Báo cáo y học: " Sildenafil attenuates pulmonary inflammation and fibrin deposition, mortality and right ventricular hypertrophy in neonatal hyperoxic lung injury" pps

... purposes) Respiratory Research Open Access Research Sildenafil attenuates pulmonary inflammation and fibrin deposition, mortality and right ventricular hypertrophy in neonatal hyperoxic lung injury Yvonne ... PS, Wagenaar GT: Inhaled nitric oxide attenuates pulmonary inflammation and fibrin deposition and prolongs survival in neonatal hyperoxic...

Ngày tải lên: 12/08/2014, 14:20

... role in basal and TNFα-mediated pulmonary inflammation and pulmonary epithelial barrier dysfunction via its regulation of other inflammatory cytokines such as IL-8, which could in part explain ... TNFα/soluble TNF-receptor in the BALF and severity of ALI (lung com- pliance and severity of hypoxemia) [13]. The role of TNFα in pulmonary pathophysiology has been well stu...

Ngày tải lên: 11/08/2014, 08:22

... to the SOFA scoring sys- tem in predicting ICU mortality and could predict inhospital mortality at 3 months. Competing interests The authors declare that they have no competing interests. Authors' ... patients remains problematic, resulting in increased interest in potential circulating markers, such as cytokines, procalcitonin and brain natriuretic peptide. Recent reports...

Ngày tải lên: 12/08/2014, 23:23

... recruited PIMs in endotoxin-induced mortality in a BDL rats. It is striking that depletion of a single inflammatory cell results in remarkable reduction in key inflammatory cytokines, inhibition of lung inflammation ... LPS-induced mortality in BDL rats We delineated role of PIMs by comparing LPS-induced lung inflammation and mortality in BDL rats and GC- treate...

Ngày tải lên: 12/08/2014, 14:20

... purposes) Rapamycin reverses hypoxia-induced thickening of the right ventricular wall and hypertrophy of individual cardiomyocytesFigure 6 Rapamycin reverses hypoxia-induced thickening of the right ventricular ... purposes) Rapamycin attenuates hypoxia-triggered thickening of the right ventricular wall and hypertrophy of individual cardiomyocytesFigure 4 Rapamycin atten...

Ngày tải lên: 12/08/2014, 15:20

... (CRP) is increased in obesity and associated with insulin resistance [53]. Furthermore, adi- ponectin levels are reduced in obesity and associated with insulin resistance and hyper insulinaemia ... IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 1996, 271:665-668. 51. Porter MH, Cutchins A, Fine...

Ngày tải lên: 12/08/2014, 16:20

... by altered energy and protein metabolism (reduced total energy expenditure, increased rest- ing energy expenditure, and increased whole-body protein catabolism) and increased inflammatory cytokine ... synovial hyperplasia and inflammatory cell invasion in joint tissues. Interestingly, TM can inhibit the expression of vascular endothelial growth factor in serum synovial tissues, es...

Ngày tải lên: 09/08/2014, 07:20

... quantification of inflamma- tory spinal changes, the AS-spinal-MRI scoring system [13] has shown good discriminatory capacity, validity, and sensitiv- ity to change in MRI examinations for periods ... (13.3%) showing inflammation. Development of syn- desmophytes was found in 2/41 VEs (4.9%) and in 2/31 VEs (6.5%) that showed inflammatory lesions at 2yFU. In contrast, syndesmophyt...

Ngày tải lên: 09/08/2014, 13:21

... cells) and bNOS (found in brain and neuronal tissue) are constitutive and important in blood pressure regulation and memory; iNOS is an isoform that can be induced by pro-inflammatory cytokines and ... a hematoma and platelet activation. Erythrocytes and inflamma- tory cells, particularly neutrophils, enter the site of injury. In the first 24 hours, monocytes and macroph...

Ngày tải lên: 09/08/2014, 14:21

... includ- ing fibrosis and inflammation. The cardiac coronary artery and liver paraffin section were stained with Hematoxylin & Eosin. Immunohistochemistry and immunofluorescent analysis Mice were ... attenuated in the I+G+St mice (Table 2). Flow cytometry analysis of CD11b and Ly6G proteins (myeloid cells surface markers expressed mainly on the monocytes, macrophages and granu...

Ngày tải lên: 10/08/2014, 05:21