Báo cáo y học: " Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells" doc

... purposes) Respiratory Research Open Access Research Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells Yaqin Xu †1 , Christine ... 2). Especially, inflammation related genes were up-regulated upon the P. aeruginosa infection in both WT and CF mice, including 27 interferon...

Ngày tải lên: 12/08/2014, 14:20

... authors reported that CFTR contained the insect glycosylation phe- notype and was not fully glycosylated. As the authors pointed out, the glycosylation phenotype is influenced by the host’s enzymes; however, ... wild-type. Available online http://respiratory-research.com/content/2/5/276 Introduction Interest in glycosylation has been rekindled in the field of CF research since...

Ngày tải lên: 12/08/2014, 18:20

... severe pulmonary damage (reviewed in [3,7,17]). Along with the inappropriate influx of neutrophil into the CF airways, a dysregulation in the levels of inflammatory cytokines, including IL-1β, ... disease caused by mutations in the Cystic Fibrosis Transmem- brane conductance Regulator (CFTR) gene [1,2]. Clinical manifestations of CF include exocrine pancreatic insu...

Ngày tải lên: 12/08/2014, 16:20

... the following day. At one-year follow-up with the Cystic Fibrosis C linic and the Neurosurgery Service, our pa tient was continuin g to do well with no signs or symptoms of increased intra- cranial ... scoliosis in cystic fibrosis. Pediatr Pulmonol 1995, 19:317-318. 7. Mulberg AE, Weyler RT, Altschuler SM, Hyde TM: Cystic fibrosis transmembrane conductance regulator...

Ngày tải lên: 10/08/2014, 23:22

... [6,30]. Accordingly, the NBD1 proteins employed in this study (Thr389–Gly673) contain many of these short, hydrophobic sequences, including the region around Phe508, constituting potential Hsc70-binding ... F508del-mNBD1. Assessment of the impact of F508del on the NBD1–Hsc70 interaction To determine the strength of the NBD1–Hsc70 inter- action, we thus immobilized the...

Ngày tải lên: 23/03/2014, 05:22

... resulting in the recruitment of activated immune and inflammatory cells to the site of inflammatory lesion, thereby amplify- ing and sustaining the inflammatory condition [8]. The pro-inflammatory ... via modulation of the activation and DNA binding activity of NF-κB. Discussion Mast cells are emerging key players in the erosive and inflammatory events leading to joint...

Ngày tải lên: 11/08/2014, 08:22

... described by Beck. Furthermore, the second principal component, while including elements akin to canonically described hopelessness, is distinct no tonlybyvirtueofexisting within the context of this syndrome, ... and contributed the design and completion of the data analyses. CK assisted in the drafting of the manuscript, performance of the statistical analyses, as wel...

Ngày tải lên: 11/08/2014, 16:22

... an increase of the expression of NR1 and NR2B subunits of the NMDA receptor within the spinal cord from p14 rats of the morphine group (Figure 2A; 2C). When the quantities of the expression of ... more severe inflammatory hyperalgesia in the offspring rats (p18), which could be prevented by the co-administration of DM in the dams Before carrageenan inje...

Ngày tải lên: 10/08/2014, 10:20

... Gyi 1 Addresses: 1 Department of Cystic Fibrosis, Royal Brompton Hospital and NHLI/Imperial College, Sydney Street, London, SW3 6NP, UK 2 Department of Cystic Fibrosis, King’s College Hospital, Denmark Hill, London, SE5 ... distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction: Cystic fibrosis is usually associated...

Ngày tải lên: 11/08/2014, 14:20

... fusion proteins in the presence of Vif. To gain additional functional insights into the molecular mechanism underlying the ability of UBA2 to prevent protein degradation, the effects of UBA2 on ... pcDNA3.1(-)-Apo-U/ Hygromycin (U) for the APOBEC3G-UBA2 fusion, and pcDNA3.1(-)-Apo-M/Hygromycin (M) for the APOBEC3G-UBA2* mutant fusion. Protein stability of APOBEC3G was...

Ngày tải lên: 13/08/2014, 05:21