Báo cáo y học: "A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice" pps
Báo cáo y học: "A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice" pps
... adenylate cyclase and hydrolysis by phosphodiesterases (PDE). The PDEs represent a large family of isozymes [18], of which PDE4B and PDE4D isotypes are predominantly expressed in a variety of inflammatory and ... a combination of AONs against PDE4 and PDE7 subtypes would mediate improved pharmaco- logical activity as compared to PDE4 only inhibitors. This study therefore exa...
Ngày tải lên: 12/08/2014, 14:20
Báo cáo y học: " Intermittent long-wavelength red light increases the period of daily locomotor activity in mice" ppsx
... locomotor activity Activity events were grouped into 5-minute bins by the Stanford Chronobiology Systems' (Stanford, CA) data processing and automatic storage system integrated into a Dell computer. ... drop sharply and is vanishingly small at wavelengths above 600 nm (orange light) [7-9]. In mice lacking rods and cones, the peak sensitivity for phase-shifting is 481 nm, and se...
Ngày tải lên: 10/08/2014, 09:20
Báo cáo y học: "Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis" pps
... between SP-D and the Met11Thr polymorphism in early, untreated RA, and by studying the correlation between SP-D and disease activity measures and radiographic progression during a four-year interventional ... four years indicate, that subnormal SP-D is primar- ily linked t o systemic inflammation. According to this, depressed systemic SP-D may contribute to persistent low-grade, su...
Ngày tải lên: 12/08/2014, 12:20
Báo cáo y học: "A blind deconvolution approach to high-resolution mapping of transcription factor binding sites from ChIP-seq data" pps
... 100 bp or less), instead interpreting such cases as a single, incorrectly located binding site. Such cases of closely spaced binding sites arise regularly, especially in prokaryotic genomes (see, ... identify binding sites by searching for enrichment peaks in sequenced reads, we recognize that peaks cannot be clearly and distinctly resolved when binding sites are separated by short dist...
Ngày tải lên: 09/08/2014, 20:21
Báo cáo y học: "An alternative surgical approach to subclavian and innominate stenosis: a case series" ppsx
... carotid-subclavian bypass and axillo-axillary bypass. Using the ascending aorta eliminates this risk. Patients who have or will ha ve coronary revascularisa- tion using an internal mammary artery as a conduit ... problem in subclavian and innominate stenosis, as functionally the vascular segment between the origin of subclavian artery and the coronary artery becomes part of coronary c...
Ngày tải lên: 10/08/2014, 09:22
Báo cáo y học: "A social marketing approach to implementing evidence-based practice in VHA QUERI: the TIDES depression collaborative care model" docx
... sites, was incorporated into a national funding initiative for primary care mental health in 2006, and incorporated into national policy in 2008. Therefore, TIDES can be described as being in Phase ... underlying mar- keting theory and associated evaluation activities. Social marketing: Applying marketing techniques to social problems Marketing is "the process of planning and...
Ngày tải lên: 11/08/2014, 05:21
Báo cáo y học: "A targeted lipidomics approach to the study of eicosanoid release in synovial joints" pdf
... PR, Barneveld A: Influence of repeated arthrocentesis and exercise on synovial fluid concentrations of nitric oxide, prostaglandin E 2 and glycosaminoglycans in healthy equine joints. Equine Vet J 2005, 37:250-256. 20. ... (Figures 5 and 6). As LPS induces marked influx of leukocytes (predominantly neutrophils [9]) into the j oint space, eicosanoid species detected may partly reflect...
Ngày tải lên: 12/08/2014, 17:22
Báo cáo y học: " A validity-driven approach to the understanding of the personal and societal burden of low back pain: development of a conceptual and measurement model" doc
... lazy by others Self worth degraded by how you feel others see you • Always trying to hide pain from family so they don’t worry • Feel like a burden on workmates Negative/discriminatory ... supported by available evidence at any point in time. An important initial step in scale development, and the final step in development of the hypothesized model, involves writing (hypo...
Ngày tải lên: 12/08/2014, 18:20
Báo cáo y học: " A new computational approach to analyze human protein complexes and predict novel protein interactions" pdf
... Thy-Noc, thymidine-nocodazole synchro- nized cell dataset; Thy-Thy2, thymidine-thymidine synchronized cell dataset 2; Thy-Thy3, thymidine-thymidine synchronized cell dataset 3; TU, transducing ... the same analysis on the Pearson's case described above by using a hypergeometric test. Among the 32 protein complexes analyzed, 14 in Thy-Thy2, 13 in Thy- Thy3 and 13 in Thy-Noc showed...
Ngày tải lên: 14/08/2014, 08:20
Báo cáo y học: "A non-parametric approach for identifying differentially expressed genes in factorial microarray experiments" potx
... using the parametric linear regression approach by assuming (1) normality in the log intensity of gene expressions and (2) linear relationship between log intensity and the effects of main ... in the experiment is represented firstly by genes differentially expressed in the two cell lines, and secondly by genes regulated in response to vitamin D treatment in the hMSC-dlk...
Ngày tải lên: 14/08/2014, 14:21