreted by macrophages, but not pl atelets, and they play important roles in mediating pro-inflammatory responses. Interestingly, the pro-inflammatory cytokine secretion was also enhanced by platelets ... apoptotic c ells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-bet a, PGE2, and PAF. J C lin Invest 1998, 101:890-898....

Ngày tải lên: 11/08/2014, 03:20

... play an integral role in maintaining vascular integrity. Within their 8-10 day lifespan, platelets can become activa ted either in the cir- culation or during adherence at a site of injury, and ... apoptotic c ells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-bet a, PGE2, and PAF. J C lin Invest 1998, 101:890-898. 5. Li Y...

Ngày tải lên: 11/08/2014, 06:22

... pFny209 containing CMV Rep gene (kindly provided by professor Jialin Yu, China Agricul- ture University) and the amplified fragments were inserted into pUCm-T (Shanghai Sango, Shanghai, China) ... PTGS by directly interfering with the activity of the mobile silencing signal [44,45]. Guerini and Mur- phy[46]reportedthatCapsicum annum cv. Avelar plants resisted systemic infection by the ......

Ngày tải lên: 11/08/2014, 21:22

... of the Rev -IN complex in virus- infected cells can be disrupted by three cell-permeable IN -derived peptides, the INrs (IN derived- Rev interact- ing peptides) [22] and INS (IN derived- integrase ... LEDGF/p75 binding to IN, was shown to significantly inhibit integration and virus infection due to its ability to interfere with the IN- LEDGF/p75 inter- action [12]. Finally, HI...

Ngày tải lên: 12/08/2014, 04:20

... FLS to inflammatory cytokines. The surprising and novel central finding of these stud- ies is the significant and striking synergistic effect of a combination of PDGF and TGF-β on cytokine-induced FLS ... synoviocytes in vitro was studied by quantitative Polymerase Chain Reaction (qPCR), ELISA and multiplex bead cytokine assays. Intracellular signaling pathway activation was deter...

Ngày tải lên: 12/08/2014, 12:20