Báo cáo y học: " Effects of cigarette smoke on endothelial function of pulmonary arteries in the guinea pig" ppsx
Báo cáo y học: " Effects of cigarette smoke on endothelial function of pulmonary arteries in the guinea pig" ppsx
... [2-4].Accordingly, the present study was addressed to investi-gate in the guinea pig the effects of chronic exposure to CS on the endothelial function of pulmonary arteries and the lung expression of endothelial ... participated in the analysis of the data and in the preparation of the manu-script. VIP was involved in the conception of the study,participated in its design and coordination, the analysis of the data ... smoking may contribute to pulmonary hypertension in chronicobstructive pulmonary disease by altering the structure and function of pulmonary vessels at earlydisease stages. The objectives of...
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Báo cáo y học: " Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung" docx
... Thus their actions in vivo depend on their specificconcentrations within the microenvironment of the alveolar wall during the course of adaptation to pulmonary hypoxia.Background Pulmonary hypertension ... pulmonary vasodilation with L-arginine in pulmonary hypertension. Circulation 1995, 92(6):1539-45.34. Mitani Y, Maruyama K, Sakurai M: Prolonged administration of L-arginineameliorates chronic ... example, the PO2 of the alveoli during the development of hypoxic pulmonary vasoconstriction and pulmonary hypertension is 5.0-8.0kPa, a value much higher than that of a systemic organunder conditions...
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Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt
... cysteine-rich,metal-binding proteins that function in the maintenance of metal homeostasis and detoxification by forming strongcomplexes with several types of metal ions [16,17]. Given the existence of MREs in the ... cation-trans-porting P-type ATPases [1–5] and functions in the bindingand translocation of copper [6].Interestingly, multiple copies of metal-response elements(MREs) are located in the 1.3-kb promoter of the ... the MREa-binding proteins are immunologically rela-ted to the Ku proteins. To study further the functionalsignificance of these Ku-related proteins in transcriptionalregulation of the WD gene,...
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Báo cáo y học: "β Treatment with recombinant interferon-β reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis" ppt
... hyperplasia of the intimal lining layer and cell infiltration of the synovial sublining weredetected and a decrease in bone erosions was observed. (b) Infiltration of inflammatory cells of the joints ... whether IFN-β isinfluencing monocyte recruitment, survival, and/orretention in the synovial joint.Alternatively, IFN-β may inhibit inflammatory cell infiltrationindirectly, via suppression of ... IFN-β), indicating that the reduced cytokineproduction we observed may be explained in part by the inhibition of NF-κB activity by IFN-β in RA FLS (Fig. 8).Discussion The results presented in this...
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Báo cáo y học: "Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis" doc
... other cytokine production by monocytes [68,118,119]. Similarly, the pro-inflammatory effects of NPY in concanavalin A-induced paw edema in rat was potentiated byco-application of a DPPIV inhibitor ... finding in RA, although not consistentlyobserved in the synovial fluid (Table 1). Despite the inconsistency in reporting of differing DPPIV levels betweennon-inflammatory and inflammatory synovial ... cells infiltratinginto the synovium from the periphery. This concept stresses the kinetic nature of synovial inflammation where a single timepoint assay may identify a synovial population of CD26low‘spent’...
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Báo cáo y học: " TGF β-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7" pps
... of the syn-ovial lining, expansion of fibroblast population in the synovialconnective tissue, and continued collagen deposition [18].Injection of high amounts of TGF-β, either as a bolus injectionor ... restored the IL-1-induced reduction in PG content andincreased PG synthesis. TGFβ-induced an elevation in PGcontent in cartilage of the OA model. TGFβ-induced synovialfibrosis was strongly diminished ... damage by injection of interleukin-1 (IL-1) intomurine knee joints. After 2 days, we injected an adenovirusencoding TGFβ. On day 4, we measured proteoglycan (PG)synthesis and content. To examine...
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Báo cáo y học: " Part I, Patient perspective: activating patients to engage their providers in the use of evidencebased medicine: a qualitative evaluation of the VA Project to Implement Diuretics (VAPID)" ppsx
... of their hypertension. In addition, patientsprovided insight as to why the intervention was effective in increasing participation in the intervention. Many of their answers pointed toward findings ... following instruction appears to be ingrained in their reasoning for bringing in the letter. These indivi-dualsstatedtheyweresimplydoingwhattheletterrequested of them.‘For one thing I was ... didn’t take into considerat ion their co-morbidconditions.Motivations for bringing in the letter In addition to patients’ opinions of the inter vent ion let-ter, we analyzed the motivational factors...
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Báo cáo y học: " Isolated radial head dislocation, a rare and easily missed injury in the presence of major distracting injuries: a case report" ppsx
... radialhead. The reduction was achieved in supination andimmobilisation of the elbow in flexion and supinationgave a favourable final outcome. In the presence of major distracting injuries like long bonefractures, ... and splints applied to bothknees.12 hours later, the patient complained of pain in the rightelbow. There was no previous history of elbow injury orarthritis. On examination, there was minimal ... details, reviewing the literature and drafted the manuscript as the mainauthor.RSUY was involved in reviewing the literature and proofreading of the manuscript. RSUY has approved the finalmanuscript.SSB...
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Báo cáo y học: "B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin" pdf
... form of BLyS. The molecular mass of the heterotrimers wasconfirmed by SEC-MALS mass distribution LS/UV/RI3-detector analysis.Binding kinetics and affinity studies The binding affinities an d kinetics ... homotrimers. The reduced potency of the heterotrimer ligands in the pri-mary human B cell-proliferation assay compared with the homotrimeric BLyS may be explained by the predo-minant expression on circulating ... donors may explain the complexdiffere nces in dose-response curves observed in the pri-mary B-cell assay.Roschke et al. [6] also investigated the ability of solu-ble Ig fusion versions of...
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Báo cáo y học: " First Siena International Conference on Animal Models of " pptx
... astudy employing several strains of mice in which neu-trophil influx into the airways was induced by formyl-methionyl-leucyl phenylalanine instillation. This influxresulted in the development of ... the translation of informationgained from the development of animal models toimprovements in patient care. Specifically, the formalpresentations and informal discussions held during the conference ... may be of great benefit to the study of the mechanisms involved in the development of COPD were described. The impor-tance of animal and strain selection was stressed and the need to use cigarette...
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