Báo cáo y học: " MMP/TIMP expression profiles in distinct lung disease models: implications for possible future therapies" pot
Báo cáo y học: " MMP/TIMP expression profiles in distinct lung disease models: implications for possible future therapies" pot
... 3C).
Determination of MMP/TIMP mRNA levels in three
distinct in vivo models of airways disease
In vivo model of antigen induced airway inflammation
In the antigen induced airway inflammation ... observed in human airways disease, for
example, increased eosinophils in asthma, and increased
neutrophils and lymphomononuclear cells in inflamma-
tory airways diseases, such a...
Báo cáo y học: "Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis" docx
... useful information
about dysregulated genes, not only in synoviocytes but also
in other, neighbouring cells (myocytes, osteocytes and
chondrocytes) that may also contribute to disease
pathology.
In ... tissue injury during inflammatory and autoim-
mune diseases [30], and ficolins can initiate the lectin path-
way of complement activation through attached serine
proteases (Mannan-bindi...
Báo cáo y học: "Gene expression profiles in BCL11B-siRNA treated malignant T cells" ppt
... BCL-2 (Figure 2), may enhance
their binding to BCL-2, thereby inhibiting the anti-apop-
totic function. Thus, we analyzed the BCL-2 protein
expression level by flow cytometry in Molt-4 cells at ... phosphoprotein 1 (SPP1), cAMP-
response element binding protein (CREBBP), and b2-
MG were determined by real-time PCR using a SYBR
Green I qPCR Master Mix kit [15].
Flow cytometry assay
Cells f...
Báo cáo y học: " Gene expression variation in Down''''s syndrome mice allows prioritization of candidate genes" potx
... previously published
findings in Ts65Dn, in which investigations were performed
in an independent set of mice and with different chemistry
(TaqMan versus SYBR green or cDNA arrays) [19]. Indeed,
we ... observed in trisomy. By analyzing
RNAs pooled from several Ts65Dn mice in order to minimize
inter-individual variation, we and others demonstrated an
overall elevation in expressio...
Báo cáo y học: "Extracorporeal gas exchange in acute lung injury: step by step towards expanded indications" pot
...
Therefore, widening indications with the aim of
reducing ventilator induced lung injury (VILI) is still
controversial. Consequently, technological progress
is an important strategy. Miniaturized ... implications for the
use of such systems outside the conventional indication
of acute life-threatening hypoxemia.
Ever since its original description by Daniel Ashbaugh
and co-workers...
Báo cáo y học: "Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation" pps
... by
genes encoding interleukins, chemokine receptors and ligands,
and by those involved in antigen recognition and processing.
Keywords: DNA expression array, differential gene expression, inflammation, ... of molecular interactions in an
inflamed joint, deduced from gene expression studies in
both RA and its corresponding animal models, involves pro-
teins participating in immuni...
Báo cáo khoa học: "MicroRNA expression profiles in human cancer cells after ionizing radiation" pps
... [10].
Let-7 family members are down-regulated in lung
cancer cells [9] which possibly increases cell growth by
increasing KRAS levels [22]. Over -expression of let-7a,
which in the present study was up-regulated ... especially focusing on clinically relevant endpoints like radiation induced cell death,
proliferation, migration and metastasis.
Introduction
MicroRNAs are small non-coding...
Báo cáo y học: "Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis" doc
... significantly overexpressed at baseline in
poor responders are induced by several cytokines in FLSs,
thereby suggesting a role for these cytokines in the resistance
to TNF blockade in RA.
ANOVA: analysis ... thereby preventing disease progression
in these patients and saving unnecessary costs.
TNF antagonists interfere with many pathways involved in RA
synovial inflammatory pr...
Báo cáo y học: "Antiphospholipid antibody profiles in lupus nephritis with glomerular microthrombosis: a prospective study of 124 cases" pot
... may influence the dynamic equilibrium
between hemostasis and fibrinolysis by cross-reacting with
some hemostatic and fibrinolytic proteases (e.g., plasmin,
thrombin, t-PA, protein C, protein ... indices of renal tissue injury
Renal tissue injury was evaluated using activity and chronicity
indices as previously reported by Austin and colleagues [34].
The activity index was the sum of the ... e...
Báo cáo y học: "Degradome expression profiling in human articular cartilage" potx
... predominantly intracellularly [26,27]. Cathepsin H,
cathepsin C, cathepsin F, cathepsin W, cathepsin B and
cathepsin S are also increased in expression in OA tissue
Table 3
Fold change and threshold cycle ... metalloproteinase domain; ADAMTS: a disintegrin and metalloproteinase domain with thrombospondin motifs; Ct: threshold
cycle; IGF: insulin-like growth factor; IL: interleukin; MMP...
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