Báo cáo y học: "Altered expression of T cell Immunoglobulin-Mucin (TIM) molecules in bronchoalveolar lavage CD4+ T cells in sarcoidosis" docx

... present study indicates that HTLV-I infection could modify the inflammatory activity of ordinary primary OA, whereby direct activation by Tax protein might account for the increased concentrations ... possible that the altered inflammatory activity is partial and transient during the nat- ural course of OA and does not continue to the final stage. In contrast to the development of sys...

Ngày tải lên: 09/08/2014, 01:23

... suggesting that TIM-1 controls critical regulatory pathways in the immune system. Studies on mice have indicated that TIM- 1 is involved in T helper cell differentiation and suggested that the protein ... represent a T cell defect to control the Th1 response, which might contrib- ute to the accumulation of inflammatory cells in the lungs and the pathogenesis of sarcoidosis...

Ngày tải lên: 12/08/2014, 14:20

... circa- dian rhythms in the rats, with peak activity occurring at night. Our results showed that the expression of mPER1 in the kidneys was higher at night in the control mice, coin- ciding with the peak ... neuropeptide pituitary adenylyl cyclase activating peptide (PACAP) as the principal neurotransmitters for light entrainment [21]. In order to optimize the bodily function of...

Ngày tải lên: 10/08/2014, 09:20

... stability test. The validity of this system is further demonstrated through the observation of 2 rats in constant dark conditions that displayed the expected free running of their circadian rhythm. Conclusion: ... minute) in front of the system during 10 hours. Since the metronome signal is stable in time, we tested the detection stability of our system. We also applied a shor...

Ngày tải lên: 10/08/2014, 09:20

... role in the regula- tion of apoptosis. In this study we systematically investigated the expression and interplay of the Fas/FasL system in fibroblasts obtained from patients with and without lung ... process that is highly selective in eliminating aged and injured cells. In addition to inter- nal pathways that mainly trigger apoptosis in response to cytotoxic stress, apopto...

Ngày tải lên: 12/08/2014, 18:21

... SLE patients and healthy control individuals, although interpreta- tion of this finding is limited by the inability of the anti-CD32 antibody to distinguish the activating FcγRIIa and inhibitory FcγRIIb. ... facilitate the infiltration of these cells to the sites of IC deposition in the kidney [48]. Since IFNα and IFNγ also stimulate the production of monocyte attractants such a...

Ngày tải lên: 09/08/2014, 01:22

... monocytes between the SLE patients and healthy control individuals, although interpreta- tion of this finding is limited by the inability of the anti-CD32 antibody to distinguish the activating ... participated in statistical analysis. MS assisted in data interpretation. MSS participated in acquisition of data and patient recruitment. WHR carried out the study design and data inte...

Ngày tải lên: 09/08/2014, 13:22

... CTCCA- CAATTAAAACTG-3’ (sense) and 5’-GTCCATGGCTG- TAATTCAACACAACTGTTTAATAGTAC-3’ (anti- sense). Primers permitting the addition of a Flag tag at the COOH end of the ASP ORF, 5’ -CATGGGACTACA Clerc et ... Propensity for HBZ-SP1 isoform of HTLV-I to inhibit c-Jun activity correlates with sequestration of c-Jun into nuclear bodies rather than inhibition of its DNA-binding activity. Vi...

Ngày tải lên: 13/08/2014, 01:21

... example, the transforming activity of Tax1 is abrogated by muta- tions that impair the ability of Tax1 to activate NF-κB [24- 26]. Tax1 inhibits apoptosis of mouse T- cell lines by induction of the anti-apoptotic ... constitutively active as seen in HTLV-1 transformed cells [33]. It appears that this consti- tutive NF-κB activation contributes to the survival and chemotherapy r...

Ngày tải lên: 13/08/2014, 09:21

... distilled water. Finally, sections were counterstained in hematoxylin for 30 s and mounted in AQUATEX Ò (Merck, Darmstadt, Germany). Statistical analyses The paired Student’s t- test (two-tailed) ... event in viable cells that marks a process rela- ted with the cell cycle status [45]. In this context, it is important to stress that DNA content studies did not show significant diff...

Ngày tải lên: 19/02/2014, 16:20